Abstract
The aim of this research was to develop a method to quantitate the changes in regional brain metabolism on serial FDG-PET scans in children with Traumatic Brain Injury (TBI) in order to determine their response to treatment with psycho stimulant medication. Methods: A Fusion-Based Image Subtraction (FBIS) technique was developed in order to calculate the differences in metabolism between baseline and follow-up scans. The FDG-PET brain images were count normalized to account for differences in the injected activity. Image registration was then performed using a 3D normalized mutual information algorithm and subsequently the fused images were subtracted on a pixel by pixel basis. FBIS extracted areas of increased or decreased metabolism were then compared to a database of normal subjects using NeuroQ (Syntermed, Inc.) and analyzed for statistical significance in cluster areas defined by a standard brain template. Results: Validation of the technique was performed using images from 15 pediatric cases with severe TBI who had baseline (pre-treatment) and follow-up (post-treatment) scans. The FBIS technique was found to be accurate in detecting and localizing the statistically significant changes in regional cerebral metabolism and provided useful data that could be applied clinically. Conclusions: The developed FBIS method identified and quantified areas of regional brain metabolic change thus providing a way to evaluate the effects of pharmacologic treatment in children with TBI. This quantitative technique could be used as an adjunct tool to enhance the interpretation of FDG-PET brain images and aid the referring clinician to assess the response to pharmacologic treatment.
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© 2009 Springer-Verlag Berlin Heidelberg
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Georgiou, M.F., Kuker, R.A., Kuluz, J., Sfakianakis, G.N. (2009). Quantitation of Metabolic Change in Serial FDG-PET Brain Scans of Pediatric Patients with Traumatic Brain Injury. In: McGoron, A.J., Li, CZ., Lin, WC. (eds) 25th Southern Biomedical Engineering Conference 2009, 15 – 17 May 2009, Miami, Florida, USA. IFMBE Proceedings, vol 24. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01697-4_22
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DOI: https://doi.org/10.1007/978-3-642-01697-4_22
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-01696-7
Online ISBN: 978-3-642-01697-4
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