Skip to main content

Postoperative Pain Management in Adult Cardiac Surgery

  • Chapter
  • First Online:

Abstract

Postoperative pain management is not only a medical concern but also among the human rights; this challenging issue would be much more difficult in postoperative period of cardiac surgery patients in whom the burden of the cardiac disease and the complex perioperative events impose their heavy shadow on the decision-making process for selection of analgesic remedies for acute pain suppression.

In this chapter, a brief discussion about the pathologic mechanisms of pain and their possible risk factors and potential mechanisms is presented first, and then, analgesia methods are discussed in two main categories: pharmacologic methods (including opioids, alpha 2 agonists, nonsteroidal anti-inflammatory drugs “NSAIDs,” paracetamol, ketamine, MgSO4, gabapentin, pregabalin, multimodal analgesia, and patient-controlled analgesia) and non-pharmacologic interventions (mainly infiltration of local anesthetics, intercostal nerve block, intrapleural infiltration of local anesthetics, and neuraxial blocks, “paravertebral, intrathecal, thoracic epidural”).

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   299.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Acharya M, Dunning J. Does the use of non-steroidal anti-inflammatory drugs after cardiac surgery increase the risk of renal failure? Interact Cardiovasc Thorac Surg. 2010;11:461–7.

    Article  PubMed  Google Scholar 

  • Alzahrani T. Pain relief following thoracic surgical procedures: a literature review of the uncommon techniques. Saudi J Anaesth. 2017;11:327–31.

    Article  PubMed  PubMed Central  Google Scholar 

  • American Society of Anesthesiologists Task Force on Acute Pain Management. Practice guidelines for acute pain management in the perioperative setting: an updated report by the American Society of Anesthesiologists Task Force on Acute Pain Management. Anesthesiology. 2012;116:248–73.

    Article  Google Scholar 

  • Anselmi L, Huynh J, Duraffourd C, Jaramillo I, Vegezzi G, Saccani F, Boschetti E, Brecha NC, De Giorgio R, Sternini C. Activation of mu opioid receptors modulates inflammation in acute experimental colitis. Neurogastroenterol Motil. 2015;27:509–23.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Aryana P, Rajaei S, Bagheri A, Karimi F, Dabbagh A. Acute effect of intravenous Administration of Magnesium Sulfate on serum levels of Interleukin-6 and tumor necrosis factor-alpha in patients undergoing elective coronary bypass graft with cardiopulmonary bypass. Anesth Pain Med. 2014;4:e16316.

    Article  PubMed  PubMed Central  Google Scholar 

  • Aslan FE, Badir A, Arli SK, Cakmakci H. Patients’ experience of pain after cardiac surgery. Contemp Nurse. 2009;34:48–54.

    Article  PubMed  Google Scholar 

  • Azzopardi S, Lee G. Health-related quality of life 2 years after coronary artery bypass graft surgery. J Cardiovasc Nurs. 2009;24:232–40.

    Article  PubMed  Google Scholar 

  • Bainbridge D, Martin JE, Cheng DC. Patient-controlled versus nurse-controlled analgesia after cardiac surgery—a meta-analysis. Can J Anaesth. 2006;53:492–9.

    Article  PubMed  Google Scholar 

  • Barletta JF. Clinical and economic burden of opioid use for postsurgical pain: focus on ventilatory impairment and ileus. Pharmacotherapy. 2012;32:12S–8S.

    Article  PubMed  Google Scholar 

  • Barr AM, Tutungi E, Almeida AA. Parasternal intercostal block with ropivacaine for pain management after cardiac surgery: a double-blind, randomized, controlled trial. J Cardiothorac Vasc Anesth. 2007;21:547–53.

    Article  PubMed  CAS  Google Scholar 

  • Bektas SG, Turan S. Does high thoracic epidural analgesia with levobupivacaine preserve myocardium? A prospective randomized study. Biomed Res Int. 2015;2015:658678.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bell RF, Dahl JB, Moore RA, Kalso E. Perioperative ketamine for acute postoperative pain. Cochrane Database Syst Rev. 2006:CD004603.

    Google Scholar 

  • Bigeleisen PE, Goehner N. Novel approaches in pain management in cardiac surgery. Curr Opin Anaesthesiol. 2015;28:89–94.

    Article  PubMed  Google Scholar 

  • Blaudszun G, Lysakowski C, Elia N, Tramer MR. Effect of perioperative systemic alpha2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials. Anesthesiology. 2012;116:1312–22.

    Article  PubMed  CAS  Google Scholar 

  • Bodnar RJ. Endogenous opiates and behavior: 2011. Peptides. 2012;38(2):463–522.

    Article  PubMed  CAS  Google Scholar 

  • Boldt J, Thaler E, Lehmann A, Papsdorf M, Isgro F. Pain management in cardiac surgery patients: comparison between standard therapy and patient-controlled analgesia regimen. J Cardiothorac Vasc Anesth. 1998;12:654–8.

    Article  PubMed  CAS  Google Scholar 

  • Bosilkovska M, Walder B, Besson M, Daali Y, Desmeules J. Analgesics in patients with hepatic impairment: pharmacology and clinical implications. Drugs. 2012;72:1645–69.

    Article  PubMed  CAS  Google Scholar 

  • Boulanger A, Perreault S, Choiniere M, Prieto I, Lavoie C, Laflamme C. Intrathecal morphine after cardiac surgery. Ann Pharmacother. 2002;36:1337–43.

    Article  PubMed  CAS  Google Scholar 

  • Breivik H, Bang U, Jalonen J, Vigfusson G, Alahuhta S, Lagerkranser M. Nordic guidelines for neuraxial blocks in disturbed haemostasis from the Scandinavian Society of Anaesthesiology and Intensive Care Medicine. Acta Anaesthesiol Scand. 2010;54:16–41.

    Article  PubMed  CAS  Google Scholar 

  • Bruce J, Drury N, Poobalan AS, Jeffrey RR, Smith WC, Chambers WA. The prevalence of chronic chest and leg pain following cardiac surgery: a historical cohort study. Pain. 2003;104:265–73.

    Article  PubMed  CAS  Google Scholar 

  • Buvanendran A, Kroin JS. Multimodal analgesia for controlling acute postoperative pain. Curr Opin Anaesthesiol. 2009;22:588–93.

    Article  PubMed  Google Scholar 

  • Camilleri M, Lembo A, Katzka DA. Opioids in gastroenterology: treating adverse effects and creating therapeutic benefits. Clin Gastroenterol Hepatol. 2017;15:1338–49.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Campos JH. Fast track in thoracic anesthesia and surgery. Curr Opin Anaesthesiol. 2009;22:1–3.

    Article  PubMed  Google Scholar 

  • Caputo M, Alwair H, Rogers CA, Pike K, Cohen A, Monk C, Tomkins S, Ryder I, Moscariello C, Lucchetti V, Angelini GD. Thoracic epidural anesthesia improves early outcomes in patients undergoing off-pump coronary artery bypass surgery: a prospective, randomized, controlled trial. Anesthesiology. 2011;114:380–90.

