Abstract
In the cerebellum, both astrocytes and oligodendrocytes are characterized by a peculiar heterogeneity. Astrocytes include Bergmann glia, granular layer, and white matter astrocyte types, each endowed with specific morphological and functional features; oligodendrocytes derive from multiple embryonic sources and establish neuron type-specific interactions. Nevertheless, while the mechanisms of neuronal diversification have been deeply investigated and in part elucidated, gliogenesis in the cerebellum remains poorly explored. Here, we critically discuss the available knowledge regarding the ontogenesis of the repertoire of glial cells in the cerebellum, their relationships with cerebellar neurons, and the processes regulating the acquisition of their mature morphological and molecular traits, pointing out the open questions that still seek elucidation.
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Abbreviations
- BG:
-
Bergmann glia
- EGL:
-
External granular layer
- PC:
-
Purkinje cell
- PCL:
-
Purkinje cell layer
- PWM:
-
Prospective white matter
- RG:
-
Radial glia
- RL:
-
Rhombic lip
- VZ:
-
Ventricular zone
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This work was funded by local grants of the University of Turin. VC was partly supported by a FENS fellowship.
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Cerrato, V., Buffo, A. (2019). Gliogenesis. In: Manto, M., Gruol, D., Schmahmann, J., Koibuchi, N., Sillitoe, R. (eds) Handbook of the Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-97911-3_108-2
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Gliogenesis- Published:
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DOI: https://doi.org/10.1007/978-3-319-97911-3_108-2
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DOI: https://doi.org/10.1007/978-3-319-97911-3_108-1