Abstract
As a result of their anatomy and physiology, the organs and tissues of animals and man may show different morphological responses and sensitivity to xenobiotics. Toxic responses can manifest systemically (e.g., the immune system) or may produce specific toxic effects in a single organ system (skin) or single organ (liver). Organ toxicity may therefore result from a direct and primary effect on a target organ or as a result of secondary effects in organs and tissues that have a physiological dependence on the primary target (Haschek 2009). The assessment of organ toxicity must therefore take into account the complex physiological interdependence of tissues and organs within the body.
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Kaufmann, W., Jacobsen, M.C. (2020). Examination of Organ Toxicity. In: Reichl, FX., Schwenk, M. (eds) Regulatory Toxicology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-36206-4_32-2
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DOI: https://doi.org/10.1007/978-3-642-36206-4_32-2
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