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References
Ikoma A, Steinhoff M, Stander S, Yosipovitch G, Schmelz M (2006) The neurobiology of itch. Nat Rev Neurosci 7:535–547
Schmelz M, Schmidt R, Bickel A, Handwerker HO, Torebjork HE (1997) Specific C-receptors for itch in human skin. J Neurosci 17:8003–8008
Schmelz M, Schmidt R, Weidner C, Hilliges M, Torebjork HE, Handwerker HO (2003) Chemical response pattern of different classes of C-nociceptors to pruritogens and algo-gens. J Neurophysiol 89:2441–2448
Andrew D, Craig AD (2001) Spinothalamic lamina 1 neurons selectively sensitive to histamine: a central neural pathway for itch. Nat Neurosci 4:72–77
Shelley WB, Arthur RP (1955) Mucunain, the active prurito-genic proteinase of cowhage. Science 122:469–470
Ikoma A, Handwerker H, Miyachi Y, Schmelz M (2005) Electrically evoked itch in humans. Pain 113:148–154
Vogt BA (2005) Pain and emotion interactions in subregions of the cingulate gyrus. Nat Rev Neurosci 6:533–544
Brooks J, Tracey I (2005) From nociception to pain perception: imaging the spinal and supraspinal pathways. J Anat 207:19–33
Kwan CL, Crawley AP, Mikulis DJ, Davis KD (2000) An fMRI study of the anterior cingulate cortex and surrounding medial wall activations evoked by noxious cutaneous heat and cold stimuli. Pain 85:359–374
Moulton EA, Keaser ML, Gullapalli RP, Greenspan JD (2005) Regional intensive and temporal patterns of functional MRI activation distinguishing noxious and innocuous contact heat. J Neurophysiol 93:2183–2193
Darsow U, Drzezga A, Frisch M, Munz F, Weilke F, Bartenstein P, Schwaiger M, Ring J (2000) Processing of histamine-induced itch in the human cerebral cortex: a correlation analysis with dermal reactions. J Invest Dermatol 115:1029–1033
Drzezga A, Darsow U, Treede R, Siebner H, Frisch M, Munz F, Weilke F, Ring J, Schwaiger M, Bartenstein P (2001) Central activation by histamine-induced itch: analogies to pain processing: a correlational analysis of O-15 H(2)O positron emission tomography studies. Pain 92:295–305
Hsieh JC, Hagermark O, Stahle Backdahl M, Ericson K, Eriksson L, Stone Elander S, Ingvar M (1994) Urge to scratch represented in the human cerebral cortex during itch. J Neurophysiol 72:3004–3008
Nilsson HJ, Levinsson A, Schouenborg J (1997) Cutaneous field stimulation (CFS): a new powerful method to combat itch. Pain 71:49–55
Brull SJ, Atanassoff PG, Silverman DG, Zhang J, LaMotte RH (1999) Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia. Somatosens Mot Res 16:299–303
Yosipovitch G, Fast K, Bernhard JD (2005) Noxious heat and scratching decrease histamine-induced itch and skin blood flow. J Invest Dermatol 125:1268–1272
Pfab F, Valet M, Sprenger T, Toelle TR, Athanasiadis GI, Behrendt H, Ring J, Darsow U (2006) Short-term alternating temperature enhances histamine-induced itch: a biphasic stimulus model. J Invest Dermatol 126:2673–2678
Atanassoff PG, Brull SJ, Zhang J, Greenquist K, Silverman DG, LaMotte RH (1999) Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia. Somatosens Mot Res 16:291–298
Ballantyne JC, Loach AB, Carr DB (1988) Itching after epi-dural and spinal opiates. Pain 33:149–160
Ko MC, Song MS, Edwards T, Lee H, Naughton NN (2004) The role of central mu opioid receptors in opioid-induced itch in primates. J Pharmacol Exp Ther 310:169–176
