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Immunology, Phenotype First: How Mutations Have Established New Principles and Pathways in Immunology pp 101–122Cite as

Cmv1 and Natural Killer Cell Responses to Murine Cytomegalovirus Infection

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 321))

Abstract

The dissection of genetic resistance to murine cytomegalovirus infection in inbred laboratory mouse strains led to the identification of a natural killer cell activation receptor that recognizes a virus-encoded protein. Herein, we summarize the genetic approach and findings that have provided novel insights into innate immune control of virus infections.

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Abbreviations

CMV:

Cytomegalovirus

DAP12:

DNAX activating protein of 12 kDa

Δm157:

MCMV clone lacking m157 expression

ENU:

N-Ethyl-N-nitrosourea

GFP:

Green fluorescent protein

HCMV:

Human CMV

Ig:

Immunoglobulin

ILT:

Ig-like transcripts

ITAM:

Immunoreceptor tyrosine-based activation motif

ITIM:

Immunoreceptor tyrosine-based inhibitory motif

KARAP:

Killer associated receptor adapter protein

KIR:

Killer Ig-like receptor

LCMV:

Lymphocytic choriomeningitis virus

MCMV:

Murine CMV

mAb:

Monoclonal antibody

MHC:

Major histocompatibility complex

NK:

Natural killer

NKC:

NK gene complex

ORF:

Open reading frame

RI:

Recombinant inbred

SCID-MCMV:

MCMV clones isolated from scid mice

TLR:

Toll-like receptor

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Authors and Affiliations

  1. Immunology and Virology Program, Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, 2 Verdun Street, Nedlands, WA, 6009, Australia

    A. A. Scalzo

  2. Howard Hughes Medical Institute, Division of Rheumatology, Washington University School of Medicine, Campus Box 8045, 660 South Euclid Avenue, St. Louis, MO, 63110, USA

    W. M. Yokoyama

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  1. A. A. Scalzo
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  2. W. M. Yokoyama
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Correspondence to W. M. Yokoyama .

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  1. Department of Immunology, Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA, 92037, USA

    Bruce Beutler

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Scalzo, A.A., Yokoyama, W.M. (2008). Cmv1 and Natural Killer Cell Responses to Murine Cytomegalovirus Infection. In: Beutler, B. (eds) Immunology, Phenotype First: How Mutations Have Established New Principles and Pathways in Immunology. Current Topics in Microbiology and Immunology, vol 321. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-75203-5_5

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