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Diffuse Alveolar Hemorrhage in Critically Ill Cancer Patients

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Oncologic Critical Care

Abstract

Diffuse alveolar hemorrhage (DAH) is a syndrome classically defined by the triad of anemia, hemoptysis, and bilateral infiltrates on chest imaging. DAH can progress rapidly toward respiratory failure and death. It is paramount that critical care practitioners be familiar with the diagnosis and treatments available for this syndrome. This chapter reviews the etiologies of DAH, the pathophysiology, the clinical presentation, and diagnostic evaluation, and concludes with the evidence supporting treatment options with a focus on DAH in the oncologic patient. The reader will be able to distinguish infectious, bland hemorrhage, and connective tissue disease-associated causes of DAH from those caused by cytotoxic drugs and graft versus host disease (GVHD). With appropriate and timely treatment, the prognosis of DAH can be dramatic improved.

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Author information

Authors and Affiliations

  1. Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, MedStar Georgetown University Hospital, Washington, DC, USA

    Brian W. Stephenson, Allen H. Roberts II & Charles A. Read

Authors
  1. Brian W. Stephenson
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  2. Allen H. Roberts II
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  3. Charles A. Read
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Corresponding author

Correspondence to Charles A. Read .

Editor information

Editors and Affiliations

  1. Department of Critical Care, University of Texas MD Anderson Cancer C Department of Critical Care, Houston, TX, USA

    Joseph L. Nates

  2. Department of Critical Care, University of Texas MD Anderson Cancer C Department of Critical Care, Houston, TX, USA

    Kristen J. Price

Section Editor information

  1. Critical Care Department, Universidad del Rosario Hospital Universitario Fundacion Santa Fe de, Bogota, Colombia, Colombia

    Yenny Cardenas

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Stephenson, B.W., Roberts, A.H., Read, C.A. (2019). Diffuse Alveolar Hemorrhage in Critically Ill Cancer Patients. In: Nates, J., Price, K. (eds) Oncologic Critical Care. Springer, Cham. https://doi.org/10.1007/978-3-319-74698-2_49-1

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  • DOI: https://doi.org/10.1007/978-3-319-74698-2_49-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-74698-2

  • Online ISBN: 978-3-319-74698-2

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