    Article  PubMed  CAS  Google Scholar 

  • Carstensen M, Moller AM. Adding ketamine to morphine for intravenous patient-controlled analgesia for acute postoperative pain: a qualitative review of randomized trials. Br J Anaesth. 2010;104:401–6.

    Article  PubMed  CAS  Google Scholar 

  • Chaney MA. How important is postoperative pain after cardiac surgery? J Cardiothorac Vasc Anesth. 2005a;19:705–7.

    Article  PubMed  Google Scholar 

  • Chaney MA. Cardiac surgery and intrathecal/epidural techniques: at the crossroads? Can J Anaesth. 2005b;52:783–8.

    Article  PubMed  Google Scholar 

  • Chaney MA. Intrathecal and epidural anesthesia and analgesia for cardiac surgery. Anesth Analg. 2006;102:45–64.

    Article  PubMed  CAS  Google Scholar 

  • Chaney MA. Thoracic epidural anaesthesia in cardiac surgery—the current standing. Ann Card Anaesth. 2009;12:1–3.

    Article  PubMed  Google Scholar 

  • Chaney MA, Labovsky JK. Thoracic epidural anesthesia and cardiac surgery: balancing postoperative risks associated with hematoma formation and thromboembolic phenomenon. J Cardiothorac Vasc Anesth. 2005;19:768–71.

    Article  PubMed  Google Scholar 

  • Chaney MA, Furry PA, Fluder EM, Slogoff S. Intrathecal morphine for coronary artery bypass grafting and early extubation. Anesth Analg. 1997;84:241–8.

    Article  PubMed  CAS  Google Scholar 

  • Chaney MA, Nikolov MP, Blakeman BP, Bakhos M. Intrathecal morphine for coronary artery bypass graft procedure and early extubation revisited. J Cardiothorac Vasc Anesth. 1999;13:574–8.

    Article  PubMed  CAS  Google Scholar 

  • Chang CY, Challa CK, Shah J, Eloy JD. Gabapentin in acute postoperative pain management. Biomed Res Int. 2014;2014:631756.

    PubMed  PubMed Central  Google Scholar 

  • Chaudhary V, Chauhan S, Choudhury M, Kiran U, Vasdev S, Talwar S. Parasternal intercostal block with ropivacaine for postoperative analgesia in pediatric patients undergoing cardiac surgery: a double-blind, randomized, controlled study. J Cardiothorac Vasc Anesth. 2012;26:439–42.

    Article  PubMed  CAS  Google Scholar 

  • Chen LK, Wang MH, Yang HJ, Fan SZ, Chen SS. Prospective observational pharmacogenetic study of side effects induced by intravenous morphine for postoperative analgesia. Medicine. 2017a;96:e7009.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Chen Y, Qin Y, Li L, Chen J, Zhang X, Xie Y. Morphine can inhibit the growth of breast cancer MCF-7 cells by arresting the cell cycle and inducing apoptosis. Biol Pharm Bull. 2017b;40:1686–92.

    Article  PubMed  CAS  Google Scholar 

  • Chou R, Gordon DB, de Leon-Casasola OA, Rosenberg JM, Bickler S, Brennan T, Carter T, Cassidy CL, Chittenden EH, Degenhardt E, Griffith S, Manworren R, McCarberg B, Montgomery R, Murphy J, Perkal MF, Suresh S, Sluka K, Strassels S, Thirlby R, Viscusi E, Walco GA, Warner L, Weisman SJ, Wu CL. Management of postoperative pain: a clinical practice guideline from the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists’ Committee on Regional Anesthesia, Executive Committee, and Administrative Council. J Pain. 2016;17:131–57.

    Article  PubMed  Google Scholar 

  • Correll D. Chronic postoperative pain: recent findings in understanding and management. F1000Res. 2017;6:1054.

    Article  PubMed  PubMed Central  Google Scholar 

  • Cruickshank M, Henderson L, MacLennan G, Fraser C, Campbell M, Blackwood B, Gordon A, Brazzelli M. Alpha-2 agonists for sedation of mechanically ventilated adults in intensive care units: a systematic review. Health Technol Assess. 2016;20:v–xx, 1–117.

    Article  PubMed  Google Scholar 

  • Cuthbert AW. Lubiprostone targets prostanoid EP(4) receptors in ovine airways. Br J Pharmacol. 2011;162:508–20.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Dabbagh A. Clonidine: an old friend newly rediscovered. Anesth Pain. 2011;1:8–9.

    Article  Google Scholar 

  • Dabbagh A. Postoperative pain management in cardiac surgery. In: Dabbagh A, Esmailian F, Aranki S, editors. Postoperative critical care for cardiac surgical patients. 1st ed. New York: Springer; 2014. p. 257–94.

    Chapter  Google Scholar 

  • Dabbagh A, Rajaei S. The role of anesthetic drugs in liver apoptosis. Hepat Mon. 2013;13:e13162.

    Article  PubMed  PubMed Central  Google Scholar 

  • Dabbagh A, Elyasi H, Razavi SS, Fathi M, Rajaei S. Intravenous magnesium sulfate for post-operative pain in patients undergoing lower limb orthopedic surgery. Acta Anaesthesiol Scand. 2009;53:1088–91.

    Article  PubMed  CAS  Google Scholar 

  • Dabbagh A, Rajaei S, Shamsolahrar MH. The effect of intravenous magnesium sulfate on acute postoperative bleeding in elective coronary artery bypass surgery. J Perianesth Nurs. 2010;25:290–5.

    Article  PubMed  Google Scholar 

  • Dabbagh A, Moghadam SF, Rajaei S, Mansouri Z, Manaheji HS. Can repeated exposure to morphine change the spinal analgesic effects of lidocaine in rats? J Res Med Sci. 2011;16:1361–5.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Dabbagh A, Bastanifar E, Foroughi M, Rajaei S, Keramatinia AA. The effect of intravenous magnesium sulfate on serum levels of N-terminal pro-brain natriuretic peptide (NT pro-BNP) in elective CABG with cardiopulmonary bypass. J Anesth. 2013;27:693–8.

    Article  PubMed  Google Scholar 

  • Daly DJ, Myles PS. Update on the role of paravertebral blocks for thoracic surgery: are they worth it? Curr Opin Anaesthesiol. 2009;22:38–43.

    Article  PubMed  Google Scholar 

  • Dauri M, Faria S, Gatti A, Celidonio L, Carpenedo R, Sabato AF. Gabapentin and pregabalin for the acute post-operative pain management. A systematic-narrative review of the recent clinical evidences. Curr Drug Targets. 2009;10:716–33.

    Article  PubMed  CAS  Google Scholar 

  • Davies RG, Myles PS, Graham JM. A comparison of the analgesic efficacy and side-effects of paravertebral vs epidural blockade for thoracotomy—a systematic review and meta-analysis of randomized trials. Br J Anaesth. 2006;96:418–26.

    Article  PubMed  CAS  Google Scholar 

  • Derry S, Moore RA. Single dose oral celecoxib for acute postoperative pain in adults. Cochrane Database Syst Rev. 2012;3:CD004233.

