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Delineation of Cerebrocerebellar Networks with MRI Measures of Functional and Structural Connectivity

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Handbook of the Cerebellum and Cerebellar Disorders

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Abstract

In humans, resting-state functional connectivity MRI (fcMRI) allows precise in vivo delineation of the neocerebellum’s participation in well-segregated, nonmotor intrinsic connectivity networks (ICNs). These data reveal that the neocerebellum participates in several ICNs, including the default mode network (lobule IX), the salience network (lobule VI), and the right and left executive networks (crus I and II). Additionally, fcMRI permits an anatomical parcellation of the neocerebellum based on its specific functional links with the associative cortex. Lobules V, VII, IX, and especially crus I and II constitute a supramodal cognitive zone specifically interconnected with prefrontal, parietal, and cingulate neocortices. Structural connectivity using DTI-based tractography complements fcMRI data and confirms anatomical connections between the dentate nucleus, thalamus, and associative cortices. Taken together, these results support the theory that specific neocerebellar subregions are key nodes in parallel, multisynaptic, closed-loop circuits involved in executive, mnemonic, and affective functions.

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Author information

Authors and Affiliations

  1. Service de NeuroImagerie, CHNO des XV–XX, Université Pierre et Marie Curie Paris 6, Paris, France

    Christophe Habas

  2. Department of Neurology and Neurological Sciences, Functional Imaging in Neuropsychiatric Disorders (FIND) Lab, Stanford University School of Medicine, Stanford, CA, USA

    William R. Shirer & Michael D. Greicius

Authors
  1. Christophe Habas
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  2. William R. Shirer
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  3. Michael D. Greicius
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Corresponding author

Correspondence to Christophe Habas .

Editor information

Editors and Affiliations

  1. Bruxelles, Belgium

    Mario Manto

  2. Scripps Research Institute Dept. Neuropharmacology, La Jolla, CA, USA

    Donna Gruol

  3. Dept. Neurology, Harvard Medical School Massachusetts General Hospital, Boston, MA, USA

    Jeremy Schmahmann

  4. Gunma University Dept. Integrative Physiology, Maebashi, Gunma, Japan

    Noriyuki Koibuchi

  5. Dept Pathology & Immunology & Neuro, Baylor College of Medicine Dept Pathology & Immunology & Neuro, Houston, TX, USA

    Roy Sillitoe

Section Editor information

  1. Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Jeremy D. Schmahmann

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Habas, C., Shirer, W.R., Greicius, M.D. (2019). Delineation of Cerebrocerebellar Networks with MRI Measures of Functional and Structural Connectivity. In: Manto, M., Gruol, D., Schmahmann, J., Koibuchi, N., Sillitoe, R. (eds) Handbook of the Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-97911-3_26-2

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  • DOI: https://doi.org/10.1007/978-3-319-97911-3_26-2

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  • Print ISBN: 978-3-319-97911-3

  • Online ISBN: 978-3-319-97911-3

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