McRae CA, Prince MI, Hudson M, Day CP, James OF, Jones DE (2003) Pain as a complication of use of opiate antagonists for symptom control in cholestasis. Gastroenterology 125:591–596
Kamei J, Nagase H (2001) Norbinaltorphimine, a selective kappa-opioid receptor antagonist, induces an itch-associated response in mice. Eur J Pharmacol 418:141–145
Ko MC, Lee H, Song MS, Sobczyk-Kojiro K, Mosberg HI, Kishioka S, Woods JH, Naughton NN (2003) Activation of kappa-opioid receptors inhibits pruritus evoked by subcutaneous or intrathecal administration of morphine in monkeys. J Pharmacol Exp Ther 305:173–179
Wikstrom B, Gellert R, Ladefoged SD, Danda Y, Akai M, Ide K, Ogasawara M, Kawashima Y, Ueno K, Mori A, Ueno Y (2005) Kappa-opioid system in uremic pruritus: multicenter, randomized, double-blind, placebo-controlled clinical studies. J Am Soc Nephrol 16:3742–3747
Kumagai H, Matsukawa S, Utsumi J, Saruta T (2004) Prospects for a novel opioid kappa receptor agonist TRK-820 in uremic pruritus. In: Yosipovitch G., Greaves MW, Fleischer AB Jr, McGlone F (eds) Itch— basic mechanisms and therapy. Marcel Dekker, New York
Ikoma A, Rukwied R, Stander S, Steinhoff M, Miyachi Y, Schmelz M (2003) Neuronal sensitization for histamine-induced itch in lesional skin of patients with atopic dermatitis. Arch Dermatol 139:1455–1458
Kidd BL, Urban LA (2001) Mechanisms of inflammatory pain. Br J Anaesth 87:3–11
Toyoda M, Nakamura M, Makino T, Hino T, Kagoura M, Morohashi M (2002) Nerve growth factor and substance P are useful plasma markers of disease activity in atopic dermatitis. Br J Dermatol 147:71–79
Bohm-Starke N, Hilliges M, Falconer C, Rylander E (1998) Increased intraepithelial innervation in women with vulvar vestibulitis syndrome. Gynecol Obstet Invest 46:256–260
Urashima R, Mihara M (1998) Cutaneous nerves in atopic dermatitis. A histological, immunohistochemical and electron microscopic study. Virchows Arch 432:363–370
Koltzenburg M (2000) Neural mechanisms of cutaneous nociceptive pain. Clin J Pain 16:S131–S138
Schmelz M, Hilliges M, Schmidt R, Orstavik K, Vahlquist C, Weidner C, Handwerker HO, Torebjork HE (2003) Active “itch fibers” in chronic pruritus. Neurology 61:564–566
Ikoma A, Fartasch M, Heyer G, Miyachi Y, Handwerker H, Schmelz M (2004) Painful stimuli evoke itch in patients with chronic pruritus: central sensitization for itch. Neurology 62:212–217
Baron R, Schwarz K, Kleinert A, Schattschneider J, Wasner G (2001) Histamine-induced itch converts into pain in neuropathic hyperalgesia. Neuroreport 12:3475–3478
Neisius U, Olsson R, Rukwied R, Lischetzki G, Schmelz M (2002) Prostaglandin E2 induces vasodilation and pruritus, but no protein extravasation in atopic dermatitis and controls. J Am Acad Dermatol 47:28–32
Steinhoff M, Neisius U, Ikoma A, Fartasch M, Heyer G, Skov PS, Luger TA, Schmelz M (2003) Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin. J Neurosci 23:6176–6180
Vergnolle N, Bunnett NW, Sharkey KA, Brussee V, Compton SJ, Grady EF, Cirino G, Gerard N, Basbaum AI, Andrade-Gordon P, Hollenberg MD, Wallace JL (2001) Proteinase-activated receptor-2 and hyperalgesia: a novel pain pathway. Nat Med 7:821–826
Vogelsang M, Heyer G, Hornstein OP (1995) Acetylcholine induces different cutaneous sensations in atopic and non-atopic subjects. Acta Derm Venereol 75:434–436