    Google Scholar 

  • Dick F, Hristic A, Roost-Krahenbuhl E, Aymard T, Weber A, Tevaearai HT, Carrel TP. Persistent sensitivity disorders at the radial artery and saphenous vein graft harvest sites: a neglected side effect of coronary artery bypass grafting procedures. Eur J Cardiothorac Surg. 2011;40:221–6.

    Article  PubMed  Google Scholar 

  • Ding X, Jin S, Niu X, Ren H, Fu S, Li Q. A comparison of the analgesia efficacy and side effects of paravertebral compared with epidural blockade for thoracotomy: an updated meta-analysis. PLoS One. 2014;9:e96233.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Djafarzadeh S, Vuda M, Takala J, Jakob SM. Effect of remifentanil on mitochondrial oxygen consumption of cultured human hepatocytes. PLoS One. 2012;7:e45195.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Dolin SJ, Cashman JN, Bland JM. Effectiveness of acute postoperative pain management: I. Evidence from published data. Br J Anaesth. 2002;89:409–23.

    Article  PubMed  CAS  Google Scholar 

  • Dowling R, Thielmeier K, Ghaly A, Barber D, Boice T, Dine A. Improved pain control after cardiac surgery: results of a randomized, double-blind, clinical trial. J Thorac Cardiovasc Surg. 2003;126:1271–8.

    Article  PubMed  CAS  Google Scholar 

  • Duan L, Zhang CF, Luo WJ, Gao Y, Chen R, Hu GH. Does magnesium-supplemented cardioplegia reduce cardiac injury? A meta-analysis of randomized controlled trials. J Card Surg. 2015;30:338–45.

    Article  PubMed  Google Scholar 

  • Eason MJ, Wyatt R. Paravertebral thoracic block-a reappraisal. Anaesthesia. 1979;34:638–42.

    Article  PubMed  CAS  Google Scholar 

  • Eftekhar-Vaghefi S, Esmaeili-Mahani S, Elyasi L, Abbasnejad M. Involvement of mu opioid receptor signaling in the protective effect of opioid against 6-hydroxydopamine-induced SH-SY5Y human neuroblastoma cells apoptosis. Basic Clin Neurosci. 2015;6:171–8.

    PubMed  PubMed Central  Google Scholar 

  • Eljezi V, Duale C, Azarnoush K, Skrzypczak Y, Sautou V, Pereira B, Tsokanis I, Schoeffler P. The analgesic effects of a bilateral sternal infusion of ropivacaine after cardiac surgery. Reg Anesth Pain Med. 2012;37:166–74.

    Article  PubMed  CAS  Google Scholar 

  • Ellenberger C, Sologashvili T, Bhaskaran K, Licker M. Impact of intrathecal morphine analgesia on the incidence of pulmonary complications after cardiac surgery: a single center propensity-matched cohort study. BMC Anesthesiol. 2017;17:109.

    Article  PubMed  PubMed Central  Google Scholar 

  • Esme H, Apiliogullari B, Duran FM, Yoldas B, Bekci TT. Comparison between intermittent intravenous analgesia and intermittent paravertebral subpleural analgesia for pain relief after thoracotomy. Eur J Cardiothorac Surg. 2012;41:10–3.

    PubMed  Google Scholar 

  • Fabritius ML, Geisler A, Petersen PL, Nikolajsen L, Hansen MS, Kontinen V, Hamunen K, Dahl JB, Wetterslev J, Mathiesen O. Gabapentin for post-operative pain management—a systematic review with meta-analyses and trial sequential analyses. Acta Anaesthesiol Scand. 2016;60:1188–208.

    Article  PubMed  CAS  Google Scholar 

  • Fairley JL, Zhang L, Glassford NJ, Bellomo R. Magnesium status and magnesium therapy in cardiac surgery: a systematic review and meta-analysis focusing on arrhythmia prevention. J Crit Care. 2017;42:69–77.

    Article  PubMed  CAS  Google Scholar 

  • Ferasatkish R, Dabbagh A, Alavi M, Mollasadeghi G, Hydarpur E, Moghadam AA, Faritus ZS, Totonchi MZ. Effect of magnesium sulfate on extubation time and acute pain in coronary artery bypass surgery. Acta Anaesthesiol Scand. 2008;52:1348–52.

    Article  PubMed  CAS  Google Scholar 

  • Floettmann E, Bui K, Sostek M, Payza K, Eldon M. Pharmacologic profile of Naloxegol, a peripherally acting micro-opioid receptor antagonist, for the treatment of opioid-induced constipation. J Pharmacol Exp Ther. 2017;361:280–91.

    Article  PubMed  PubMed Central  Google Scholar 

  • Frampton C, Quinlan J. Evidence for the use of non-steroidal anti-inflammatory drugs for acute pain in the post anaesthesia care unit. J Perioper Pract. 2009;19:418–23.

    Article  PubMed  Google Scholar 

  • Fujita T, Kumamoto E. Inhibition by endomorphin-1 and endomorphin-2 of excitatory transmission in adult rat substantia gelatinosa neurons. Neuroscience. 2006;139:1095–105.

    Article  PubMed  CAS  Google Scholar 

  • Furue H, Katafuchi T, Yoshimura M. Sensory processing and functional reorganization of sensory transmission under pathological conditions in the spinal dorsal horn. Neurosci Res. 2004;48:361–8.

    Article  PubMed  Google Scholar 

  • Gallagher R, McKinley S, Dracup K. Post discharge problems in women recovering from coronary artery bypass graft surgery. Aust Crit Care. 2004;17:160–5.

    Article  PubMed  Google Scholar 

  • Gandhi K, Heitz JW, Viscusi ER. Challenges in acute pain management. Anesthesiol Clin. 2011;29:291–309.

    Article  PubMed  Google Scholar 

  • Geng X, Zhao H, Zhang S, Li J, Tian F, Feng N, Fan R, Jia M, Guo H, Cheng L, Liu J, Chen W, Pei J. Kappa-opioid receptor is involved in the cardioprotection induced by exercise training. PLoS One. 2017;12:e0170463.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • George JA, Lin EE, Hanna MN, Murphy JD, Kumar K, Ko PS, Wu CL. The effect of intravenous opioid patient-controlled analgesia with and without background infusion on respiratory depression: a meta-analysis. J Opioid Manag. 2010;6:47–54.

    Article  PubMed  Google Scholar 

  • Graterol J, Linter SP. The effects of gabapentin on acute and chronic postoperative pain after coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth. 2012;26:e26; author reply e26.

    Article  PubMed  CAS  Google Scholar 

  • Griesdale DE, Neufeld J, Dhillon D, Joo J, Sandhu S, Swinton F, Choi PT. Risk factors for urinary retention after hip or knee replacement: a cohort study. Can J Anaesth. 2011;58:1097–104.

    Article  PubMed  PubMed Central  Google Scholar 

  • Guimaraes-Pereira L. Persistent postoperative pain and the problem of strictly observational research. Pain. 2016;157:1173–4.

    Article  PubMed  Google Scholar 

  • Guimaraes-Pereira L, Farinha F, Azevedo L, Abelha F, Castro-Lopes J. Persistent postoperative pain after cardiac surgery: incidence, characterization, associated factors and its impact in quality of life. Eur J Pain. 2016a;20:1433–42.

