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Participation of Bacterial Lipases, Sphingomyelinases, and Phospholipases in Gram-Positive Bacterial Pathogenesis

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Health Consequences of Microbial Interactions with Hydrocarbons, Oils, and Lipids

Part of the book series: Handbook of Hydrocarbon and Lipid Microbiology ((HHLM))

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Abstract

A growing number of both Gram-positive and Gram-negative bacteria are now known to produce lipases, sphingomyelinases, and phospholipases, and many of these enzymes have been shown to be involved in bacterial pathogenesis. In this review, lipases, sphingomyelinases, and phospholipases from Gram-positive bacteria are described and their roles in furthering the entry into and growth within host cells and tissues are discussed. The importance of phospholipases and sphingomyelinases in infections caused by Clostridium perfringens and Listeria monocytogenes have been demonstrated by many studies on the wild type and mutant forms of these enzymes. The significance of lipases, sphingomyelinases, and phospholipases for other infectious organisms including Staphylococcus aureus, Bacillus anthracis, and Mycobacterium tuberculosis is also discussed.

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  1. Department of Microbiology, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA

    Howard Goldfine

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    Howard Goldfine

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Goldfine, H. (2019). Participation of Bacterial Lipases, Sphingomyelinases, and Phospholipases in Gram-Positive Bacterial Pathogenesis. In: Goldfine, H. (eds) Health Consequences of Microbial Interactions with Hydrocarbons, Oils, and Lipids. Handbook of Hydrocarbon and Lipid Microbiology . Springer, Cham. https://doi.org/10.1007/978-3-319-72473-7_39-1

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