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Antimicrobials pp 29–56Cite as

Gram-Negative Pathogens: Overview of Novel and Emerging Resistant Pathogens and Drugs

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Abstract

The rising prevalence of multiresistant Gram-negative bacterial infections has become a major clinical problem, as currently such infections comprise the majority of untreatable bacterial infections. The variety of resistance and transfer mechanisms and their rapid spread among Gram-negative bacteria constitutes a global infection control challenge, and an urgent need for development of new antimicrobials. Unfortunately, infection rates with multiresistant nonfermenters, such as Pseudomonas aeruginosa, Acinetobacter baumannii, or extended-spectrum β-lactamase producing Enterobacteriaceae and carbapenem resistant Enterobacteriaceae such as Klebsiella pneumoniae, are growing progressively while the pace of antibiotic drug development has slowed considerably during the last decade. This chapter reviews the main emerging Gram-negative resistant pathogens, their various resistance mechanisms, prevalence, risk factors, and summarizes the novel drugs being developed against them.

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Authors and Affiliations

  1. Clinical Microbiology Laboratory, Meir Medical Center, Kfar Saba, Israel

    Yossi Paitan

  2. Department of Molecular Microbiology and Biotechnology, Tel Aviv University and MIGAL Galil Research Center, Kiriat Shmone, Israel

    Eliora Z. Ron

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  1. Yossi Paitan
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  2. Eliora Z. Ron
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Correspondence to Eliora Z. Ron .

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  1. Dipartimento di Biotecnologie e Scienze Molecolari, Università degli Studi dell'Insubria, Varese, Italy

    Flavia Marinelli

  2. Parque Tecnológico Ciencias de la Salud, Fundación MEDINA, Granada, Spain

    Olga Genilloud

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Paitan, Y., Ron, E.Z. (2014). Gram-Negative Pathogens: Overview of Novel and Emerging Resistant Pathogens and Drugs. In: Marinelli, F., Genilloud, O. (eds) Antimicrobials. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39968-8_3

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