    Article  PubMed  Google Scholar 

  • Guimaraes-Pereira L, Valdoleiros I, Reis P, Abelha F. Evaluating persistent postoperative pain in one tertiary hospital: incidence, quality of life, associated factors, and treatment. Anesth Pain Med. 2016b;6:e36461.

    Article  PubMed  PubMed Central  Google Scholar 

  • Guimaraes-Pereira L, Reis P, Abelha F, Azevedo LF, Castro-Lopes JM. Persistent postoperative pain after cardiac surgery: a systematic review with meta-analysis regarding incidence and pain intensity. Pain. 2017;158:1869–85.

    Article  PubMed  Google Scholar 

  • van Gulik L, Janssen LI, Ahlers SJ, Bruins P, Driessen AH, van Boven WJ, van Dongen EP, Knibbe CA. Risk factors for chronic thoracic pain after cardiac surgery via sternotomy. Eur J Cardiothorac Surg. 2011;40:1309–13.

    PubMed  Google Scholar 

  • Gunther T, Dasgupta P, Mann A, Miess E, Kliewer A, Fritzwanker S, Steinborn R, Schulz S. Targeting multiple opioid receptors—improved analgesics with reduced side effects? Br J Pharmacol. 2017.

    Google Scholar 

  • Guo P, East L, Arthur A. A preoperative education intervention to reduce anxiety and improve recovery among Chinese cardiac patients: a randomized controlled trial. Int J Nurs Stud. 2012;49:129–37.

    Article  PubMed  Google Scholar 

  • Hakim SM, Narouze SN. Risk factors for chronic saphenous neuralgia following coronary artery bypass graft surgery utilizing saphenous vein grafts. Pain Pract. 2015;15:720–9.

    Article  PubMed  Google Scholar 

  • Hansdottir V, Philip J, Olsen MF, Eduard C, Houltz E, Ricksten SE. Thoracic epidural versus intravenous patient-controlled analgesia after cardiac surgery: a randomized controlled trial on length of hospital stay and patient-perceived quality of recovery. Anesthesiology. 2006;104:142–51.

    Article  PubMed  CAS  Google Scholar 

  • Ho KY, Gan TJ, Habib AS. Gabapentin and postoperative pain—a systematic review of randomized controlled trials. Pain. 2006;126:91–101.

    Article  PubMed  CAS  Google Scholar 

  • Holzer P. Non-analgesic effects of opioids: management of opioid-induced constipation by peripheral opioid receptor antagonists: prevention or withdrawal? Curr Pharm Des. 2012;18(37):6010–20.

    Article  PubMed  CAS  Google Scholar 

  • Hong RA, Gibbons KM, Li GY, Holman A, Voepel-Lewis T. A retrospective comparison of intrathecal morphine and epidural hydromorphone for analgesia following posterior spinal fusion in adolescents with idiopathic scoliosis. Paediatr Anaesth. 2017;27:91–7.

    Article  PubMed  Google Scholar 

  • Horlocker TT. Complications of regional anesthesia and acute pain management. Anesthesiol Clin. 2011a;29:257–78.

    Article  PubMed  Google Scholar 

  • Horlocker TT. Regional anaesthesia in the patient receiving antithrombotic and antiplatelet therapy. Br J Anaesth. 2011b;107(Suppl 1):i96–106.

    Article  PubMed  CAS  Google Scholar 

  • Horlocker TT, Wedel DJ, Rowlingson JC, Enneking FK, Kopp SL, Benzon HT, Brown DL, Heit JA, Mulroy MF, Rosenquist RW, Tryba M, Yuan CS. Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (Third Edition). Reg Anesth Pain Med. 2010;35:64–101.

    Article  PubMed  CAS  Google Scholar 

  • Hoshijima H, Takeuchi R, Kuratani N, Nishizawa S, Denawa Y, Shiga T, Nagasaka H. Incidence of postoperative shivering comparing remifentanil with other opioids: a meta-analysis. J Clin Anesth. 2016;32:300–12.

    Article  PubMed  CAS  Google Scholar 

  • Huang AP, Sakata RK. Pain after sternotomy—review. Brazilian J Anesthesiol. 2016;66:395–401.

    Article  Google Scholar 

  • Hudcova J, McNicol E, Quah C, Lau J, Carr DB. Patient controlled opioid analgesia versus conventional opioid analgesia for postoperative pain. Cochrane Database Syst Rev. 2006:CD003348.

    Google Scholar 

  • Hughes MM, Atayee RS, Best BM, Pesce AJ. Observations on the metabolism of morphine to hydromorphone in pain patients. J Anal Toxicol. 2012;36:250–6.

    Article  PubMed  CAS  Google Scholar 

  • Ing Lorenzini K, Daali Y, Dayer P, Desmeules J. Pharmacokinetic-pharmacodynamic modelling of opioids in healthy human volunteers. A minireview. Basic Clin Pharmacol Toxicol. 2012;110:219–26.

    Article  PubMed  CAS  Google Scholar 

  • International Pain Summit of the International Association for the Study of Pain. Declaration of Montreal: declaration that access to pain management is a fundamental human right. J Pain Palliat Care Pharmacother. 2011;25:29–31.

    Article  PubMed  CAS  Google Scholar 

  • Ishii Y, Iida N, Miyauchi Y, Mackenzie PI, Yamada H. Inhibition of morphine glucuronidation in the liver microsomes of rats and humans by monoterpenoid alcohols. Biol Pharm Bull. 2012;35:1811–7.

    Article  PubMed  CAS  Google Scholar 

  • Jabbary Moghaddam M, Ommi D, Mirkheshti A, Dabbagh A, Memary E, Sadeghi A, Yaseri M. Effects of clonidine premedication upon postoperative shivering and recovery time in patients with and without opium addiction after elective leg fracture surgeries. Anesth Pain Med. 2013;2:107–10.

    Article  PubMed  PubMed Central  Google Scholar 

  • Jalkut MK. Ketorolac as an analgesic agent for infants and children after cardiac surgery: safety profile and appropriate patient selection. AACN Adv Crit Care. 2014;25:23–30; quiz 31–22.

    Article  PubMed  Google Scholar 

  • Jeleazcov C, Saari TI, Ihmsen H, Schuttler J, Fechner J. Changes in total and unbound concentrations of sufentanil during target controlled infusion for cardiac surgery with cardiopulmonary bypass. Br J Anaesth. 2012;109:698–706.

    Article  PubMed  CAS  Google Scholar 

  • Karadeniz U, Ozturk B, Yavas S, Biricik D, Saydam GS, Erdemli O, Onan B, Onan IS, Kilickan L, Sanisoglu I. Effects of epidural anesthesia on acute and chronic pain after coronary artery bypass grafting. Biomed Res Int. 2013;28:248–53.

    Google Scholar 

  • Karagoz HY, Sonmez B, Bakkaloglu B, Kurtoglu M, Erdinc M, Turkeli A, Bayazit K. Coronary artery bypass grafting in the conscious patient without endotracheal general anesthesia. Ann Thorac Surg. 2000;70:91–6.

