Skip to main content

Cardiovascular Pharmacology in Adult Patients Undergoing Cardiac Surgery

  • Chapter
  • First Online:

Abstract

The word “drug” originated from a French word “drogue,” which also came from “droge-vate” from Middle Dutch meaning “dry barrels” (Harper, Douglas. “drug ”. Online Etymology Dictionary ). This concept is referring to the preservation of pharmaceutical plants in barrels. As Claude Bernard quoted in 1865, “everything is poisonous, nothing is poisonous, and it is all a matter of dose” (Bernard, Claude. An introduction to the study of experimental study; 1865). Therefore in this chapter, we are reviewing some clinical pharmacological titles including inotropes, vasoactive agents, diuretics, antihypertensive agents, anti-arrhythmic agents, anesthetic drugs, agents affecting autonomic nervous systems, anticoagulation and thrombolysis drugs, blood products, and antibiotics.

In this chapter, we emphasize on main clinical consideration and dosage in addition to indications and contraindications, in other words when will the drug be poisonous as quoted above. The aim of this chapter is to have a practical, clinical, and logical approach in pharmaceutical management of patients with heart disease.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   299.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Abman SH, Hansmann G, Archer SL, Ivy DD, Adatia I, Chung WK, Hanna BD, Rosenzweig EB, Raj JU, Cornfield D, Stenmark KR, Steinhorn R, Thebaud B, Fineman JR, Kuehne T, Feinstein JA, Friedberg MK, Earing M, Barst RJ, Keller RL, Kinsella JP, Mullen M, Deterding R, Kulik T, Mallory G, Humpl T, Wessel DL. Pediatric pulmonary hypertension: guidelines from the american heart association and american thoracic society. Circulation. 2015;132:2037–99.

    Article  PubMed  Google Scholar 

  • Ageno W, Gallus AS, Wittkowsky A, Crowther M, Hylek EM, Palareti G. Oral anticoagulant therapy: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141:e44S–88S.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Al-Naher A, Wright D, Devonald MAJ, Pirmohamed M. Renal function monitoring in heart failure—what is the optimal frequency? A narrative review. Br J Clin Pharmacol. 2017;84(1):5–17.

    Article  PubMed  PubMed Central  Google Scholar 

  • Allen HD, Driscoll DJ, Shaddy RE, Feltes TF. Moss & Adams’ heart disease in infants, children, and adolescents: including the fetus and young adult. Philadelphia, PA: Lippincott Williams & Wilkins; 2013.

    Google Scholar 

  • Allpress AL, Rosenthal GL, Goodrich KM, Lupinetti FM, Zerr DM. Risk factors for surgical site infections after pediatric cardiovascular surgery. Pediatr Infect Dis J. 2004;23:231–4.

    Article  PubMed  Google Scholar 

  • Amanfu RK, Saucerman JJ. Cardiac models in drug discovery and development: a review. Crit Rev Biomed Eng. 2011;39:379–95.

    Article  PubMed  PubMed Central  Google Scholar 

  • Arora TK, Arora AK, Sachdeva MK, Rajput SK, Sharma AK. Pulmonary hypertension: molecular aspects of current therapeutic intervention and future direction. J Cell Physiol. 2017. https://doi.org/10.1002/jcp.26191.

  • Atkins DL, Berger S, Duff JP, Gonzales JC, Hunt EA, Joyner BL, Meaney PA, Niles DE, Samson RA, Schexnayder SM. Part 11: pediatric basic life support and cardiopulmonary resuscitation quality: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2015;132:S519–25.

    Article  PubMed  Google Scholar 

  • Atz AM, Wessel DL. Inhaled nitric oxide in the neonate with cardiac disease. Semin Perinatol. 1997;21:441–55.

    Article  PubMed  CAS  Google Scholar 

  • Bangash MN, Kong ML, Pearse RM. Use of inotropes and vasopressor agents in critically ill patients. Br J Pharmacol. 2012;165:2015–33.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bayat F, Faritous Z, Aghdaei N, Dabbagh A. A study of the efficacy of furosemide as a prophylaxis of acute renal failure in coronary artery bypass grafting patients: a clinical trial. ARYA Atheroscler. 2015;11:173–8.

    PubMed  PubMed Central  Google Scholar 

  • Beck G, Brinkkoetter P, Hanusch C, Schulte J, van Ackern K, van der Woude FJ, Yard BA. Clinical review: immunomodulatory effects of dopamine in general inflammation. Crit Care. 2004;8:485–91.

    Article  PubMed  Google Scholar 

  • Beghetti M, Wacker Bou Puigdefabregas J, Merali S. Sildenafil for the treatment of pulmonary hypertension in children. Expert Rev Cardiovasc Ther. 2014;12:1157–84.

    Article  PubMed  CAS  Google Scholar 

  • Begum N, Shen W, Manganiello V. Role of PDE3A in regulation of cell cycle progression in mouse vascular smooth muscle cells and oocytes: implications in cardiovascular diseases and infertility. Curr Opin Pharmacol. 2011;11:725–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bianchi MO, Cheung PY, Phillipos E, Aranha-Netto A, Joynt C. The effect of milrinone on splanchnic and cerebral perfusion in infants with congenital heart disease prior to surgery: an observational study. Shock. 2015;44:115–20.

    Article  PubMed  CAS  Google Scholar 

  • Biban P, Gaffuri M. Vasopressin and terlipressin in neonates and children with refractory septic shock. Curr Drug Metab. 2013;14:186–92.

    PubMed  CAS  Google Scholar 

  • Bihari D, Prakash S, Bersten A. Low-dose vasopressin in addition to noradrenaline may lead to faster resolution of organ failure in patients with severe sepsis/septic shock. Anaesth Intensive Care. 2014;42:671–4.

    PubMed  CAS  Google Scholar 

  • Bomb R, Oliphant CS, Khouzam RN. Dual antiplatelet therapy after coronary artery bypass grafting in the setting of acute coronary syndrome. Am J Cardiol. 2015;116:148–54.

    Article  PubMed  Google Scholar 

  • Bond R, Olshansky B, Kirchhof P. Recent advances in rhythm control for atrial fibrillation. F1000Res. 2017;6:1796.

    Article  PubMed  PubMed Central  Google Scholar 

  • Bourenne J, Hraiech S, Roch A, Gainnier M, Papazian L, Forel JM. Sedation and neuromuscular blocking agents in acute respiratory distress syndrome. Ann Transl Med. 2017;5:291.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bracht H, Calzia E, Georgieff M, Singer J, Radermacher P, Russell JA. Inotropes and vasopressors: more than haemodynamics! Br J Pharmacol. 2012;165:2009–11.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Brissaud O, Botte A, Cambonie G, Dauger S, de Saint Blanquat L, Durand P, Gournay V, Guillet E, Laux D, Leclerc F, Mauriat P, Boulain T, Kuteifan K. Experts’ recommendations for the management of cardiogenic shock in children. Ann Intensive Care. 2016;6:14.

    Article  PubMed  PubMed Central  Google Scholar 

  • Brunner N, de Jesus Perez VA, Richter A, Haddad F, Denault A, Rojas V, Yuan K, Orcholski M, Liao X. Perioperative pharmacological management of pulmonary hypertensive crisis during congenital heart surgery. Pulm Circ. 2014;4:10–24.

    Article  PubMed  PubMed Central  Google Scholar 

  • Bucher BT, Warner BW, Dillon PA. Antibiotic prophylaxis and the prevention of surgical site infection. Curr Opin Pediatr. 2011;23:334–8.

