Zusammenfassung
Zytogenetische Diskrepanzen zwischen trophoblastären und embryonalen Gewe ben wurden erstmals von Ford (1969) bei der Maus beschrieben. Seitdem die Chorionbiopsie (Kazy et al. 1982) als alternatives Verfahren zur Amniozentese für die zytogenetische, biochemische und molekularbiologische Pränataldiagnostik etabliert ist, wurden solche Diskrepanzen auch beim Menschen bekannt. Bei den etwa 80 000 Chorionbiopsien, die inzwischen weltweit dokumentiert sind (Jackson 1991), wurden sowohl falsch-positive Befunde, d.h. aberranter Karyotyp im Choriongewebe mit Normalbefund beim Feten, als auch falsch-negative Befunde, d. h. Normalbefund im Chorion, aber aberranter Karyotyp beim Feten, beschrieben.
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Lattermann, U. (1995). Klinische Bedeutung zytogenetischer Diskrepanzen zwischen Plazenta und Fetus. In: Hillemanns, H.G. (eds) Geburtshilfe — Geburtsmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48048-5_16
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