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The β-Lactam Antibiotics: Their Future in the Face of Resistance

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Abstract

The search for new β-lactam antibacterial agents is a major challenge in medicinal and pharmaceutical chemistry. Methicillin-resistant Staphylococcus aureus (MRSA), pan-resistant Enterobacteriaceae, and pan-resistant nonfermenter bacteria are present day clinical scourges. New cephalosporins and carbapenems may solve this problem, but new monosulfactams and monocarbams also show promise. High-molecular-mass PBPs are envisioned as β-lactam targets. Further research keeps revealing interesting aspects about β-lactam resistance by β-lactamases, the existence of sentinel proteins, and the complexity of the cell envelope.

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  1. Department of Chemistry and Biochemistry, Nieuwland Science Hall, University of Notre Dame, Notre Dame, IN, 46556-5670, USA

    Erika Leemans, Jed F. Fisher & Shahriar Mobashery

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  1. Erika Leemans
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  2. Jed F. Fisher
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  3. Shahriar Mobashery
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Correspondence to Shahriar Mobashery .

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  1. Dipartimento di Biotecnologie e Scienze Molecolari, Università degli Studi dell'Insubria, Varese, Italy

    Flavia Marinelli

  2. Parque Tecnológico Ciencias de la Salud, Fundación MEDINA, Granada, Spain

    Olga Genilloud

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Leemans, E., Fisher, J.F., Mobashery, S. (2014). The β-Lactam Antibiotics: Their Future in the Face of Resistance. In: Marinelli, F., Genilloud, O. (eds) Antimicrobials. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39968-8_4

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