    Article  PubMed  Google Scholar 

  • Cannesson M, Jian Z, Chen G, Vu TQ, Hatib F. Effects of phenylephrine on cardiac output and venous return depend on the position of the heart on the Frank-Starling relationship. J Appl Physiol. 2012;113:281–9.

    Article  PubMed  CAS  Google Scholar 

  • Capodanno D, Bhatt DL, Goto S, O’Donoghue ML, Moliterno DJ, Tamburino C, Angiolillo DJ. Safety and efficacy of protease-activated receptor-1 antagonists in patients with coronary artery disease: a meta-analysis of randomized clinical trials. J Thromb Haemost. 2012;10:2006–15.

    Article  PubMed  CAS  Google Scholar 

  • Carroll SJ, Ferris A, Chen J, Liberman L. Efficacy of prostaglandin E1 in relieving obstruction in coarctation of a persistent fifth aortic arch without opening the ductus arteriosus. Pediatr Cardiol. 2006;27:766–8.

    Article  PubMed  Google Scholar 

  • Cata JP, Ramirez MF, Velasquez JF, Di AI, Popat KU, Gottumukkala V, Black DM, Lewis VO, Vauthey JN. Lidocaine stimulates the function of natural killer cells in different experimental settings. Anticancer Res. 2017;37:4727–32.

    PubMed  Google Scholar 

  • Chan MJ, Chung T, Glassford NJ, Bellomo R. Near-infrared spectroscopy in adult cardiac surgery patients: a systematic review and meta-analysis. J Cardiothorac Vasc Anesth. 2017;31:1155–65.

    Article  PubMed  Google Scholar 

  • Chaturvedi S, Lipszyc DH, Licht C, Craig JC, Parekh R. Pharmacological interventions for hypertension in children. Cochrane Database Syst Rev. 2014a;2:Cd008117.

    Google Scholar 

  • Chaturvedi S, Lipszyc DH, Licht C, Craig JC, Parekh R. Pharmacological interventions for hypertension in children. Cochrane Database Syst Rev. 2014b;9:498–580.

    Google Scholar 

  • Chierchia S, Davies G, Berkenboom G, Crea F, Crean P, Maseri A. Alpha-adrenergic receptors and coronary spasm: an elusive link. Circulation. 1984;69:8–14.

    Article  PubMed  CAS  Google Scholar 

  • Chong LYZ, Satya K, Kim B, Berkowitz R. Milrinone dosing and a culture of caution in clinical practice. Cardiol Rev. 2018;26(1):35–42.

    Article  PubMed  Google Scholar 

  • Choong K, Kissoon N. Vasopressin in pediatric shock and cardiac arrest. Pediatr Crit Care Med. 2008;9:372–9.

    Article  PubMed  Google Scholar 

  • Chu PY, Campbell MJ, Miller SG, Hill KD. Anti-hypertensive drugs in children and adolescents. World J Cardiol. 2014;6:234–44.

    Article  PubMed  PubMed Central  Google Scholar 

  • CID=681 NCfBIPCD. 2016. Dopamine.

    Google Scholar 

  • Clutter WE, Bier DM, Shah SD, Cryer PE. Epinephrine plasma metabolic clearance rates and physiologic thresholds for metabolic and hemodynamic actions in man. J Clin Invest. 1980;66:94–101.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Cooper BE. Review and update on inotropes and vasopressors. AACN Adv Crit Care. 2008;19:5–13; quiz 14–15.

    PubMed  Google Scholar 

  • Costello JM, Graham DA, Morrow DF, Morrow J, Potter-Bynoe G, Sandora TJ, Pigula FA, Laussen PC. Risk factors for surgical site infection after cardiac surgery in children. Ann Thorac Surg. 2010;89:1833–41; discussion 1841–1832.

    Article  PubMed  Google Scholar 

  • Cruickshank JM. The role of beta-blockers in the treatment of hypertension. Adv Exp Med Biol. 2017;956:149–66.

    Article  PubMed  Google Scholar 

  • Cuthbert AW. Lubiprostone targets prostanoid EP(4) receptors in ovine airways. Br J Pharmacol. 2011;162:508–20.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Dabbagh A. Cardiac physiology. In: Dabbagh A, Esmailian F, Aranki S, editors. Postoperative critical care for cardiac surgical patients. 1st ed. Berlin: Springer; 2014. p. 1–39.

    Chapter  Google Scholar 

  • Dabbagh A, Talebi Z, Rajaei S. Cardiovascular pharmacology i heart disease. In: Dabbagh A, Conte AH, Lubin L, editors. Congenital heart disease in pediatric and adult patients: anesthetic and perioperative management. 1st ed. Berlin: Springer; 2017a. p. 117–95.

    Chapter  Google Scholar 

  • Dabbagh A, Imani A, Rajaei S. Pediatric cardiovascular physiology. In: Dabbagh A, Conte AH, Lubin L, editors. Congenital heart disease in pediatric and adult patients: anesthetic and perioperative management. 1st ed. Berlin: Springer; 2017b. p. 65–116.

    Chapter  Google Scholar 

  • De Backer D, Biston P, Devriendt J, Madl C, Chochrad D, Aldecoa C, Brasseur A, Defrance P, Gottignies P, Vincent JL. Comparison of dopamine and norepinephrine in the treatment of shock. N Engl J Med. 2010;362:779–89.

    Article  PubMed  Google Scholar 

  • de Caen AR, Berg MD, Chameides L, Gooden CK, Hickey RW, Scott HF, Sutton RM, Tijssen JA, Topjian A, van der Jagt EW, Schexnayder SM, Samson RA. Part 12: pediatric advanced life support: 2015 American Heart Association guidelines update for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2015;132:S526–42.

    Article  PubMed  PubMed Central  Google Scholar 

  • Degrauwe S, Pilgrim T, Aminian A, Noble S, Meier P, Iglesias JF. Dual antiplatelet therapy for secondary prevention of coronary artery disease. Open Heart. 2017;4:e000651.

    Article  PubMed  PubMed Central  Google Scholar 

  • Desborough MJ, Oakland K, Brierley C, Bennett S, Doree C, Trivella M, Hopewell S, Stanworth SJ, Estcourt LJ. Desmopressin use for minimising perioperative blood transfusion. Cochrane Database Syst Rev. 2017;7:Cd001884.

    PubMed  Google Scholar 

  • Dhull RS, Baracco R, Jain A, Mattoo TK. Pharmacologic treatment of pediatric hypertension. Curr Hypertens Rep. 2016;18:32.

    Article  PubMed  CAS  Google Scholar 

  • Dixon BS, Beck GJ, Vazquez MA, Greenberg A, Delmez JA, Allon M, Dember LM, Himmelfarb J, Gassman JJ, Greene T, Radeva MK, Davidson IJ, Ikizler TA, Braden GL, Fenves AZ, Kaufman JS, Cotton JR Jr, Martin KJ, McNeil JW, Rahman A, Lawson JH, Whiting JF, Hu B, Meyers CM, Kusek JW, Feldman HI. Effect of dipyridamole plus aspirin on hemodialysis graft patency. N Engl J Med. 2009;360:2191–201.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Dodgen AL, Hill KD. Safety and tolerability considerations in the use of sildenafil for children with pulmonary arterial hypertension. Drug Healthc Patient Saf. 2015;7:175–83.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Driscoll A, Currey J, Tonkin A, Krum H. Nurse-led titration of angiotensin converting enzyme inhibitors, beta-adrenergic blocking agents, and angiotensin receptor blockers for people with heart failure with reduced ejection fraction. Cochrane Database Syst Rev. 2015;12:Cd009889.

