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Dynamics of Hematopoietic Changes in Persons with CRS

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Chronic Radiation Syndrome

Abstract

This section more thoroughly elaborates the dynamics of changes in the hematopoietic system which was critical in residents of the Techa riverside villages both as a result of the highest exposure doses due to 90Sr and also because of the high radiosensitivity of HSC (HSC). It is known that hematopoietic system maintains constant cell number in the peripheral blood and immune homeostasis. The major clinical changes in the period of CRS formation were cytopenia (neutropenia, thrombocytopenia, and less frequently lymphopenia), and changes in the RBM (delays in the maturation of the granulocytes at the stage of myelocyte, accelerated maturation and increased proliferation of erythrokaryocytes, etc.). A high level of lethal aberrations (chromosomal bridges, fragmentosis of the nucleus, etc.) and abnormal mitoses (chromosome clumping) were registered in the RBM cells. The dynamics of hematological disorders is determined by the dose rate to RBM. The extent and duration of the hematopoiesis recovery depend on the degree of CRS severity. In mild CRS cases there may occur a gradual spontaneous recovery of the hematopoiesis. In the majority of such patients in six to ten years after the onset of the exposure the number of neutrophils, thrombocytes and lymphocytes normalized .

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Authors and Affiliations

  1. Clinical Department, Urals Research Centre for Radiation Medicine, Chelyabinsk, Russia

    Alexander V. Akleyev MD, PhD

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  1. Alexander V. Akleyev MD, PhD
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Akleyev, A.V. (2014). Dynamics of Hematopoietic Changes in Persons with CRS. In: Chronic Radiation Syndrome. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45117-1_6

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  • DOI: https://doi.org/10.1007/978-3-642-45117-1_6

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-45116-4

  • Online ISBN: 978-3-642-45117-1

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