    Article  PubMed  CAS  Google Scholar 

  • Kehlet H, Dahl JB. The value of “multimodal” or “balanced analgesia” in postoperative pain treatment. Anesth Analg. 1993;77:1048–56.

    Article  PubMed  CAS  Google Scholar 

  • Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. Lancet. 2006;367:1618–25.

    Article  PubMed  Google Scholar 

  • Khan M, Fraser A. Cox-2 inhibitors and the risk of cardiovascular thrombotic events. Ir Med J. 2012;105:119–21.

    PubMed  CAS  Google Scholar 

  • Klockgether-Radke AP. F. W. Serturner and the discovery of morphine. 200 years of pain therapy with opioids. Anasthesiol Intensivmed Notfallmed Schmerzther. 2002;37:244–9.

    Article  PubMed  CAS  Google Scholar 

  • Kocabas S, Yedicocuklu D, Yuksel E, Uysallar E, Askar F. Infiltration of the sternotomy wound and the mediastinal tube sites with 0.25% levobupivacaine as adjunctive treatment for postoperative pain after cardiac surgery. Eur J Anaesthesiol. 2008;25:842–9.

    Article  PubMed  CAS  Google Scholar 

  • Komatsu R, Turan AM, Orhan-Sungur M, McGuire J, Radke OC, Apfel CC. Remifentanil for general anaesthesia: a systematic review. Anaesthesia. 2007;62:1266–80.

    Article  PubMed  CAS  Google Scholar 

  • Kossowsky J, Donado C, Berde CB. Immediate rescue designs in pediatric analgesic trials: a systematic review and meta-analysis. Anesthesiology. 2015;122:150–71.

    Article  PubMed  CAS  Google Scholar 

  • Kuip EJ, Zandvliet ML, Koolen SL, Mathijssen RH, van der Rijt CC. A review of factors explaining variability in fentanyl pharmacokinetics; focus on implications for cancer patients. Br J Clin Pharmacol. 2017;83:294–313.

    Article  PubMed  CAS  Google Scholar 

  • Lahtinen P, Kokki H, Hendolin H, Hakala T, Hynynen M. Propacetamol as adjunctive treatment for postoperative pain after cardiac surgery. Anesth Analg. 2002;95:813–9, table of contents.

    PubMed  CAS  Google Scholar 

  • Lahtinen P, Kokki H, Hakala T, Hynynen M. S(+)-ketamine as an analgesic adjunct reduces opioid consumption after cardiac surgery. Anesth Analg. 2004;99:1295–301; table of contents.

    Article  PubMed  CAS  Google Scholar 

  • Langford RM, Mehta V. Selective cyclooxygenase inhibition: its role in pain and anaesthesia. Biomed Pharmacother. 2006;60:323–8.

    Article  PubMed  CAS  Google Scholar 

  • Ledowski T, Stein J, Albus S, MacDonald B. The influence of age and sex on the relationship between heart rate variability, haemodynamic variables and subjective measures of acute post-operative pain. Eur J Anaesthesiol. 2011;28:433–7.

    Article  PubMed  Google Scholar 

  • Ledowski T, Reimer M, Chavez V, Kapoor V, Wenk M. Effects of acute postoperative pain on catecholamine plasma levels, hemodynamic parameters, and cardiac autonomic control. Pain. 2012;153:759–64.

    Article  PubMed  CAS  Google Scholar 

  • Leffert LR, Dubois HM, Butwick AJ, Carvalho B, Houle TT, Landau R. Neuraxial anesthesia in obstetric patients receiving thromboprophylaxis with unfractionated or low-molecular-weight heparin: a systematic review of spinal epidural hematoma. Anesth Analg. 2017;125:223–31.

    Article  PubMed  Google Scholar 

  • Leung K. [6-O-methyl-11C]Diprenorphine. 2004a.

    Google Scholar 

  • Leung K. (20R)-4,5-alpha-Epoxy-17-methyl-3-hydroxy-6-[11C]methoxy-alpha,17-dimethyl-alpha- (2-phenylethyl)-6,14-ethenomorphinan-7-methanol. 2004b.

    Google Scholar 

  • Li J, Halaszynski T. Neuraxial and peripheral nerve blocks in patients taking anticoagulant or thromboprophylactic drugs: challenges and solutions. Local Reg Anesth. 2015;8:21–32.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Liu SS, Wu CL. Effect of postoperative analgesia on major postoperative complications: a systematic update of the evidence. Anesth Analg. 2007;104:689–702.

    Article  PubMed  CAS  Google Scholar 

  • Liu H, Ji F, Peng K, Applegate RL 2nd, Fleming N. Sedation after cardiac surgery: is one drug better than another? Anesth Analg. 2017a;124:1061–70.

    Article  PubMed  CAS  Google Scholar 

  • Liu X, Xie G, Zhang K, Song S, Song F, Jin Y, Fang X. Dexmedetomidine vs propofol sedation reduces delirium in patients after cardiac surgery: a meta-analysis with trial sequential analysis of randomized controlled trials. J Crit Care. 2017b;38:190–6.

    Article  PubMed  CAS  Google Scholar 

  • Loboz KK, Shenfield GM. Drug combinations and impaired renal function—the ‘triple whammy’. Br J Clin Pharmacol. 2005;59:239–43.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Mahler DA. Opioids for refractory dyspnea. Expert Rev Respir Med. 2013;7:123–34; quiz 135.

    Article  PubMed  CAS  Google Scholar 

  • Mansouri M, Bageri K, Noormohammadi E, Mirmohammadsadegi M, Mirdehgan A, Ahangaran AG. Randomized controlled trial of bilateral intrapleural block in cardiac surgery. Asian Cardiovasc Thorac Ann. 2011;19:133–8.

    Article  PubMed  Google Scholar 

  • Mathews ET, Abrams LD. Intrathecal morphine in open heart surgery. Lancet. 1980;2:543.

    Article  PubMed  CAS  Google Scholar 

  • Mugabure Bujedo B. A clinical approach to neuraxial morphine for the treatment of postoperative pain. Pain Res Treat. 2012;2012:612145.

    PubMed  PubMed Central  Google Scholar 

  • Mathews TJ, Churchhouse AM, Housden T, Dunning J. Does adding ketamine to morphine patient-controlled analgesia safely improve post-thoracotomy pain? Interact Cardiovasc Thorac Surg. 2012;14:194–9.

    Article  PubMed  Google Scholar 

  • Mota FA, Marcolan JF, Pereira MH, Milanez AM, Dallan LA, Diccini S. Comparison study of two different patient-controlled anesthesia regiments after cardiac surgery. Rev Bras Cir Cardiovasc. 2010;25:38–44.

    Article  PubMed  Google Scholar 

  • Maund E, McDaid C, Rice S, Wright K, Jenkins B, Woolacott N. Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs for the reduction in morphine-related side-effects after major surgery: a systematic review. Br J Anaesth. 2011;106:292–7.

    Article  PubMed  CAS  Google Scholar 

  • May G, Bartram T. Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. The use of intrapleural anaesthetic to reduce the pain of chest drain insertion. Emerg Med J. 2007;24:300–1.