    Google Scholar 

  • Duman E, Karakoc F, Pinar HU, Dogan R, Firat A, Yildirim E. Higher dose intra-arterial milrinone and intra-arterial combined milrinone-nimodipine infusion as a rescue therapy for refractory cerebral vasospasm. Interv Neuroradiol. 2017;23(6):636–43.

    Article  PubMed  PubMed Central  Google Scholar 

  • Eaton MP. Antifibrinolytic therapy in surgery for congenital heart disease. Anesth Analg. 2008;106:1087–100.

    Article  PubMed  CAS  Google Scholar 

  • Eftekhar-Vaghefi S, Esmaeili-Mahani S, Elyasi L, Abbasnejad M. Involvement of mu opioid receptor signaling in the protective effect of opioid against 6-hydroxydopamine-induced SH-SY5Y human neuroblastoma cells apoptosis. Basic Clin Neurosci. 2015;6:171–8.

    PubMed  PubMed Central  Google Scholar 

  • Ehlert A, Manthei G, Hesselmann V, Mathias K, Bein B, Pluta R. A case of hyperacute onset of vasospasm after aneurysmal subarachnoid hemorrhage and refractory vasospasm treated with intravenous and intraventricular nitric oxide: a mini review. World Neurosurg. 2016;91:673.e611–8.e611.

    Article  Google Scholar 

  • Elenkov IJ, Wilder RL, Chrousos GP, Vizi ES. The sympathetic nerve—an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev. 2000;52:595–638.

    PubMed  CAS  Google Scholar 

  • Faraoni D, Goobie SM. The efficacy of antifibrinolytic drugs in children undergoing noncardiac surgery: a systematic review of the literature. Anesth Analg. 2014;118:628–36.

    Article  PubMed  CAS  Google Scholar 

  • Feng AY, Kaye AD, Kaye RJ, Belani K, Urman RD. Novel propofol derivatives and implications for anesthesia practice. J Anaesthesiol Clin Pharmacol. 2017;33:9–15.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ferrer-Barba A, Gonzalez-Rivera I, Bautista-Hernandez V. Inodilators in the management of low cardiac output syndrome after pediatric cardiac surgery. Curr Vasc Pharmacol. 2016;14:48–57.

    Article  PubMed  CAS  Google Scholar 

  • Fleming GA, Murray KT, Yu C, Byrne JG, Greelish JP, Petracek MR, Hoff SJ, Ball SK, Brown NJ, Pretorius M. Milrinone use is associated with postoperative atrial fibrillation after cardiac surgery. Circulation. 2008;118:1619–25.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Flynn JT. Management of hypertension in the young: role of antihypertensive medications. J Cardiovasc Pharmacol. 2011;58:111–20.

    Article  PubMed  CAS  Google Scholar 

  • Flynn JT, Bradford MC, Harvey EM. Intravenous hydralazine in hospitalized children and adolescents with hypertension. J Pediatr. 2016;168:88–92.

    Article  PubMed  CAS  Google Scholar 

  • Franz D, Contreras F, Gonzalez H, Prado C, Elgueta D, Figueroa C, Pacheco R. Dopamine receptors D3 and D5 regulate CD4(+)T-cell activation and differentiation by modulating ERK activation and cAMP production. J Neuroimmunol. 2015;284:18–29.

    Article  PubMed  CAS  Google Scholar 

  • Friederich JA, Butterworth JF. Sodium nitroprusside: twenty years and counting. Anesth Analg. 1995;81:152–62.

    PubMed  CAS  Google Scholar 

  • Friesen RH, Williams GD. Anesthetic management of children with pulmonary arterial hypertension. Paediatr Anaesth. 2008;18:208–16.

    Article  PubMed  Google Scholar 

  • Fuchs C, Ertmer C, Rehberg S. Effects of vasodilators on haemodynamic coherence. Best Pract Res Clin Anaesthesiol. 2016;30:479–89.

    Article  PubMed  Google Scholar 

  • Galante D. Intraoperative management of pulmonary arterial hypertension in infants and children—corrected and republished article. Curr Opin Anaesthesiol. 2011;24:468–71.

    Article  PubMed  Google Scholar 

  • Gamidov SI, Ovchinnikov RI, Popova AY, Izhbaev SK. Phosphodiesterase type 5 inhibitors in the treatment of erectile dysfunction: past, present and future. Urologiia. 2017;1:103–7.

    Article  Google Scholar 

  • Gao Y, Raj JU. Regulation of the pulmonary circulation in the fetus and newborn. Physiol Rev. 2010;90:1291–335.

    Article  PubMed  CAS  Google Scholar 

  • Garcia-Rivas G, Jerjes-Sanchez C, Rodriguez D, Garcia-Pelaez J, Trevino V. A systematic review of genetic mutations in pulmonary arterial hypertension. BMC Med Genet. 2017;18:82.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gaudino M, Antoniades C, Benedetto U, Deb S, Di Franco A, Di Giammarco G, Fremes S, Glineur D, Grau J, He GW, Marinelli D, Ohmes LB, Patrono C, Puskas J, Tranbaugh R, Girardi LN, Taggart DP. Mechanisms, consequences, and prevention of coronary graft failure. Circulation. 2017;136:1749–64.

    Article  PubMed  Google Scholar 

  • Gavra P, Laflamme M, Denault AY, Theoret Y, Perrault LP, Varin F. Use of nebulized milrinone in cardiac surgery; comparison of vibrating mesh and simple jet nebulizers. Pulm Pharmacol Ther. 2017;46:20–9.

    Article  PubMed  CAS  Google Scholar 

  • Giesinger RE, More K, Odame J, Jain A, Jankov RP, McNamara PJ. Controversies in the identification and management of acute pulmonary hypertension in preterm neonates. Pediatr Res. 2017;82(6):901–14.

    Article  PubMed  Google Scholar 

  • Giglia TM, Witmer C, Procaccini DE, Byrnes JW. Pediatric cardiac intensive care society 2014 consensus statement: pharmacotherapies in cardiac critical care anticoagulation and thrombolysis. Pediatr Crit Care Med. 2016;17:S77–88.

    Article  PubMed  Google Scholar 

  • Gist KM, Goldstein SL, Joy MS, Vinks AA. Milrinone dosing issues in critically ill children with kidney injury: a review. J Cardiovasc Pharmacol. 2016;67:175–81.

    Article  PubMed  CAS  Google Scholar 

  • Glund S, Moschetti V, Norris S, Stangier J, Schmohl M, van Ryn J, Lang B, Ramael S, Reilly P. A randomised study in healthy volunteers to investigate the safety, tolerability and pharmacokinetics of idarucizumab, a specific antidote to dabigatran. Thromb Haemost. 2015;113:943–51.

    Article  PubMed  Google Scholar 

  • Gordon NK, Gordon R. The organelle of differentiation in embryos: the cell state splitter. Theor Biol Med Model. 2016;13:35.

    Article  Google Scholar 

  • Green JB, Hart B, Cornett EM, Kaye AD, Salehi A, Fox CJ. Pulmonary vasodilators and anesthesia considerations. Anesthesiol Clin. 2017;35:221–32.

    Article  PubMed  Google Scholar 

  • Gresele P, Momi S, Falcinelli E. Anti-platelet therapy: phosphodiesterase inhibitors. Br J Clin Pharmacol. 2011;72:634–46.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Griffin MR. Epidemiology of nonsteroidal anti-inflammatory drug-associated gastrointestinal injury. Am J Med. 1998;104:23S–9S; discussion 41S–42S.

    Article  PubMed  CAS  Google Scholar 

  • Hamzaoui O, Scheeren TWL, Teboul JL. Norepinephrine in septic shock: when and how much? Curr Opin Crit Care. 2017;23:342–7.

