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Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development pp 175–204Cite as

Role of the Trithorax (MLL): HOX Axis in HSC Development, Function, and Leukemia

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Part of the book series: Epigenetics and Human Health ((EHH))

Abstract

The discovery of mixed lineage leukemia (MLL) fusions as causal event for a very aggressive subtype of acute leukemia has spurred a large body of research investigating the importance of this protein and its fusion derivatives for normal and malignant hematopoiesis. Here, recent advances examining the chromatin-based functions of the histone methyltransferase MLL as epigenetic factor and cell cycle regulator are summarized. This is complemented by a review of the current knowledge describing the oncogenic mechanism of MLL fusion proteins that coordinately impact chromatin modification and transcriptional control. Finally, to complete the synopsis of MLL governed processes in blood cell development, this chapter ends with a short overview of the role of HOX-homeobox proteins as major MLL downstream effectors in the hematopoietic system.

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  1. Department of Genetics, Friedrich Alexander Universitaet Erlangen, Erwin-Rommel Street 3, 91058, Erlangen, Germany

    Robert K. Slany

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  1. Robert K. Slany
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Correspondence to Robert K. Slany .

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  1. Institute of Biomedical Research, University of Birmingham Medical and Dental Sciences, Birmingham, United Kingdom

    Constanze Bonifer

  2. Institute of Biomedical Research, University of Birmingham Medical and Dental Sciences, Birmingham, United Kingdom

    Peter N. Cockerill

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Slany, R.K. (2014). Role of the Trithorax (MLL): HOX Axis in HSC Development, Function, and Leukemia. In: Bonifer, C., Cockerill, P. (eds) Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development. Epigenetics and Human Health. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45198-0_7

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