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Encyclopedia of Signaling Molecules pp 1919–1927Cite as

G Protein Beta/Gamma

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Synonyms

G beta; G gamma; G protein beta; G protein gamma; Gb; Gnb; Gng; Guanine nucleotide binding protein; Guanine nucleotide binding protein (G protein), gamma; Guanine nucleotide binding protein, beta; Guanine nucleotide binding protein, beta polypeptide; Guanine nucleotide binding protein, gamma

Isoforms

Five different isoforms of Gbeta have been identified, numbered 1 to 5. Ggamma isoforms are numbered from 1 to 5 and 7 to 13.

G protein beta5 can also be known as Flailer, Flail, Flr, Hug.

G protein gamma2 is also known as G protein gamma6.

Historical Background

G protein β and γ subunits were first discovered as components of G proteins over 30 years ago. Since then, their role has evolved significantly from simple inhibitors of G protein α subunits to independent signaling regulators modulating a number of different cellular effectors. Although several isoforms of Gα were cloned in the early 1980s, it was not until 1986 that the transducin Gβ subunit was cloned (Fong et al. 1986...

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Author information

Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada

    Denis J. Dupré

  2. Department of Pharmacology and Therapeutics, McGill University, Montréal, QC, Canada

    Terence E. Hébert

Authors
  1. Denis J. Dupré
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  2. Terence E. Hébert
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Corresponding author

Correspondence to Denis J. Dupré .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Dupré, D.J., Hébert, T.E. (2018). G Protein Beta/Gamma. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_75

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