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Encyclopedia of Signaling Molecules pp 4445–4454Cite as

RANK and RANKL

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RANK and RANKL Family Members

RANK; receptor activator of nuclear factor-κB, TNFRSF11A; tumor necrosis factor receptor superfamily, member 11a, CD265. RANKL; receptor activator of nuclear factor-κB ligand, TNFSF11; tumor necrosis factor (ligand) superfamily, member 11, OPGL; osteoprotegerin ligand, ODF; osteoclast differentiation factor, TRANCE; TNF-related activation-induced cytokine, CD254.

Historical Background

In the late 1980s, an in vitro coculture system for osteoclast formation was established. This system was shown to require cell-to-cell contact between calvarial cells and bone marrow cells for osteoclast differentiation (Suda et al. 1999). Based on this finding, it was proposed that osteoclastogenesis-supporting mesenchymal lineage cells express an osteoclast differentiation factor (ODF) in the form of a membrane-associated protein (Suda et al. 1999). In the late 1990s, the potential inhibitor of osteoclastogenesis osteoprotegerin (OPG) was cloned. OPG is a decoy receptor...

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Authors and Affiliations

  1. Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Yushima 1-5-45,, Bunkyo-ku, Tokyo, 113-8549, Japan

    Tomoki Nakashima & Hiroshi Takayanagi

  2. Japan Science and Technology Agency (JST), Explorative Research for Advanced Technology (ERATO) Program, Takayanagi Osteonetwork Project, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113-8549, Japan

    Tomoki Nakashima & Hiroshi Takayanagi

  3. Global Center of Excellence (GCOE) Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113-8549, Japan

    Hiroshi Takayanagi

Authors
  1. Tomoki Nakashima
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  2. Hiroshi Takayanagi
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Correspondence to Hiroshi Takayanagi .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Nakashima, T., Takayanagi, H. (2018). RANK and RANKL. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_633

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