Abstract
This chapter covers the basic principles of treatment of CRS, which were applied earlier for treating persons with CRS, and the prospects for the pathogenetic therapy of CRS. Although cases of CRS were registered more than 50 years ago, an analysis of the efficacy of the treatment is of considerable interest not only from a historical viewpoint. It is important to note that both the principles of treatment of persons with CRS and the symptomatic therapy still remain relevant.
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Notes
- 1.
Thesan formerly was used as a stimulant of leukopoiesis. Antianemin – aqueous extract of bovine liver which was used for the treatment of anemia (Mashkovsky 1958).
- 2.
Lipocerebrin – a preparation of the brain of bovine cattle containing brain phospholipids.
- 3.
Phosphren – medicine containing organic phosphorus, lecithin, iron, and calcium salts.
- 4.
Phytin – a complex organic preparation of phosphorous, which was used for the treatment of various diseases.
References
Akleyev AV, Silkina LA, Kozheurov VP, Fomin VA (1995) The effect of the food additive Medetopekt on the health status of individuals chronically exposed to radiation. Ecol Issues South Urals 1:13–20 [Ekologicheskiye Problemy na Yuzhnom Urale, 1, 13–20 (Russian)]
Akleyev AV, Gritsenko VP, Marchenko TA (2008) Socio-psychological consequences of the accidental radiation exposure of the population in the Southern Urals. RADEKON, Moscow (Russian)
Alexeyeva OG, Vyalova NA, Grebneva AA et al (1963) Dynamic observation of health status in individuals exposed to uranium fission products. Radiat Med Bull 1а:47–52 [Bull Radiat Med 1а, 47–52 (Russian)]
Andrushchenko VN, Ivanov AA, Maltsev VN (1996) Radioprotective effect of substances of microbial origin. Radiatsionnaya Biologiya Radioecologiya 36:195–208 (Russian)
Baysogolov GD (1961) Clinical picture of chronic radiation disease at different stages of treatment. Institut Biofiziki, Moscow, p 336 (Russian)
Beyzadeoglu M, Balkan M, Demiriz M et al (1997) Protective effect of vitamin A on acute radiation injury in the small intestine. Radiat Med 15:1–5 (Russian)
Blomstrand C, Johansson B, Rosengren B (1975) Dexamethasone effect on blood-brain barrier damage caused by acute hypertension in x-irradiated rabbits. Acta Neurol Scand 52:331–334
Bolotin E, Smogorzewska M, Smith S et al (1996) Enhancement of thymopoiesis after BM transplant by in vivo interleukin-7. Blood 88:1887–1894
Bonsack ME, Felemovicius I, Baptista ML et al (1999) Radioprotection of the intestinal mucosa of rats by probucol. Radiat Res 151:69–73
Brown JM, Attardi LD (2005) The role of apoptosis in cancer development and treatment response. Nat Rev Cancer 5:231–237
Burdelya LG, Krivokrysenko VI, Tallant TC et al (2008) An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models. Science 320:226–230
Chamberlain G, Fox J, Ashton B et al (2007) Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 25:2739–2749
Chertkov KS (2004) Remedies used at early stages of treatment of acute radiation disease. Radiat Med 4:728–739 (Russian)
Delattre JY, Rosenblum MK, Thaler HT et al (1988) A model of radiation myelopathy in the rat. Pathology, regional capillary permeability changes and treatment with dexamethasone. Brain 111(6):1319–1336
Doshchenko VN (1960) On the issue of the secretory, motor and hemopoietic function of the stomach in patients with chronic radiation disease. Bull Radiat Med 1a:57–85 (Russian)
Duan HF, Wu CT, Wu DL et al (2003) Treatment of myocardial ischemia with BM-derived mesenchymal stem cells overexpressing hepatocyte growth factor. Mol Ther 8:467–474
Fliedner TM, Graessle D, Paulsen C et al (2002) Structure and function of BM hemopoiesis: mechanisms of response to ionizing radiation exposure. Cancer Biother Radiopharm 17:405–426
Fry TJ, Sinha M, Milliron M et al (2004) Flt3 ligand enhances thymic-dependent and thymic-independent immune reconstitution. Blood 104:2794–2800
Geraci JP, Mariano MS, Jackson KL (1993) Amelioration of radiation nephropathy in rats by dexamethasone treatment after irradiation. Radiat Res 134:86–93