Hosogi M, Schmelz M, Miyachi Y, Ikoma A (2006) Bradykinin is a potent pruritogen in atopic dermatitis: a switch from pain to itch. Pain 126:16–23
Stander S, Steinhoff M (2002) Pathophysiology of pruritus in atopic dermatitis: an overview. Exp Dermatol 11:12–24
Andoh T, Kuraishi Y (1998) Intradermal leukotriene B4, but not prostaglandin E2, induces itch-associated responses in mice. Eur J Pharmacol 353:93–96
Kuraishi Y, Nagasawa T, Hayashi K, Satoh M (1995) Scratching behavior induced by pruritogenic but not algesio-genic agents in mice. Eur J Pharmacol 275:229–233
Weidner C, Klede M, Rukwied R, Lischetzki G, Neisius U, Skov PS, Petersen LJ, Schmelz M (2000) Acute effects of substance P and calcitonin gene-related peptide in human skin— a microdialysis study. J Invest Dermatol 115:1015–1020
Yosipovitch G, Greaves M, Schmelz M (2003) Itch. Lancet 361:690–694
Peer G, Kivity S, Agami O, Fireman E, Silverberg D, Blum M, Laina A (1996) Randomised crossover trial of naltrexone in uraemic pruritus. Lancet 348:1552–1554
Togashi Y, Umeuchi H, Okano K, Ando N, Yoshizawa Y, Honda T, Kawamura K, Endoh T, Utsumi J, Kamei J, Tanaka T, Nagase H (2002) Antipruritic activity of the [kappa]-opi-oid receptor agonist, TRK-820. Eur J Pharmacol 435:259–264
Oaklander AL, Cohen SP, Raju SV (2002) Intractable pos-therpetic itch and cutaneous deafferentation after facial shingles. Pain 96:9–12
Goodkin R, Wingard E, Bernhard JD (2003) Brachioradial pruritus: cervical spine disease and neurogenic/neuropathic [corrected] pruritus. J Am Acad Dermatol 48:521–524
Sandyk R (1994) Paroxysmal itching in multiple sclerosis during treatment with external magnetic fields. Int J Neurosci 75:65–71
Savk O, Savk E (2005) Investigation of spinal pathology in notalgia paresthetica. J Am Acad Dermatol 52:1085–1087
Klein PA, Clark RA (1999) An evidence-based review of the efficacy of antihistamines in relieving pruritus in atopic dermatitis. Arch Dermatol 135:1522–1525
Bell JK, Mcqueen DS, Rees JL (2004) Involvement of histamine H4 and H1 receptors in scratching induced by histamine receptor agonists in Balb C mice. Br J Pharmacol 142:374–380
Sevcik MA, Ghilardi JR, Peters CM, Lindsay TH, Halvorson KG, Jonas BM, Kubota K, Kuskowski MA, Boustany L, Shelton DL, Mantyh PW (2005) Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization. Pain 115:128–141
Lane N, Webster L, Lu SP, Gray M, Hefti F, Walicke P (2005) RN624 (anti-NGF) improves pain and function in subjects with moderate knee osteoarthritis: a phase I study. In: Osteoarthritis— clinical aspects. Proceedings american college of rheumatology, San Diego, 1205
Takano N, Sakurai T, Kurachi M (2005) Effects of anti-nerve growth factor antibody on symptoms in the NC/Nga mouse, an atopic dermatitis model. J Pharmacol Sci 99:277–286
Kelly KM (1998) Gabapentin. Antiepileptic mechanism of action. Neuropsychobiology 38:139–144
Jensen TS (2002) Anticonvulsants in neuropathic pain: rationale and clinical evidence. Eur J Pain 6(Suppl A): 61–68
Winhoven SM, Coulson IH, Bottomley WW (2004) Brachioradial pruritus: response to treatment with gabapen-tin. Br J Dermatol 150:786–787
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Ikoma, A. (2010). Neurophysiology of Itch. In: Krieg, T., Bickers, D.R., Miyachi, Y. (eds) Therapy of Skin Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-78814-0_13
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