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Antidiabetic and Antioxidant Activities of Bioactive Compounds from Endophytes

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Endophytes and Secondary Metabolites

Part of the book series: Reference Series in Phytochemistry ((RSP))

Abstract

The aim of the present chapter is to appraise the phytochemical and pharmacological potential of the endophytes. This chapter will further highlight the future research prospects of the study of endophytes with antioxidant and antidiabetic activities. Informations on endophytes were obtained from related publications using electronic scientific databases. Based on previous reports, it could be said that the endophytes have emerged as excellent source of compounds which could be used for the treatment of skin diseases and microbial infections and as anticancer and anti-inflammatory agents. The studies provide new knowledge on the isolation and characterization of novel bioactives especially in the discovery of novel therapeutic drugs with antioxidant and antidiabetic properties. however, current research on the pharmacological properties of all the endophyte species including bioassay-guided isolation of phytoconstituents and their mechanism of action, pharmacokinetics, bioavailability, efficacy, and safety should be carried out in the future to add more value to this study.

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Abbreviations

ABTS:

2,2-Azinobis(3-ethylbenzothiazoline-6-sulfonic acid)

AGEs:

Advanced glycation end products

AgNPs:

Silver nanoparticles

ALP:

Alkaline phosphatase

ALT:

Alanine aminotransferase

AMPK:

AMP-activated protein kinase

AST:

Aspartate aminotransferase

CAT:

Catalase

CE6:

Not identified

CE9:

Not identified

CEC12:

Cochliobolus sp.

CED3:

Diaporthe sp.

CED4:

Diaporthe sp.

CED7:

Diaporthe sp.

CEDp11:

Diaporthe phaseolorum

CEDp2:

Diaporthe phaseolorum

CEP1:

Phomopsis sp.

CEP10:

Phomopsis sp.

CEP4:

Phomopsis sp.

CES13:

Sordariomycetes sp.

CES8:

Sordariomycetes sp.

CVD:

Cardiovascular diseases

DAPG:

2,4-Diacetylphloroglucinol

DPPH:

1,1-Diphenyl-2-picrylhydrazyl

EtOAc:

Ethyl acetate

FRAP:

Ferric reducing ability of plasma

FTIR:

Fourier-transform infrared spectroscopy

GC-MS:

Gas chromatography mass spectrometry

GPx:

Glutathione peroxidase

ITS:

Internal transcribed spacer

MDA:

Malondialdehyde

NCB:

Gene sequencing

PMS-NADH:

Phenazine methosulfate-nicotinamide adenine dinucleotide

ROS:

Reactive oxygen species

SOD:

Superoxide dismutase

T2D:

Type 2 diabetes mellitus

TEM:

Transmission electron microscopy

UV-Vis:

Ultraviolet-visible spectroscopy

VOLF4:

Aspergillus sp.

VOLF5:

Peniophora sp.

VOR5:

Fusarium nematophilum

XRD:

X-ray diffraction

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Authors and Affiliations

  1. Laboratorio de Investigación de Productos Naturales, Escuela Superior de Ingenieria Quimica e Industrias Extractivas, Instituto Politecnico Nacional (IPN) Unidad Profesional Adolfo Lopez Mateos S/N Av, Instituto Politécnico Nacional Ciudad de Mexico, Mexico City, Mexico

    Rosa Martha Perez Gutierrez

  2. Laboratorio de Productos Naturales, Instituto de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City, Mexico

    Adriana Neira González

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  1. Rosa Martha Perez Gutierrez
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  2. Adriana Neira González
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Correspondence to Rosa Martha Perez Gutierrez .

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  1. Department of Botany, University of Calcutta, Kolkata, West Bengal, India

    Sumita Jha

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Perez Gutierrez, R.M., Neira González, A. (2019). Antidiabetic and Antioxidant Activities of Bioactive Compounds from Endophytes. In: Jha, S. (eds) Endophytes and Secondary Metabolites. Reference Series in Phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-319-90484-9_30

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