    Article  PubMed  Google Scholar 

  • McDaid C, Maund E, Rice S, Wright K, Jenkins B, Woolacott N. Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs (NSAIDs) for the reduction of morphine-related side effects after major surgery: a systematic review. Health Technol Assess. 2010;14:1–153, iii–iv.

    Article  PubMed  CAS  Google Scholar 

  • McDonald SB, Jacobsohn E, Kopacz DJ, Desphande S, Helman JD, Salinas F, Hall RA. Parasternal block and local anesthetic infiltration with levobupivacaine after cardiac surgery with desflurane: the effect on postoperative pain, pulmonary function, and tracheal extubation times. Anesth Analg. 2005;100:25–32.

    Article  PubMed  CAS  Google Scholar 

  • McNicol ED, Ferguson MC, Hudcova J. Patient controlled opioid analgesia versus non-patient controlled opioid analgesia for postoperative pain. Cochrane Database Syst Rev. 2015:CD003348.

    Google Scholar 

  • McNicol ED, Ferguson MC, Haroutounian S, Carr DB, Schumann R. Single dose intravenous paracetamol or intravenous propacetamol for postoperative pain. Cochrane Database Syst Rev. 2016:CD007126.

    Google Scholar 

  • Michelet P, Guervilly C, Helaine A, Avaro JP, Blayac D, Gaillat F, Dantin T, Thomas P, Kerbaul F. Adding ketamine to morphine for patient-controlled analgesia after thoracic surgery: influence on morphine consumption, respiratory function, and nocturnal desaturation. Br J Anaesth. 2007;99:396–403.

    Article  PubMed  CAS  Google Scholar 

  • Moghadam MJ, Ommi D, Mirkheshti A, Shadnoush M, Dabbagh A. The effect of pretreatment with clonidine on propofol consumption in opium abuser and non-abuser patients undergoing elective leg surgery. J Res Med Sci. 2012;17:728–31.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Monico E, Quiñónez Z. Postoperative pain management in patients with congenital heart disease. In: Dabbagh A, Conte AH, Lubin L, editors. Congenital heart disease in pediatric and adult patients: anesthetic and perioperative management. 1st ed. New York: Springer; 2017. p. 871–87.

    Chapter  Google Scholar 

  • Neal JM, Bernards CM, Hadzic A, Hebl JR, Hogan QH, Horlocker TT, Lee LA, Rathmell JP, Sorenson EJ, Suresh S, Wedel DJ. ASRA practice advisory on neurologic complications in regional anesthesia and pain medicine. Reg Anesth Pain Med. 2008;33:404–15.

    Article  PubMed  PubMed Central  Google Scholar 

  • Nigro Neto C, do Amaral JL, Arnoni R, Tardelli MA, Landoni G. Intrathecal sufentanil for coronary artery bypass grafting. Braz J Anesthesiol. 2014;64:73–8.

    Article  PubMed  Google Scholar 

  • Oehler B, Mohammadi M, Perpina Viciano C, Hackel D, Hoffmann C, Brack A, Rittner HL. Peripheral interaction of Resolvin D1 and E1 with opioid receptor antagonists for antinociception in inflammatory pain in rats. Front Mol Neurosci. 2017;10:242.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ogus H, Selimoglu O, Basaran M, Ozcelebi C, Ugurlucan M, Sayin OA, Kafali E, Ogus TN. Effects of intrapleural analgesia on pulmonary function and postoperative pain in patients with chronic obstructive pulmonary disease undergoing coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth. 2007;21:816–9.

    Article  PubMed  Google Scholar 

  • van Ojik AL, Jansen PA, Brouwers JR, van Roon EN. Treatment of chronic pain in older people: evidence based choice of strong-acting opioids. Drugs Aging. 2012;29:615–25.

    Article  PubMed  Google Scholar 

  • Okitsu K, Iritakenishi T, Iwasaki M, Imada T, Kamibayashi T, Fujino Y. Paravertebral block decreases opioid administration without causing hypotension during transapical transcatheter aortic valve implantation. Heart Vessel. 2016;31:1484–90.

    Article  Google Scholar 

  • Olofsen E, Boom M, Nieuwenhuijs D, Sarton E, Teppema L, Aarts L, Dahan A. Modeling the non-steady state respiratory effects of remifentanil in awake and propofol-sedated healthy volunteers. Anesthesiology. 2010;112:1382–95.

    Article  PubMed  CAS  Google Scholar 

  • Owusu Obeng A, Hamadeh I, Smith M. Review of opioid pharmacogenetics and considerations for pain management. Pharmacotherapy. 2017;37:1105–21.

    Article  PubMed  CAS  Google Scholar 

  • Ozaki N, Ishizaki M, Ghazizadeh M, Yamanaka N. Apoptosis mediates decrease in cellularity during the regression of Arthus reaction in cornea. Br J Ophthalmol. 2001;85:613–8.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ozturk NK, Baki ED, Kavakli AS, Sahin AS, Ayoglu RU, Karaveli A, Emmiler M, Inanoglu K, Karsli B. Comparison of transcutaneous electrical nerve stimulation and parasternal block for postoperative pain management after cardiac surgery. Pain Res Manag. 2016;2016:4261949.

    Article  PubMed  PubMed Central  Google Scholar 

  • Paliwal B, Kamal M, Chauhan DS, Purohit A. Off-pump awake coronary artery bypass grafting under high thoracic epidural anesthesia. J Anaesthesiol Clin Pharmacol. 2016;32:261–2.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Papadopoulos N, Hacibaramoglu M, Kati C, Muller D, Floter J, Moritz A. Chronic poststernotomy pain after cardiac surgery: correlation of computed tomography findings on sternal healing with postoperative chest pain. Thorac Cardiovasc Surg. 2013;61(3):202–8.

    PubMed  Google Scholar 

  • Pearce A, Lockwood C, Van Den Heuvel C. The use of therapeutic magnesium for neuroprotection during global cerebral ischemia associated with cardiac arrest and cardiac bypass surgery in adults: a systematic review protocol. JBI Database System Rev Implement Rep. 2015;13:3–13.

    PubMed  Google Scholar 

  • Pergolizzi JV Jr, LeQuang JA, Berger GK, Raffa RB. The basic pharmacology of opioids informs the opioid discourse about misuse and abuse: a review. Pain Ther. 2017;6:1–16.

    Article  PubMed  PubMed Central  Google Scholar 

  • Peters ML, Sommer M, de Rijke JM, Kessels F, Heineman E, Patijn J, Marcus MA, Vlaeyen JW, van Kleef M. Somatic and psychologic predictors of long-term unfavorable outcome after surgical intervention. Ann Surg. 2007;245:487–94.

    Article  PubMed  PubMed Central  Google Scholar 

  • Pettersson PH, Jakobsson J, Owall A. Intravenous acetaminophen reduced the use of opioids compared with oral administration after coronary artery bypass grafting. J Cardiothorac Vasc Anesth. 2005;19:306–9.

    Article  PubMed  CAS  Google Scholar 

  • Phillips SN, Fernando R, Girard T. Parenteral opioid analgesia: does it still have a role? Best Pract Res Clin Anaesthesiol. 2017;31:3–14.

    Article  PubMed  Google Scholar 

  • Plein LM, Rittner HL. Opioids and the immune system—friend or foe. Br J Pharmacol. 2017.

