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Predictive Biomarkers in Oncology pp 345–351Cite as

Role of Protein Tyrosine Phosphatases in Cancer Signaling

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Abstract

Protein tyrosine phosphatases (PTPs) constitute a large family of enzymes that can exert both positive and negative effects on signaling pathways. With 107 members, the PTP gene family is one of the most diverse in the mammalian genome. Since most previously described oncogenes were kinases, it was logical to postulate that PTPs would, therefore, act as tumor suppressor genes. However, it is now clear that within the PTP family there are also many pro-oncogenic enzymes. Herein, we selected five key PTPs (PTEN, SHP2, PRL, TC-PTP, PTP1B) known to modulate oncogenic signaling which are therefore of great interest as predictive markers. Despite 40 years of research since their discovery, the PTP gene family remains poorly characterized. With their increasingly recognized function in cancer cell signaling, we should expect that PTPs will be further used as biomarkers and therapeutic targets.

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Authors and Affiliations

  1. Department of Biochemistry, Goodman Cancer Research Center, McGill University, Montreal, QC, Canada

    Elie Kostantin, Yevgen Zolotarov & Michel L. Tremblay

Authors
  1. Elie Kostantin
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  2. Yevgen Zolotarov
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  3. Michel L. Tremblay
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Corresponding author

Correspondence to Michel L. Tremblay .

Editor information

Editors and Affiliations

  1. Department of Pathology and Lab Medicine, Indiana University School of Medicine, Indianapolis, IN, USA

    Sunil Badve

  2. Targos Inc., Issaquah, WA, USA

    George Louis Kumar

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Kostantin, E., Zolotarov, Y., Tremblay, M.L. (2019). Role of Protein Tyrosine Phosphatases in Cancer Signaling. In: Badve, S., Kumar, G. (eds) Predictive Biomarkers in Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-95228-4_30

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  • DOI: https://doi.org/10.1007/978-3-319-95228-4_30

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-95227-7

  • Online ISBN: 978-3-319-95228-4

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