Zusammenfassung
Das Kapitel behandelt die Besonderheiten der Mammakarzinome, die im Zusammenhang mit den häufigen und seltenen Keimbahnmutationen familiär gehäuft auftreten. Insbesondere wird auf die Brustkrebsgene BRCA1 und BRCA2 eingegangen.
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Agnarsson BA, Jonasson JG, Bjornsdottir IB et al (1998) Inherited BRCA2 mutation associated with high grade breast cancer. Breast Cancer Res Treat 47:121–127
Armes JE, Egan AJ, Southey MC et al (1998) The histologic phenotypes of breast carcinoma occurring before age 40 years in women with and without BRCA1 or BRCA2 germline mutations: a population-based study. Cancer 83:2335–2345
Arun B, Vogel KJ, Lopez A et al (2009) High prevalence of preinvasive lesions adjacent to BRCA1/2-associated breast cancers. Cancer Prev Res (Phila) 2:122–127
Atchley DP, Albarracin CT, Lopez A et al (2008) Clinical and pathologic characteristics of patients with BRCA-positive and BRCA-negative breast cancer. J Clin Oncol 26:4282–4288
Bässler R (1997) Pathologie prognostischer Kriterien. In: Remmele W (ed) Pathologie – Weibliches Genitale. Mamma, Pathologie der Schwangerschaft, der Plazenta und des Neugeborenen, Infektionskrankheiten des Fetus und des Neugeborenen, Tumoren des Kindesalters, Endokrine Organe. vol. 4. Springer, Berlin Heidelberg New York, pp 240–253
Bloom HJ, Richardson WW (1957) Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. Br J Cancer 11:359–377
Bordeleau L, Panchal S, Goodwin P (2010) Prognosis of BRCA-associated breast cancer: a summary of evidence. Breast Cancer Res Treat 119:13–24
Comen EA, Robson M (2010) Inhibition of poly(ADP)-ribose polymerase as a therapeutic strategy for breast cancer. Oncology (Williston Park) 24:55–62
Contesso G, Mouriesse H, Friedman S et al (1987) The importance of histologic grade in long-term prognosis of breast cancer: a study of 1,010 patients, uniformly treated at the Institut Gustave-Roussy. J Clin Oncol 5:1378–1386
Farges O, Fuks D, Le Treut YP et al (2011) AJCC 7th edition of TNM staging accurately discriminates outcomes of patients with resectable intrahepatic cholangiocarcinoma: By the AFC-IHCC-2009 study group. Cancer 117:2170–2177
Farshid G, Balleine RL, Cummings M et al (2006) Morphology of breast cancer as a means of triage of patients for BRCA1 genetic testing. Am J Surg Pathol 30:1357–1366
Gadzicki D, Schubert A, Fischer C et al (2009) Histopathological criteria and selection algorithms for BRCA1 genetic testing. Cancer Genet Cytogenet 189:105–111
Galea MH, Blamey RW, Elston CE et al (1992) The Nottingham Prognostic Index in primary breast cancer. Breast Cancer Res Treat 22:207–219
Gonzalez KD, Noltner KA, Buzin CH et al (2009) Beyond Li Fraumeni Syndrome: clinical characteristics of families with p53 germline mutations. J Clin Oncol 27:1250–1256
Gonzalez MA, Pinder SE (2011) Invasive carcinoma: other histologic, prognostic factors, prognostic indices, and application of prognostic information for patient management. In: O'Malley FP, Pinder SE, Mulligan AM (eds) Breast pathology. Elsevier, Philadelphia, pp 272–278
Gustafson S, Zbuk KM, Scacheri C et al (2007) Cowden syndrome. Semin Oncol 34:428–434
Habeck M (1999) New hepatitis virus discovered. Mol Med Today 5:462
Honrado E, Benitez J, Palacios J (2005) The molecular pathology of hereditary breast cancer: genetic testing and therapeutic implications. Mod Pathol 18:1305–1320