    Article  PubMed  Google Scholar 

  • Hansmann G, Apitz C, Abdul-Khaliq H, Alastalo TP, Beerbaum P, Bonnet D, Dubowy KO, Gorenflo M, Hager A, Hilgendorff A, Kaestner M, Koestenberger M, Koskenvuo JW, Kozlik-Feldmann R, Kuehne T, Lammers AE, Latus H, Michel-Behnke I, Miera O, Moledina S, Muthurangu V, Pattathu J, Schranz D, Warnecke G, Zartner P. Executive summary. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric pulmonary vascular disease network, endorsed by ISHLT and DGPK. Heart. 2016;102(Suppl 2):ii86–ii100.

    Article  PubMed  CAS  Google Scholar 

  • Hari P, Sinha A. Hypertensive emergencies in children. Indian J Pediatr. 2011;78:569–75.

    Article  PubMed  Google Scholar 

  • Herrera AJ, Espinosa-Oliva AM, Carrillo-Jimenez A, Oliva-Martin MJ, Garcia-Revilla J, Garcia-Quintanilla A, de Pablos RM, Venero JL. Relevance of chronic stress and the two faces of microglia in Parkinson’s disease. Front Cell Neurosci. 2015;9:312.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Herzog-Niescery J, Seipp HM, Weber TP, Bellgardt M. Inhaled anesthetic agent sedation in the ICU and trace gas concentrations: a review. J Clin Monit Comput. 2017. https://doi.org/10.1007/s10877-017-0055-6.

  • Holmes CL. Vasoactive drugs in the intensive care unit. Curr Opin Crit Care. 2005;11:413–7.

    Article  PubMed  Google Scholar 

  • Holmes CL, Landry DW, Granton JT. Science review: vasopressin and the cardiovascular system part 1—receptor physiology. Crit Care. 2003;7:427–34.

    Article  PubMed  PubMed Central  Google Scholar 

  • Holmes CL, Landry DW, Granton JT. Science review: vasopressin and the cardiovascular system part 2—clinical physiology. Crit Care. 2004;8:15–23.

    Article  PubMed  Google Scholar 

  • Hottinger DG, Beebe DS, Kozhimannil T, Prielipp RC, Belani KG. Sodium nitroprusside in 2014: a clinical concepts review. J Anaesthesiol Clin Pharmacol. 2014;30:462–71.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hummel J, Rucker G, Stiller B. Prophylactic levosimendan for the prevention of low cardiac output syndrome and mortality in paediatric patients undergoing surgery for congenital heart disease. Cochrane Database Syst Rev. 2017a;8:Cd011312.

    PubMed  Google Scholar 

  • Hummel J, Rucker G, Stiller B. Prophylactic levosimendan for the prevention of low cardiac output syndrome and mortality in paediatric patients undergoing surgery for congenital heart disease. Cochrane Database Syst Rev. 2017b;3:Cd011312.

    PubMed  Google Scholar 

  • Iarussi T, Marolla A, Pardolesi A, Patea RL, Camplese P, Sacco R. Sternectomy and sternum reconstruction for infection after cardiac surgery. Ann Thorac Surg. 2008;86:1680–1.

    Article  PubMed  Google Scholar 

  • Janssen PWA, Claassens DMF, Willemsen LM, Bergmeijer TO, Klein P, Ten Berg JM. Perioperative management of antiplatelet treatment in patients undergoing isolated coronary artery bypass grafting in Dutch cardiothoracic centres. Neth Hear J. 2017;25(9):482–9.

    Article  CAS  Google Scholar 

  • Jentzer JC, Coons JC, Link CB, Schmidhofer M. Pharmacotherapy update on the use of vasopressors and inotropes in the intensive care unit. J Cardiovasc Pharmacol Ther. 2015;20:249–60.

    Article  PubMed  CAS  Google Scholar 

  • Jentzer JC, Mathier MA. Pulmonary hypertension in the intensive care unit. J Intensive Care Med. 2016;31(6):369–85.

    Article  PubMed  Google Scholar 

  • Jiang M, Karasawa T, Steyger PS. Aminoglycoside-induced cochleotoxicity: a review. Front Cell Neurosci. 2017;11:308.

    Article  PubMed  PubMed Central  Google Scholar 

  • Jortveit J, Leirgul E, Eskedal L, Greve G, Fomina T, Dohlen G, Tell GS, Birkeland S, Oyen N, Holmstrom H. Mortality and complications in 3495 children with isolated ventricular septal defects. Arch Dis Child. 2016;101(9):808–13.

    Article  PubMed  Google Scholar 

  • Kee VR. Hemodynamic pharmacology of intravenous vasopressors. Crit Care Nurse. 2003;23:79–82.

    PubMed  Google Scholar 

  • Kelly LE, Ohlsson A, Shah PS. Sildenafil for pulmonary hypertension in neonates. Cochrane Database Syst Rev. 2017;8:Cd005494.

    PubMed  Google Scholar 

  • Khan SU, Winnicka L, Saleem MA, Rahman H, Rehman N. Amiodarone, lidocaine, magnesium or placebo in shock refractory ventricular arrhythmia: a Bayesian network meta-analysis. Heart Lung. 2017;46:417–24.

    Article  PubMed  Google Scholar 

  • Kim JS, McSweeney J, Lee J, Ivy D. Pediatric cardiac intensive care society 2014 consensus statement: pharmacotherapies in cardiac critical care pulmonary hypertension. Pediatr Crit Care Med. 2016;17:S89–s100.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kleinman ME, Chameides L, Schexnayder SM, Samson RA, Hazinski MF, Atkins DL, Berg MD, de Caen AR, Fink EL, Freid EB, Hickey RW, Marino BS, Nadkarni VM, Proctor LT, Qureshi FA, Sartorelli K, Topjian A, van der Jagt EW, Zaritsky AL. Part 14: pediatric advanced life support: 2010 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2010;122:S876–908.

    Article  PubMed  Google Scholar 

  • Klinger JR, Kadowitz PJ. The nitric oxide pathway in pulmonary vascular disease. Am J Cardiol. 2017;120:S71–s79.

    Article  PubMed  CAS  Google Scholar 

  • Klugman D, Goswami ES, Berger JT. Pediatric cardiac intensive care society 2014 consensus statement: pharmacotherapies in cardiac critical care antihypertensives. Pediatr Crit Care Med. 2016;17:S101–8.

    Article  PubMed  Google Scholar 

  • Knight WE, Yan C. Cardiac cyclic nucleotide phosphodiesterases: function, regulation, and therapeutic prospects. Horm Metab Res. 2012;44:766–75.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kniotek M, Boguska A. Sildenafil can affect innate and adaptive immune system in both experimental animals and patients. J Immunol Res. 2017;2017:4541958.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kozlik-Feldmann R, Hansmann G, Bonnet D, Schranz D, Apitz C, Michel-Behnke I. Pulmonary hypertension in children with congenital heart disease (PAH-CHD, PPHVD-CHD). Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK. Heart. 2016;102(Suppl 2):ii42–8.

    Article  PubMed  CAS  Google Scholar 

  • Kushwah S, Kumar A, Sahana KS. Levosimendan. A promising future drug for refractory cardiac failure in children? Indian Heart J. 2016;68(Suppl 1):S57–60.

    Article  PubMed  Google Scholar 

  • Lai MY, Chu SM, Lakshminrusimha S, Lin HC. Beyond the inhaled nitric oxide in persistent pulmonary hypertension of the newborn. Pediatr Neonatol. 2017. https://doi.org/10.1016/j.pedneo.2016.09.011.