    Google Scholar 

  • Popping DM, Elia N, Marret E, Remy C, Tramer MR. Protective effects of epidural analgesia on pulmonary complications after abdominal and thoracic surgery: a meta-analysis. Arch Surg. 2008a;143:990–9; discussion 1000.

    Article  PubMed  Google Scholar 

  • Popping DM, Zahn PK, Van Aken HK, Dasch B, Boche R, Pogatzki-Zahn EM. Effectiveness and safety of postoperative pain management: a survey of 18 925 consecutive patients between 1998 and 2006 (2nd revision): a database analysis of prospectively raised data. Br J Anaesth. 2008b;101:832–40.

    Article  PubMed  CAS  Google Scholar 

  • Rachinger-Adam B, Conzen P, Azad SC. Pharmacology of peripheral opioid receptors. Curr Opin Anaesthesiol. 2011;24:408–13.

    Article  PubMed  Google Scholar 

  • Rafiq S, Steinbruchel DA, Wanscher MJ, Andersen LW, Navne A, Lilleoer NB, Olsen PS. Multimodal analgesia versus traditional opiate based analgesia after cardiac surgery, a randomized controlled trial. J Cardiothorac Surg. 2014;9:52.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ravven S, Bader C, Azar A, Rudolph JL. Depressive symptoms after CABG surgery: a meta-analysis. Harv Rev Psychiatry. 2013;21:59–69.

    Article  PubMed  PubMed Central  Google Scholar 

  • Rawal N. Epidural technique for postoperative pain: gold standard no more? Reg Anesth Pain Med. 2012;37:310–7.

    Article  PubMed  Google Scholar 

  • Richardson J, Sabanathan S. Thoracic paravertebral analgesia. Acta Anaesthesiol Scand. 1995;39:1005–15.

    Article  PubMed  CAS  Google Scholar 

  • Richardson J, Lonnqvist PA, Naja Z. Bilateral thoracic paravertebral block: potential and practice. Br J Anaesth. 2011;106:164–71.

    Article  PubMed  CAS  Google Scholar 

  • Royse CF. High thoracic epidural anaesthesia for cardiac surgery. Curr Opin Anaesthesiol. 2009;22:84–7.

    Article  PubMed  Google Scholar 

  • Saadat H, Ziai SA, Ghanemnia M, Namazi MH, Safi M, Vakili H, Dabbagh A, Gholami O. Opium addiction increases interleukin 1 receptor antagonist (IL-1Ra) in the coronary artery disease patients. PLoS One. 2012;7:e44939.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Sangesland A, Storen C, Vaegter HB. Are preoperative experimental pain assessments correlated with clinical pain outcomes after surgery? A systematic review. Scand J Pain. 2017;15:44–52.

    Article  PubMed  Google Scholar 

  • Scarci M, Joshi A, Attia R. In patients undergoing thoracic surgery is paravertebral block as effective as epidural analgesia for pain management? Interact Cardiovasc Thorac Surg. 2010;10:92–6.

    Article  PubMed  Google Scholar 

  • Schachner T, Bonatti J, Balogh D, Margreiter J, Mair P, Laufer G, Putz G. Aortic valve replacement in the conscious patient under regional anesthesia without endotracheal intubation. J Thorac Cardiovasc Surg. 2003;125:1526–7.

    Article  PubMed  Google Scholar 

  • Schwann NM, Chaney MA. No pain, much gain? J Thorac Cardiovasc Surg. 2003;126:1261–4.

    Article  PubMed  Google Scholar 

  • Scott LJ. Fentanyl iontophoretic transdermal system: a review in acute postoperative pain. Clin Drug Investig. 2016;36:321–30.

    Article  PubMed  CAS  Google Scholar 

  • Servin F. Remifentanil; from pharmacological properties to clinical practice. Adv Exp Med Biol. 2003;523:245–60.

    Article  PubMed  CAS  Google Scholar 

  • Servin FS. Update on pharmacology of hypnotic drugs. Curr Opin Anaesthesiol. 2008;21:473–7.

    Article  PubMed  Google Scholar 

  • Servin FS, Billard V. Remifentanil and other opioids. Handb Exp Pharmacol. 2008:283–311.

    Google Scholar 

  • Smith TH, Grider JR, Dewey WL, Akbarali HI. Morphine decreases enteric neuron excitability via inhibition of sodium channels. PLoS One. 2012;7:e45251.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Stenman M, Holzmann MJ, Sartipy U. Association between preoperative depression and long-term survival following coronary artery bypass surgery—a systematic review and meta-analysis. Int J Cardiol. 2016;222:462–6.

    Article  PubMed  Google Scholar 

  • Stephens RS, Whitman GJ. Postoperative critical care of the adult cardiac surgical patient. Part I: routine postoperative care. Crit Care Med. 2015a;43:1477–97.

    Article  PubMed  CAS  Google Scholar 

  • Stephens RS, Whitman GJ. Postoperative critical care of the adult cardiac surgical patient. Part II: procedure-specific considerations, management of complications, and quality improvement. Crit Care Med. 2015b;43:1995–2014.

    Article  PubMed  Google Scholar 

  • Suzuki M. Role of N-methyl-D-aspartate receptor antagonists in postoperative pain management. Curr Opin Anaesthesiol. 2009;22:618–22.

    Article  PubMed  Google Scholar 

  • Svircevic V, Nierich AP, Moons KG, Diephuis JC, Ennema JJ, Brandon Bravo Bruinsma GJ, Kalkman CJ, van Dijk D. Thoracic epidural anesthesia for cardiac surgery: a randomized trial. Anesthesiology. 2011a;114:262–70.

    Article  PubMed  CAS  Google Scholar 

  • Svircevic V, van Dijk D, Nierich AP, Passier MP, Kalkman CJ, van der Heijden GJ, Bax L. Meta-analysis of thoracic epidural anesthesia versus general anesthesia for cardiac surgery. Anesthesiology. 2011b;114:271–82.

    Article  PubMed  CAS  Google Scholar 

  • Swartjes M, Mooren RA, Waxman AR, Arout C, Van De Wetering K, Den Hartigh J, Beijnen JH, Kest B, Dahan A. Morphine induces hyperalgesia without involvement of mu-opioid receptor or morphine-3-glucuronide. Mol Med. 2012;18(1):1320–6.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Tabatabaie O, Matin N, Heidari A, Tabatabaie A, Hadaegh A, Yazdanynejad S, Tabatabaie K. Spinal anesthesia reduces postoperative delirium in opium dependent patients undergoing coronary artery bypass grafting. Acta Anaesthesiol Belg. 2015;66:49–54.

    PubMed  CAS  Google Scholar 

  • Talebi ZPH, Dabbagh A. Cellular and molecular mechanisms in perioperative hepatic protection: a review of current interventions. J Cell Mol Anesth. 2017;2:82–93.