Honrado E, Osorio A, Palacios J et al (2006) Pathology and gene expression of hereditary breast tumors associated with BRCA1, BRCA2 and CHEK2 gene mutations. Oncogene 25:5837–5845
Kuhn W, Schmalfeldt B, Reuning U et al (1999) Prognostic significance of urokinase (uPA) and its inhibitor PAI-1 for survival in advanced ovarian carcinoma stage FIGO IIIc. Br J Cancer 79:1746–1751
Lakhani SR, Jacquemier J, Sloane JP et al (1998) Multifactorial analysis of differences between sporadic breast cancers and cancers involving BRCA1 and BRCA2 mutations. J Natl Cancer Inst 90:1138–1145
Le Doussal V, Tubiana-Hulin M, Friedman S et al (1989) Prognostic value of histologic grade nuclear components of Scarff-Bloom-Richardson (SBR). An improved score modification based on a multivariate analysis of 1262 invasive ductal breast carcinomas. Cancer 64:1914–1921
Marcus JN, Watson P, Page DL et al (1996) Hereditary breast cancer: pathobiology, prognosis, and BRCA1 and BRCA2 gene linkage. Cancer 77:697–709
Marcus JN, Watson P, Page DL et al (1997) BRCA2 hereditary breast cancer pathophenotype. Breast Cancer Res Treat 44:275–277
Narod SA (2010) BRCA mutations in the management of breast cancer: the state of the art. Nat Rev Clin Oncol 7:702–707
Nevanlinna H, Bartek J (2006) The CHEK2 gene and inherited breast cancer susceptibility. Oncogene 25:5912–5919
Osin PP, Lakhani SR (1999) The pathology of familial breast cancer: Immunohistochemistry and molecular analysis. Breast Cancer Res 1:36–40
Pinder SE, Ellis IO, Galea M et al (1994) Pathological prognostic factors in breast cancer. III. Vascular invasion: relationship with recurrence and survival in a large study with long-term follow-up. Histopathology 24:41–47
Prokopcova J, Kleibl Z, Banwell CM et al (2007) The role of ATM in breast cancer development. Breast Cancer Res Treat 104:121–128
Quenneville LA, Phillips KA, Ozcelik H et al (2002) HER-2/neu status and tumor morphology of invasive breast carcinomas in Ashkenazi women with known BRCA1 mutation status in the Ontario Familial Breast Cancer Registry. Cancer 95:2068–2075
Rakha EA, El-Sayed ME, Lee AH et al (2008) Prognostic significance of Nottingham histologic grade in invasive breast carcinoma. J Clin Oncol 26:3153–3158
Rakha EA, El-Sayed ME, Menon S et al (2008) Histologic grading is an independent prognostic factor in invasive lobular carcinoma of the breast. Breast Cancer Res Treat 111:121–127
Rebbeck TR, Lynch HT, Neuhausen SL et al (2002) Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations. N Engl J Med 346:1616–1622
Schrader KA, Masciari S, Boyd N et al (2008) Hereditary diffuse gastric cancer: association with lobular breast cancer. Fam Cancer 7:73–82
Schumacher M, Schmoor C, Sauerbrei W et al (1993) The prognostic effect of histological tumor grade in node-negative breast cancer patients. Breast Cancer Res Treat 25:235–245
Shore RE, Hempelmann LH, Kowaluk E et al (1977) Breast neoplasms in women treated with x-rays for acute postpartum mastitis. J Natl Cancer Inst 59:813–822
Turner N, Tutt A, Ashworth A (2004) Hallmarks of 'BRCAness' in sporadic cancers. Nat Rev Cancer 4:814–819
Turner NC, Reis-Filho JS (2006) Basal-like breast cancer and the BRCA1 phenotype. Oncogene 25:5846–5853
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Böcker, W. (2013). Mammakarzinome mit Keimbahnmutationen. In: Klöppel, G., Kreipe, H., Remmele, W., Dietel, M. (eds) Pathologie. Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04564-6_8
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