  • Lakshminrusimha S, Mathew B, Leach CL. Pharmacologic strategies in neonatal pulmonary hypertension other than nitric oxide. Semin Perinatol. 2016;40:160–73.

    Article  PubMed  PubMed Central  Google Scholar 

  • Landoni G, Biondi-Zoccai G, Greco M, Greco T, Bignami E, Morelli A, Guarracino F, Zangrillo A. Effects of levosimendan on mortality and hospitalization. A meta-analysis of randomized controlled studies. Crit Care Med. 2012;40:634–46.

    Article  PubMed  CAS  Google Scholar 

  • Langford RM, Mehta V. Selective cyclooxygenase inhibition: its role in pain and anaesthesia. Biomed Pharmacother. 2006;60:323–8.

    Article  PubMed  CAS  Google Scholar 

  • Latorre R, Castillo K, Carrasquel-Ursulaez W, Sepulveda RV, Gonzalez-Nilo F, Gonzalez C, Alvarez O. Molecular determinants of BK channel functional diversity and functioning. Physiol Rev. 2017;97:39–87.

    Article  PubMed  Google Scholar 

  • Latus H, Delhaas T, Schranz D, Apitz C. Treatment of pulmonary arterial hypertension in children. Nat Rev Cardiol. 2015;12:244–54.

    Article  PubMed  CAS  Google Scholar 

  • Latus H, Kuehne T, Beerbaum P, Apitz C, Hansmann G, Muthurangu V, Moledina S. Cardiac MR and CT imaging in children with suspected or confirmed pulmonary hypertension/pulmonary hypertensive vascular disease. Expert consensus statement on the diagnosis and treatment of paediatric pulmonary hypertension. The European Paediatric Pulmonary Vascular Disease Network, endorsed by ISHLT and DGPK. Heart. 2016;102(Suppl 2):ii30–5.

    Article  PubMed  CAS  Google Scholar 

  • Lechner E, Hofer A, Leitner-Peneder G, Freynschlag R, Mair R, Weinzettel R, Rehak P, Gombotz H. Levosimendan versus milrinone in neonates and infants after corrective open-heart surgery: a pilot study. Pediatr Crit Care Med. 2012;13:542–8.

    Article  PubMed  Google Scholar 

  • Leone M, Martin C. Role of terlipressin in the treatment of infants and neonates with catecholamine-resistant septic shock. Best Pract Res Clin Anaesthesiol. 2008;22:323–33.

    Article  PubMed  CAS  Google Scholar 

  • Lepelletier D, Perron S, Bizouarn P, Caillon J, Drugeon H, Michaud JL, Duveau D. Surgical-site infection after cardiac surgery: incidence, microbiology, and risk factors. Infect Control Hosp Epidemiol. 2005;26:466–72.

    Article  PubMed  Google Scholar 

  • Levite M. Dopamine and T cells: dopamine receptors and potent effects on T cells, dopamine production in T cells, and abnormalities in the dopaminergic system in T cells in autoimmune, neurological and psychiatric diseases. Acta Physiol (Oxford). 2016;216:42–89.

    Article  CAS  Google Scholar 

  • Li H, Kim HW, Shin SE, Seo MS, An JR, Ha KS, Han ET, Hong SH, Firth AL, Choi IW, Han IY, Lee DS, Yim MJ, Park WS. The vasorelaxant effect of mitiglinide via activation of voltage-dependent K+ channels and SERCA pump in aortic smooth muscle. Life Sci. 2017a;188:1–9.

    Article  PubMed  CAS  Google Scholar 

  • Li J, Tang B, Zhang W, Wang C, Yang S, Zhang B, Gao X. Relationship and mechanism of Kv2.1 expression to ADH secretion in rats with heart failure. Am J Transl Res. 2017b;9:3687–95.

    PubMed  PubMed Central  Google Scholar 

  • Li MX, Hwang PM. Structure and function of cardiac troponin C (TNNC1): implications for heart failure, cardiomyopathies, and troponin modulating drugs. Gene. 2015;571:153–66.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Liu C, Chen J, Gao Y, Deng B, Liu K. Endothelin receptor antagonists for pulmonary arterial hypertension. Cochrane Database Syst Rev. 2013;2:Cd004434.

    Google Scholar 

  • Lomis N, Gaudreault F, Malhotra M, Westfall S, Shum-Tim D, Prakash S. A novel milrinone nanoformulation for use in cardiovascular diseases: preparation and in vitro characterization. Mol Pharm. 2017;

    Google Scholar 

  • Lucas SS, Nasr VG, Ng AJ, Joe C, Bond M, DiNardo JA. Pediatric cardiac intensive care society 2014 consensus statement: pharmacotherapies in cardiac critical care: sedation, analgesia and muscle relaxant. Pediatr Crit Care Med. 2016;17:S3–s15.

    Article  PubMed  Google Scholar 

  • Maconochie IK, de Caen AR, Aickin R, Atkins DL, Biarent D, Guerguerian AM, Kleinman ME, Kloeck DA, Meaney PA, Nadkarni VM, Ng KC, Nuthall G, Reis AG, Shimizu N, Tibballs J, Pintos RV. Part 6: pediatric basic life support and pediatric advanced life support: 2015 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Resuscitation. 2015;95:e147–68.

    Article  PubMed  Google Scholar 

  • Majure DT, Greco T, Greco M, Ponschab M, Biondi-Zoccai G, Zangrillo A, Landoni G. Meta-analysis of randomized trials of effect of milrinone on mortality in cardiac surgery: an update. J Cardiothorac Vasc Anesth. 2013;27:220–9.

    Article  PubMed  CAS  Google Scholar 

  • Maldifassi MC, Baur R, Sigel E. Functional sites involved in modulation of the GABA receptor channel by the intravenous anesthetics propofol, etomidate and pentobarbital. Neuropharmacology. 2016;105:207–14.

    Article  PubMed  CAS  Google Scholar 

  • Marcotti W, Johnson SL, Kros CJ. A transiently expressed SK current sustains and modulates action potential activity in immature mouse inner hair cells. J Physiol. 2004;560:691–708.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Marionneau C, Abriel H. Regulation of the cardiac Na channel Na1.5 by post-translational modifications. J Mol Cell Cardiol. 2015;82:36–47.

    Article  PubMed  CAS  Google Scholar 

  • Maslov MY, Wei AE, Pezone MJ, Edelman ER, Lovich MA. Vascular dilation, tachycardia, and increased inotropy occur sequentially with increasing epinephrine dose rate, plasma and myocardial concentrations, and cAMP. Heart Lung Circ. 2015;24:912–8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Mauri L, Kereiakes DJ, Yeh RW, Driscoll-Shempp P, Cutlip DE, Steg PG, Normand SL, Braunwald E, Wiviott SD, Cohen DJ, Holmes DR Jr, Krucoff MW, Hermiller J, Dauerman HL, Simon DI, Kandzari DE, Garratt KN, Lee DP, Pow TK, Ver Lee P, Rinaldi MJ, Massaro JM. Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents. N Engl J Med. 2014;371:2155–66.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • McCammond AN, Axelrod DM, Bailly DK, Ramsey EZ, Costello JM. Pediatric cardiac intensive care society 2014 consensus statement: pharmacotherapies in cardiac critical care fluid management. Pediatr Crit Care Med. 2016;17:S35–48.

    Article  PubMed  Google Scholar 

  • McMahon TJ, Bryan NS. Biomarkers in pulmonary vascular disease: gauging response to therapy. Am J Cardiol. 2017;120:S89–s95.

    Article  PubMed  CAS  Google Scholar 

  • Mebazaa A, Nieminen MS, Packer M, Cohen-Solal A, Kleber FX, Pocock SJ, Thakkar R, Padley RJ, Poder P, Kivikko M. Levosimendan vs dobutamine for patients with acute decompensated heart failure: the SURVIVE randomized trial. JAMA. 2007;297:1883–91.

    Article  PubMed  CAS  Google Scholar 

  • Mehta PA, Cunningham CK, Colella CB, Alferis G, Weiner LB. Risk factors for sternal wound and other infections in pediatric cardiac surgery patients. Pediatr Infect Dis J. 2000;19:1000–4.

    Article  PubMed  CAS  Google Scholar 

  • Mehta S, Granton J, Gordon AC, Cook DJ, Lapinsky S, Newton G, Bandayrel K, Little A, Siau C, Ayers D, Singer J, Lee TC, Walley KR, Storms M, Cooper DJ, Holmes CL, Hebert P, Presneill J, Russell JA. Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine. Crit Care. 2013;17:R117.

    Article  PubMed  PubMed Central  Google Scholar 

  • Meyer S, Gortner L, McGuire W, Baghai A, Gottschling S. Vasopressin in catecholamine-refractory shock in children. Anaesthesia. 2008;63:228–34.

    Article  PubMed  CAS  Google Scholar 

  • Meyer S, McGuire W, Gottschling S, Mohammed Shamdeen G, Gortner L. The role of vasopressin and terlipressin in catecholamine-resistant shock and cardio-circulatory arrest in children: review of the literature. Wien Med Wochenschr. 2011;161:192–203.

    Article  PubMed  Google Scholar 

  • Minton J, Sidebotham DA. Hyperlactatemia and cardiac surgery. J Extra Corpor Technol. 2017;49:7–15.

    PubMed  PubMed Central  Google Scholar 

  • Mirhosseini SM, Sanjari Moghaddam A, Tahmaseb Pour P, Dabbagh A. Refractory vasoplegic syndrome in an adult patient with infective endocarditis: a case report and literature review. J Tehran Heart Cent. 2017;12:27–31.

    PubMed  PubMed Central  Google Scholar 

  • Moffett BS, Price JF. Evaluation of sodium nitroprusside toxicity in pediatric cardiac surgical patients. Ann Pharmacother. 2008;42:1600–4.

    Article  PubMed  CAS  Google Scholar 

  • Moffett BS, Salvin JW, Kim JJ. Pediatric cardiac intensive care society 2014 consensus statement: pharmacotherapies in cardiac critical care antiarrhythmics. Pediatr Crit Care Med. 2016;17:S49–58.

    Article  PubMed  Google Scholar 

  • Mossad E, Motta P, Sehmbey K, Toscana D. The hemodynamic effects of phenoxybenzamine in neonates, infants, and children. J Clin Anesth. 2008;20:94–8.

    Article  PubMed  CAS  Google Scholar 

  • Mossad EB. Pro: intraoperative use of nitric oxide for treatment of pulmonary hypertension in patients with congenital heart disease is effective. J Cardiothorac Vasc Anesth. 2001;15:259–62.

    Article  PubMed  CAS  Google Scholar 

  • Mossad EB, Motta P, Rossano J, Hale B, Morales DL. Perioperative management of pediatric patients on mechanical cardiac support. Paediatr Anaesth. 2011;21:585–93.

    Article  PubMed  Google Scholar 

  • Motta P, Mossad E, Toscana D, Zestos M, Mee R. Comparison of phenoxybenzamine to sodium nitroprusside in infants undergoing surgery. J Cardiothorac Vasc Anesth. 2005;19:54–9.

    Article  PubMed  CAS  Google Scholar 

  • Motyl KJ, Beauchemin M, Barlow D, Le PT, Nagano K, Treyball A, Contractor A, Baron R, Rosen CJ, Houseknecht KL. A novel role for dopamine signaling in the pathogenesis of bone loss from the atypical antipsychotic drug risperidone in female mice. Bone. 2017;103:168–76.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Nanayakkara S, Bergin P, Mak V, Crannitch K, Kaye DM. Extended release oral milrinone as an adjunct to heart failure therapy. Intern Med J. 2017;47:973–4.

    Article  PubMed  Google Scholar 

  • Nateghian A, Taylor G, Robinson JL. Risk factors for surgical site infections following open-heart surgery in a Canadian pediatric population. Am J Infect Control. 2004;32:397–401.

    Article  PubMed  Google Scholar 

  • Nazir SA, Khan JN, Mahmoud IZ, Greenwood JP, Blackman DJ, Kunadian V, Been M, Abrams KR, Wilcox R, Adgey AAJ, McCann GP, Gershlick AH. Efficacy and Mechanism Evaluation. In: The REFLO-STEMI (REperfusion Facilitated by LOcal adjunctive therapy in ST-Elevation Myocardial Infarction) trial: a randomised controlled trial comparing intracoronary administration of adenosine or sodium nitroprusside with control for attenuation of microvascular obstruction during primary percutaneous coronary intervention. Southampton (UK): NIHR Journals Library Copyright (c) Queen’s Printer and Controller of HMSO 2016. This work was produced by Nazir et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK; 2016.

    Article  Google Scholar 

  • Ng KT, Yap JLL. Continuous infusion vs. intermittent bolus injection of furosemide in acute decompensated heart failure: systematic review and meta-analysis of randomised controlled trials. Anaesthesia. 2018;73(2):238–47.

    Article  PubMed  CAS  Google Scholar 

  • Nieminen MS, Fruhwald S, Heunks LM, Suominen PK, Gordon AC, Kivikko M, Pollesello P. Levosimendan: current data, clinical use and future development. Heart Lung Vess. 2013;5:227–45.

    CAS  Google Scholar 

  • Noori S, Seri I. Neonatal blood pressure support: the use of inotropes, lusitropes, and other vasopressor agents. Clin Perinatol. 2012;39:221–38.

    Article  PubMed  Google Scholar 

  • O’Brien A, Clapp L, Singer M. Terlipressin for norepinephrine-resistant septic shock. Lancet. 2002;359:1209–10.

    Article  PubMed  Google Scholar 

  • Ogawa R, Stachnik JM, Echizen H. Clinical pharmacokinetics of drugs in patients with heart failure: an update (part 2, drugs administered orally). Clin Pharmacokinet. 2014;53:1083–114.

    Article  PubMed  CAS  Google Scholar 

  • Ostrye J, Hailpern SM, Jones J, Egan B, Chessman K, Shatat IF. The efficacy and safety of intravenous hydralazine for the treatment of hypertension in the hospitalized child. Pediatr Nephrol. 2014;29:1403–9.

    Article  PubMed  Google Scholar 

  • Pacheco R, Contreras F, Zouali M. The dopaminergic system in autoimmune diseases. Front Immunol. 2014;5:117.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Panchal AR, Satyanarayan A, Bahadir JD, Hays D, Mosier J. Efficacy of bolus-dose phenylephrine for peri-intubation hypotension. J Emerg Med. 2015;49:488–94.

    Article  PubMed  Google Scholar 

  • Papp Z, Edes I, Fruhwald S, De Hert SG, Salmenpera M, Leppikangas H, Mebazaa A, Landoni G, Grossini E, Caimmi P, Morelli A, Guarracino F, Schwinger RH, Meyer S, Algotsson L, Wikstrom BG, Jorgensen K, Filippatos G, Parissis JT, Gonzalez MJ, Parkhomenko A, Yilmaz MB, Kivikko M, Pollesello P, Follath F. Levosimendan: molecular mechanisms and clinical implications: consensus of experts on the mechanisms of action of levosimendan. Int J Cardiol. 2012;159:82–7.

    Article  PubMed  Google Scholar 

  • Parham WA, Mehdirad AA, Biermann KM, Fredman CS. Hyperkalemia revisited. Tex Heart Inst J. 2006;33:40–7.

    PubMed  PubMed Central  Google Scholar 

  • Parthenakis F, Maragkoudakis S, Marketou M, Patrianakos A, Zacharis E, Vardas P. Myocardial inotropic reserve: an old twist that constitutes a reliable index in the modern era of heart failure. Am J Cardiovasc Drugs. 2016;57:311–4.

    Google Scholar 

  • Perez KM, Laughon M. Sildenafil in term and premature infants: a systematic review. Clin Ther. 2015;37:2598.e2591–607.e2591.

    Article  CAS  Google Scholar 

  • Pinoli M, Marino F, Cosentino M. Dopaminergic regulation of innate immunity: a review. J NeuroImmune Pharmacol. 2017;12(4):602–23.

    Article  PubMed  Google Scholar 

  • Pollack CV Jr, Reilly PA, Eikelboom J, Glund S, Verhamme P, Bernstein RA, Dubiel R, Huisman MV, Hylek EM, Kamphuisen PW, Kreuzer J, Levy JH, Sellke FW, Stangier J, Steiner T, Wang B, Kam CW, Weitz JI. Idarucizumab for dabigatran reversal. N Engl J Med. 2015;373:511–20.

    Article  PubMed  CAS  Google Scholar 

  • Poor HD, Ventetuolo CE. Pulmonary hypertension in the intensive care unit. Prog Cardiovasc Dis. 2012;55:187–98.

    Article  PubMed  Google Scholar 

  • Prado C, Bernales S, Pacheco R. Modulation of T-cell mediated immunity by dopamine receptor d5. Endocr Metab Immune Disord Drug Targets. 2013;13:184–94.

    Article  PubMed  CAS  Google Scholar 

  • Pritts CD, Pearl RG. Anesthesia for patients with pulmonary hypertension. Curr Opin Anaesthesiol. 2010;23:411–6.

    Article  PubMed  Google Scholar 

  • Reveiz L, Guerrero-Lozano R, Camacho A, Yara L, Mosquera PA. Stress ulcer, gastritis, and gastrointestinal bleeding prophylaxis in critically ill pediatric patients: a systematic review. Pediatr Crit Care Med. 2010;11:124–32.

    Article  PubMed  Google Scholar 

  • Rizza A, Bignami E, Belletti A, Polito A, Ricci Z, Isgro G, Locatelli A, Cogo P. Vasoactive drugs and hemodynamic monitoring in pediatric cardiac intensive care: an italian survey. World J Pediatr Congenit Heart Surg. 2016;7:25–31.

    Article  PubMed  Google Scholar 

  • Roeleveld PP, Zwijsen EG. Treatment strategies for paradoxical hypertension following surgical correction of coarctation of the aorta in children. World J Pediatr Congenit Heart Surg. 2017;8:321–31.

    Article  PubMed  PubMed Central  Google Scholar 

  • Romantsik O, Calevo MG, Norman E, Bruschettini M. Clonidine for sedation and analgesia for neonates receiving mechanical ventilation. Cochrane Database Syst Rev. 2017;5:Cd012468.

    PubMed  Google Scholar 

  • Rossano JW, Cabrera AG, Jefferies JL, Naim MP, Humlicek T. Pediatric cardiac intensive care society 2014 consensus statement: pharmacotherapies in cardiac critical care chronic heart failure. Pediatr Crit Care Med. 2016;17:S20–34.

    Article  PubMed  Google Scholar 

  • Russell JA. Bench-to-bedside review: vasopressin in the management of septic shock. Crit Care. 2011;15:226.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ryu HG, Jung CW, Lee HC, Cho YJ. Epinephrine and phenylephrine pretreatments for preventing postreperfusion syndrome during adult liver transplantation. Liver Transpl. 2012;18:1430–9.

    Article  PubMed  Google Scholar 

  • Salem S, Askandar S, Khouzam RN. Aspirin monotherapy vs. dual antiplatelet therapy in diabetic patients following coronary artery bypass graft (CABG): where do we stand? Ann Transl Med. 2017;5:213.

    Article  PubMed  PubMed Central  Google Scholar 

  • Scanzano A, Cosentino M. Adrenergic regulation of innate immunity: a review. Front Pharmacol. 2015;6:171.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Schouten ES, van de Pol AC, Schouten AN, Turner NM, Jansen NJ, Bollen CW. The effect of aprotinin, tranexamic acid, and aminocaproic acid on blood loss and use of blood products in major pediatric surgery: a meta-analysis. Pediatr Crit Care Med. 2009;10:182–90.

    Article  PubMed  Google Scholar 

  • Shah PS, Ohlsson A. Sildenafil for pulmonary hypertension in neonates. Cochrane Database Syst Rev. 2011;8:Cd005494.

    Google Scholar 

  • Shang G, Yang X, Song D, Ti Y, Shang Y, Wang Z, Tang M, Zhang Y, Zhang W, Zhong M. Effects of levosimendan on patients with heart failure complicating acute coronary syndrome: a meta-analysis of randomized controlled trials. Am J Cardiovasc Drugs. 2017;17(6):453–63.

    Article  PubMed  CAS  Google Scholar 

  • Shao H, Li CS. Epinephrine in out-of-hospital cardiac arrest: helpful or harmful? Chin Med J. 2017;130:2112–6.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sharawy N. Vasoplegia in septic shock: do we really fight the right enemy? J Crit Care. 2014;29:83–7.

    Article  PubMed  CAS  Google Scholar 

  • Silvetti S, Silvani P, Azzolini ML, Dossi R, Landoni G, Zangrillo A. A systematic review on levosimendan in paediatric patients. Curr Vasc Pharmacol. 2015;13:128–33.

    Article  PubMed  CAS  Google Scholar 

  • Simons FE, Sampson HA. Anaphylaxis: unique aspects of clinical diagnosis and management in infants (birth to age 2 years). J Allergy Clin Immunol. 2015;135:1125–31.

    Article  PubMed  Google Scholar 

  • Singh VK, Sharma R, Agrawal A, Varma A. Vasopressin in the pediatric cardiac intensive care unit: myth or reality. Ann Pediatr Cardiol. 2009;2:65–73.

    Article  PubMed  PubMed Central  Google Scholar 

  • Smith KA, Ayon RJ, Tang H, Makino A, Yuan JX. Calcium-sensing receptor regulates cytosolic [Ca 2+] and plays a major role in the development of pulmonary hypertension. Front Physiol. 2016;7:517.

    Article  PubMed  PubMed Central  Google Scholar 

  • Stahl W, Bracht H, Radermacher P, Thomas J. Year in review 2009: critical care—shock. Crit Care. 2010;14:239.

    Article  PubMed  PubMed Central  Google Scholar 

  • Stratton L, Berlin DA, Arbo JE. Vasopressors and inotropes in sepsis. Emerg Med Clin North Am. 2017;35:75–91.

    Article  PubMed  Google Scholar 

  • Strobel AM, Lu le N. The critically ill infant with congenital heart disease. Emerg Med Clin North Am. 2015;33:501–18.

    Article  PubMed  Google Scholar 

  • Thomas C, Svehla L, Moffett BS. Sodium-nitroprusside-induced cyanide toxicity in pediatric patients. Expert Opin Drug Saf. 2009;8:599–602.