Giambarresi LI, Walker RI (1989) Prospects for radioprotection. Medical consequences of nuclear warfare 1:245–273
Glazunov IS, Blagoveshchenskaya VV, Vergilesova OS et al (1959) On the issue of functional impairment of the nervous system in radiation disease. Bull Radiat Med 1a:3–15 (Russian)
Gray DH, Seach N, Ueno T et al (2006) Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood 108:3777–3785
Guskova AK, Baysogolov GD (1971) Radiation disease in man. Meditsina, Moscow (Russian)
Hall JE, Martin KA, Whitney HA et al (1994) Potential for fertility with replacement of hypothalamic gonadotropin-releasing hormone in long term female survivors of cranial tumors. J Clin Endocrinol Metab 79:1166–1172
Hauer-Jensen M, Fink LM, Wang J (2004) Radiation injury and the protein C pathway. Crit Care Med 32:325–330
Hopewell JW, Van den Aardweg GJ, Morris GM et al (1994) Unsaturated lipids as modulators of radiation damage in normal tissues. In: Horrobin DF (ed) New approaches to cancer treatment. Churchill Communications, Europe, London, pp 99–106
Hornsey S, Myers R, Jenkinson T (1990) The reduction of radiation damage to the spinal cord by post-irradiation administration of vasoactive drugs. Int J Radiat Oncol Biol Phys 18:1437–1442
ICRP (2012) Early and late effects of radiation in normal tissues and organs: threshold doses for tissue reactions in a radiation protection context. Ann ICRP 41(1–2):304, ICRP Publication 118, Elsevier Ltd
Ina Y, Tanooka H, Yamada T et al (2005) Suppression of thymic lymphoma induction by life-long low-dose-rate irradiation accompanied by immune activation in C57BL/6 mice. Radiat Res 163:153–158
Ivanov VA (1968) The results medical follow-up of persons resident in raions contaminated with fission products. Doctoral thesis, Institut Biofiziki, Moscow, p 544 (Russian)
Ivanov VA (1971) The results of medical follow-up of persons resident in localities contaminated with uranium fission products. Bull Radiat Med 2:12–20 (Russian)
Jackson KA, Majka SM, Wang H et al (2001) Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest 107:1395–1402
Kaushansky K (2006) Lineage-specific hematopoietic growth factors. N Engl J Med 354:2034–2045
Kenins L, Gill JW, Boyd RL et al (2008) Intrathymic expression of Flt3 ligand enhances thymic recovery after irradiation. J Exp Med 205:523–531
Knox SJ, Fowler S, Marquez C et al (1994) Effect of filgrastim (G-CSF) in Hodgkin's disease patients treated with radiation therapy. Int J Radiat Oncol Biol Phys 28:445–450
Kojima S, Ishida H, Takahashi M et al (2002) Elevation of glutathione induced by low-dose gamma rays and its involvement in increased natural killer activity. Radiat Res 157:275–280
Kumar KS, Srinivasan V, Toles R et al (2002) Nutritional approaches to radioprotection: Vitamin E. Mil Med 167:57–59
Kurshakov NA (1956) Chronic radiation sickness. Bull Radiat Med 4:3–20 (Russian)
Liu H, Xiong M, Xia YF et al (2009) Studies on pentoxifylline and tocopherol combination for radiation-induced heart disease in rats. Int J Radiat Oncol Biol Phys 73:1552–1559
MacVittie TJ, Farese AM, Jackson W 3rd (2005) Defining the full therapeutic potential of recombinant growth factors in the post radiation-accident environment: the effect of supportive care plus administration of G-CSF. Health Phys 89:546–555
Mashkovsky MD (1958) Medicinal agents (Reference book for physicians). Moscow, Medgiz p 811
Matsubara J, Turcanu V, Poindron P et al (2000) Immune effects of low-dose radiation: short-term induction of thymocyte apoptosis and long-term augmentation of T-cell-dependent immune responses. Radiat Res 153:332–338
Meyn RE, Milas L, Ang KK (2009) The role of apoptosis in radiation oncology. Int J Radiat Biol 85:107–115
Monobe M, Hino M, Sumi M et al (2005) Protective effects of melatonin on gamma-ray induced intestinal damage. Int J Radiat Biol 81:855–860
Moulder JE, Robbins ME, Cohen EP et al (1998) Pharmacologic modification of radiation-induced late normal tissue injury. Cancer Treat Res 93:129–151
Moulder JE, Fish BL, Cohen EP (2007) Treatment of radiation nephropathy with ACE inhibitors and AII type–1 and type-2 receptor antagonists. Curr Pharm Des 13:1317–1325