    Google Scholar 

  • Tanaka K, Kersten JR, Riess ML. Opioid-induced cardioprotection. Curr Pharm Des. 2014;20:5696–705.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Tejada MA, Montilla-Garcia A, Cronin SJ, Cikes D, Sanchez-Fernandez C, Gonzalez-Cano R, Ruiz-Cantero MC, Penninger JM, Vela JM, Baeyens JM, Cobos EJ. Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice. Proc Natl Acad Sci U S A. 2017;114:8396–401.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Thavaneswaran P, Rudkin GE, Cooter RD, Moyes DG, Perera CL, Maddern GJ. Brief reports: paravertebral block for anesthesia: a systematic review. Anesth Analg. 2010;110:1740–4.

    Article  PubMed  Google Scholar 

  • Toda A, Watanabe G, Matsumoto I, Tomita S, Yamaguchi S, Ohtake H. Monitoring brain oxygen saturation during awake off-pump coronary artery bypass. Asian Cardiovasc Thorac Ann. 2013;21:14–21.

    Article  PubMed  Google Scholar 

  • Tzortzopoulou A, McNicol ED, Cepeda MS, Francia MB, Farhat T, Schumann R. Single dose intravenous propacetamol or intravenous paracetamol for postoperative pain. Cochrane Database Syst Rev. 2011:CD007126.

    Google Scholar 

  • Ucak A, Onan B, Sen H, Selcuk I, Turan A, Yilmaz AT. The effects of gabapentin on acute and chronic postoperative pain after coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth. 2011;25:824–9.

    Article  PubMed  CAS  Google Scholar 

  • Valdez-Morales E, Guerrero-Alba R, Ochoa-Cortes F, Benson J, Spreadbury I, Hurlbut D, Miranda-Morales M, Lomax AE, Vanner S. Release of endogenous opioids during a chronic IBD model suppresses the excitability of colonic DRG neurons. Neurogastroenterol Motil. 2013;25:39–46.e34.

    Article  PubMed  CAS  Google Scholar 

  • Vosoughian M, Dabbagh A, Rajaei S, Maftuh H. The duration of spinal anesthesia with 5% lidocaine in chronic opium abusers compared with nonabusers. Anesth Analg. 2007;105:531–3.

    Article  PubMed  CAS  Google Scholar 

  • Walker SM, Yaksh TL. Review article: neuraxial analgesia in neonates and infants: a review of clinical and preclinical strategies for the development of safety and efficacy data. Anesth Analg. 2012;115:638–62.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Watanabe G, Tomita S, Yamaguchi S, Yashiki N. Awake coronary artery bypass grafting under thoracic epidural anesthesia: great impact on off-pump coronary revascularization and fast-track recovery. Eur J Cardiothorac Surg. 2011;40:788–93.

    PubMed  Google Scholar 

  • White PF, Rawal S, Latham P, Markowitz S, Issioui T, Chi L, Dellaria S, Shi C, Morse L, Ing C. Use of a continuous local anesthetic infusion for pain management after median sternotomy. Anesthesiology. 2003;99:918–23.

    Article  PubMed  CAS  Google Scholar 

  • Whiteside GT, Boulet JM, Walker K. The role of central and peripheral mu opioid receptors in inflammatory pain and edema: a study using morphine and DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-3-yl]-acetic acid). J Pharmacol Exp Ther. 2005;314:1234–40.

    Article  PubMed  CAS  Google Scholar 

  • Wolf AR. Effects of regional analgesia on stress responses to pediatric surgery. Paediatr Anaesth. 2012;22:19–24.

    Article  PubMed  Google Scholar 

  • Wu SY, Dun SL, Wright MT, Chang JK, Dun NJ. Endomorphin-like immunoreactivity in the rat dorsal horn and inhibition of substantia gelatinosa neurons in vitro. Neuroscience. 1999;89:317–21.

    Article  PubMed  CAS  Google Scholar 

  • Xie N, Khabbazi S, Nassar ZD, Gregory K, Vithanage T, Anand-Apte B, Cabot PJ, Sturgess D, Shaw PN, Parat MO. Morphine alters the circulating proteolytic profile in mice: functional consequences on cellular migration and invasion. FASEB J. 2017;31(12):5208–16.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Xu JT, Sun L, Lutz BM, Bekker A, Tao YX. Intrathecal rapamycin attenuates morphine-induced analgesic tolerance and hyperalgesia in rats with neuropathic pain. Transl Perioper Pain Med. 2015a;2:27–34.

    PubMed  PubMed Central  Google Scholar 

  • Xu ZZ, Kim YH, Bang S, Zhang Y, Berta T, Wang F, Oh SB, Ji RR. Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade. Nat Med. 2015b;21:1326–31.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Yamanaka T, Sadikot RT. Opioid effect on lungs. Respirology. 2013;18:255–62.

    Article  PubMed  Google Scholar 

  • Yeung JH, Gates S, Naidu BV, Wilson MJ, Gao SF. Paravertebral block versus thoracic epidural for patients undergoing thoracotomy. Cochrane Database Syst Rev. 2016;2:CD009121.

    PubMed  Google Scholar 

  • Yousefshahi F, Predescu O, Colizza M, Asenjo JF. Postthoracotomy Ipsilateral shoulder pain: a literature review on characteristics and treatment. Pain Res Manag. 2016;2016:3652726.

    Article  PubMed  PubMed Central  Google Scholar 

  • Zhang K, Li M, Peng XC, Wang LS, Dong AP, Shen SW, Wang R. The protective effects of Sufentanil pretreatment on rat brains under the state of cardiopulmonary bypass. Iran J Pharm Res. 2015a;14:559–66.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Zhang X, Zhao X, Wang Y. Dexmedetomidine: a review of applications for cardiac surgery during perioperative period. J Anesth. 2015b;29:102–11.

    Article  PubMed  Google Scholar 

  • Zhang R, Xu B, Zhang MN, Zhang T, Wang ZL, Zhao G, Zhao GH, Li N, Fang Q, Wang R. Peripheral and central sites of action for anti-allodynic activity induced by the bifunctional opioid/NPFF receptors agonist BN-9 in inflammatory pain model. Eur J Pharmacol. 2017;813:122–9.

    Article  PubMed  CAS  Google Scholar 

  • Zheng H, Schnabel A, Yahiaoui-Doktor M, Meissner W, Van Aken H, Zahn P, Pogatzki-Zahn E. Age and preoperative pain are major confounders for sex differences in postoperative pain outcome: a prospective database analysis. PLoS One. 2017;12:e0178659.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ziesenitz VC, Vaughns JD, Koch G, Mikus G, van den Anker J. Pharmacokinetics of fentanyl and its derivatives in children: a comprehensive review. Clin Pharmacokinet. 2018;57(2):125–49.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Ziyaeifard M, Azarfarin R, Golzari SE. A review of current analgesic techniques in cardiac surgery. Is epidural worth it? J Cardiovasc Thorac Res. 2014;6:133–40.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ali Dabbagh M.D. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Dabbagh, A. (2018). Postoperative Pain Management in Adult Cardiac Surgery. In: Dabbagh, A., Esmailian, F., Aranki, S. (eds) Postoperative Critical Care for Adult Cardiac Surgical Patients. Springer, Cham. https://doi.org/10.1007/978-3-319-75747-6_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-75747-6_17

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-75746-9

  • Online ISBN: 978-3-319-75747-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics