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Mechanisms Involved in Chronic Radiation Exposure Effects: Pathogenesis of Chronic Radiation Syndrome

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Chronic Radiation Syndrome

Abstract

Chronic radiation syndrome is considered to be a system response of a human body as a unified whole to chronic radiation exposure. Human body is not a simple set of organs, and its response to total body exposure is not a sum of responses manifested by individual organs. Organs are functionally interconnected due to, first of all, the regulatory systems (nervous, endocrine, and immuno-hematopoietic), and this maintains the homeostasis. At the initial stage, CRS is a typical “disadaptive” pathology characterized by non-specific functional disorders of hematopoiesis, nervous system and internal organs. At the basis of such changes there are radiation-induced impairments in the regulatory systems. Visceral disturbances are secondary in nature, and they are reversible. If the exposure dose for certain organs exceeds the threshold values, then, not only functional, but also organic changes develop (vascular impairments, dystrophy, fibrosis, RBM hypoplasia, etc.), and the CRS course acquires an irreversible character.

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  1. Clinical Department, Urals Research Centre for Radiation Medicine, Chelyabinsk, Russia

    Alexander V. Akleyev MD, PhD

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Akleyev, A.V. (2014). Mechanisms Involved in Chronic Radiation Exposure Effects: Pathogenesis of Chronic Radiation Syndrome. In: Chronic Radiation Syndrome. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-45117-1_3

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