Mozdarani H, Ghoraeian P (2008) Modulation of gamma-ray-induced apoptosis in human peripheral blood leukocytes by famotidine and vitamin C. Mutat Res 649:71–78
Okladnikova ND, Sumina MV et al (1992) Chronic radiation disease induced by external gamma-radiation in man, late period. Bull RAMSci 2:22–28 (Russian)
Okladnikova ND, Pesternikova VS, Sumina MV, Doshchenko VN (1993) Radiation-related occupational diseases at the first atomic industry plant. Med Radiol 12:24–28 (Russian)
Oliper TV (1960) Ostealgic syndrome in the clinic of chronic radiation disease. Bull Radiat Med 1a:73–80 (Russian)
Orlic D, Kajstura J, Chimenti S et al (2001) Mobilized BM cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci U S A 98:10344–10349
Patchen ML, MacVittie TJ, Jackson WE (1989) Postirradiation glucan administration enhances the radioprotective effects of WR–2721. Radiat Res 117:59–69
Prasad KN (2005) Rationale for using multiple antioxidants in protecting humans against low doses of ionizing radiation. Br J Radiol 78:485–492
Ramanan S, Kooshki M, Zhao W et al (2008) PPARalpha ligands inhibit radiation-induced microglial inflammatory responses by negatively regulating NF-kappaB and AP-1 pathways. Free Radic Biol Med 45:1695–1704
Rezvani M, Birds DA, Hodges H et al (2001) Modification of radiation myelopathy by the transplantation of neural stem cells in the rat. Radiat Res 156:408–412
Robbins ME, Payne V, Tommasi E et al (2009) The AT1 receptor antagonist, L-158,809, prevents or ameliorates fractionated whole-brain irradiation-induced cognitive impairment. Int J Radiat Oncol Biol Phys 73:499–505
Rossi SW, Jeker LT, Ueno T et al (2007) Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells. Blood 109:3803–3811
Shirazi A, Ghobadi G, Ghazi-Khansari M (2007) A radiobiological review on melatonin: a novel radioprotector. J Radiat Res (Tokyo) 48:263–272
Shoigu SK (ed) (2002) Consequences of the anthropogenic radiation exposure and issue of rehabilitation of the Urals region. Infolio-Print, Moscow (Russian)
Soule BP, Hyodo F, Matsumoto K et al (2007) The chemistry and biology of nitroxide compounds. Free Radic Biol Med 42:1632–1650
Springer IN, Niehoff P, Acil Y et al (2008) BMP-2 and bFGF in an irradiated bone model. J Craniomaxillofac Surg 36:210–217
Tada E, Matsumoto K, Kinoshita K et al (1997) The protective effect of dexamethasone against radiation damage induced by interstitial irradiation in normal monkey brain. Neurosurgery 41:209–217
UNSCEAR (2009) Effects of ionizing radiation on the immune system. United Nations Scientific Committee on the Effects of Atomic Radiation 2006 Report to the General Assembly, with scientific annexes. UN Publication Sales No. E.09.IX.5. United Nations, New York, USA
Ward WF, Kim YT, Molteni A et al (1988) Radiation-induced pulmonary endothelial dysfunction in rats: modification by an inhibitor of angiotensin converting enzyme. Int J Radiat Oncol Biol Phys 15:135–140
Ward WF, Molteni A, Ts'ao CH et al (1992) Radiation pneumotoxicity in rats: modification by inhibitors of angiotensin converting enzyme. Int J Radiat Oncol Biol Phys 22:623–625
Waselenko JK, MacVittie TJ, Blakely WF et al (2004) Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group. Ann Intern Med 140:1037–1051
Wouters KA, Kremer LC, Miller TL et al (2005) Protecting against anthracycline-induced myocardial damage: a review of the most promising strategies. Br J Haematol 131:561–578
Wynn TA (2008) Cellular and molecular mechanisms of fibrosis. J Pathol 214(2):199–210
Zhao W, Payne V, Tommasi E et al (2007) Administration of the peroxisomal proliferator-activated receptor gamma agonist pioglitazone during fractionated brain irradiation prevents radiation-induced cognitive impairment. Int J Radiat Oncol Biol Phys 67:6–9
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Akleyev, A.V. (2014). Treatment of Persons with CRS. In: Chronic Radiation Syndrome. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45117-1_8
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