    Article  PubMed  CAS  Google Scholar 

  • Touchan J, Guglin M. Temporary mechanical circulatory support for cardiogenic shock. Curr Treat Options Cardiovasc Med. 2017;19:77.

    Article  PubMed  Google Scholar 

  • Tran KC, Leung AA, Tang KL, Quan H, Khan NA. Efficacy of calcium channel blockers on major cardiovascular outcomes for the treatment of hypertension in asian populations: a meta-analysis. Can J Cardiol. 2017;33:635–43.

    Article  PubMed  Google Scholar 

  • Trappe HJ, Brandts B, Weismueller P. Arrhythmias in the intensive care patient. Curr Opin Crit Care. 2003;9:345–55.

    Article  PubMed  Google Scholar 

  • Tremblay JA, Beaubien-Souligny W, Elmi-Sarabi M, Desjardins G, Denault AY. Point-of-care ultrasonography to assess portal vein pulsatility and the effect of inhaled milrinone and epoprostenol in severe right ventricular failure: a report of 2 cases. A A Case Rep. 2017;9:219–23.

    Article  PubMed  Google Scholar 

  • Twite MD, Friesen RH. The anesthetic management of children with pulmonary hypertension in the cardiac catheterization laboratory. Anesthesiol Clin. 2014;32:157–73.

    Article  PubMed  Google Scholar 

  • Unegbu C, Noje C, Coulson JD, Segal JB, Romer L. Pulmonary hypertension therapy and a systematic review of efficacy and safety of PDE-5 inhibitors. Pediatrics. 2017;139(3):e20161450.

    Article  PubMed  Google Scholar 

  • Varon J, Marik PE. Clinical review: the management of hypertensive crises. Crit Care. 2003;7:374–84.

    Article  PubMed  PubMed Central  Google Scholar 

  • Vasu TS, Cavallazzi R, Hirani A, Kaplan G, Leiby B, Marik PE. Norepinephrine or dopamine for septic shock: systematic review of randomized clinical trials. J Intensive Care Med. 2012;27:172–8.

    Article  PubMed  Google Scholar 

  • Vaughan Williams EM. Relevance of cellular to clinical electrophysiology in interpreting antiarrhythmic drug action. Am J Cardiol. 1989;64:5j–9j.

    Article  PubMed  CAS  Google Scholar 

  • Vaughan Williams EM. The relevance of cellular to clinical electrophysiology in classifying antiarrhythmic actions. J Cardiovasc Pharmacol. 1992;20(Suppl 2):S1–7.

    Article  PubMed  Google Scholar 

  • Ventetuolo CE, Klinger JR. Management of acute right ventricular failure in the intensive care unit. Ann Am Thorac Soc. 2014;11:811–22.

    Article  PubMed  PubMed Central  Google Scholar 

  • Verghese ST, Hannallah RS. Acute pain management in children. J Pain Res. 2010;3:105–23.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Vijarnsorn C, Winijkul G, Laohaprasitiporn D, Chungsomprasong P, Chanthong P, Durongpisitkul K, Soonswang J, Nana A, Subtaweesin T, Sriyoschati S, Pooliam J. Postoperative fever and major infections after pediatric cardiac surgery. J Med Assoc Thail. 2012;95:761–70.

    Google Scholar 

  • Vorhies EE, Ivy DD. Drug treatment of pulmonary hypertension in children. Paediatr Drugs. 2014;16:43–65.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wang A. Review of vorapaxar for the prevention of atherothrombotic events. Expert Opin Pharmacother. 2015;16:2509–22.

    Article  PubMed  CAS  Google Scholar 

  • Wang RC, Jiang FM, Zheng QL, Li CT, Peng XY, He CY, Luo J, Liang ZA. Efficacy and safety of sildenafil treatment in pulmonary arterial hypertension: a systematic review. Respir Med. 2014;108:531–7.

    Article  PubMed  Google Scholar 

  • Watt K, Li JS, Benjamin DK Jr, Cohen-Wolkowiez M. Pediatric cardiovascular drug dosing in critically ill children and extracorporeal membrane oxygenation. J Cardiovasc Pharmacol. 2011;58:126–32.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wolf CM, Berul CI. Molecular mechanisms of inherited arrhythmias. Curr Genomics. 2008;9:160–8.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Xue H, Lu Z, Tang WL, Pang LW, Wang GM, Wong GW, Wright JM. First-line drugs inhibiting the renin angiotensin system versus other first-line antihypertensive drug classes for hypertension. Cochrane Database Syst Rev. 2015;1:Cd008170.

    PubMed  Google Scholar 

  • Yandrapalli S, Tariq S, Aronow WS. Advances in chemical pharmacotherapy for managing acute decompensated heart failure. Am J Cardiovasc Drugs. 2017;18:471–85.

    Google Scholar 

  • Yerokun BA, Williams JB, Gaca J, Smith PK, Roe MT. Indications, algorithms, and outcomes for coronary artery bypass surgery in patients with acute coronary syndromes. Coron Artery Dis. 2016;27:319–26.

    Article  PubMed  PubMed Central  Google Scholar 

  • Yildirim A, Lubbers HT, Yildirim A. Drug-induced anaphylaxis. Adrenalin as emergency drug in anaphylaxis. Swiss Dent J. 2017;127:242–3.

    PubMed  Google Scholar 

  • Zhang Q, Liu B, Zhao L, Qi Z, Shao H, An L, Li C. Efficacy of vasopressin-epinephrine compared to epinephrine alone for out of hospital cardiac arrest patients: a systematic review and meta-analysis. Am J Emerg Med. 2017a;35:1555–60.

    Article  PubMed  Google Scholar 

  • Zhang X, Liu Q, Liao Q, Zhao Y. Potential roles of peripheral dopamine in tumor immunity. J Cancer. 2017b;8:2966–73.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Zhao W, Huang Y, Liu Z, Cao BB, Peng YP, Qiu YH. Dopamine receptors modulate cytotoxicity of natural killer cells via cAMP-PKA-CREB signaling pathway. PLoS One. 2013;8:e65860.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Zipes DP, Camm AJ, Borggrefe M, Buxton AE, Chaitman B, Fromer M, Gregoratos G, Klein G, Moss AJ, Myerburg RJ, Priori SG, Quinones MA, Roden DM, Silka MJ, Tracy C, Smith SC Jr, Jacobs AK, Adams CD, Antman EM, Anderson JL, Hunt SA, Halperin JL, Nishimura R, Ornato JP, Page RL, Riegel B, Priori SG, Blanc JJ, Budaj A, Camm AJ, Dean V, Deckers JW, Despres C, Dickstein K, Lekakis J, McGregor K, Metra M, Morais J, Osterspey A, Tamargo JL, Zamorano JL. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death). J Am Coll Cardiol. 2006;48:e247–346.

    Article  PubMed  Google Scholar 

  • Zou Z, Yuan HB, Yang B, Xu F, Chen XY, Liu GJ, Shi XY. Perioperative angiotensin-converting enzyme inhibitors or angiotensin II type 1 receptor blockers for preventing mortality and morbidity in adults. Cochrane Database Syst Rev. 2016;1:Cd009210.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ali Dabbagh M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Dabbagh, A., Tajbakhsh, A., Talebi, Z., Rajaei, S. (2018). Cardiovascular Pharmacology in Adult Patients Undergoing Cardiac Surgery. In: Dabbagh, A., Esmailian, F., Aranki, S. (eds) Postoperative Critical Care for Adult Cardiac Surgical Patients. Springer, Cham. https://doi.org/10.1007/978-3-319-75747-6_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-75747-6_4

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-75746-9

  • Online ISBN: 978-3-319-75747-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics