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Encyclopedia of Signaling Molecules pp 5979–5986Cite as

WASH

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Synonyms

WASP and SCAR homolog; Wiskott-Aldrich syndrome protein and SCAR homolog

Historical Background

WASH (Wiskott-Aldrich Syndrome Protein and SCAR Homolog) was initially identified in 2007 as a novel member of the WASP (Wiskott-Aldrich Syndrome Protein) superfamily of nucleation-promoting factors (NPFs) (Linardopoulou et al. 2007). In addition to WASH, this family includes the founding member WASP as well as N-WASP (Neuronal Wiskott–Aldrich Syndrome Protein), three WAVE/SCAR (WASP family Verprolin-homologous protein/Suppressor of cAR) isoforms, WHAMM (WASP Homolog associated with Actin, Membranes, and Microtubules), and JMY (Junction Mediating and Regulatory Protein) (Campellone and Welch 2010). WASH orthologs are evolutionarily conserved from humans through Entameba and WASH mRNA (Messenger RNA) is ubiquitously expressed in human tissues (Linardopoulou et al. 2007). Further work comparing known genome sequences revealed that WASH is conserved down to the green algae Ostreocuccus...

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Author information

Authors and Affiliations

  1. Department of Immunology, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA

    Joshua T. Piotrowski & Daniel D. Billadeau

  2. Division of Oncology Research, Schulze Center for Novel Therapeutics, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA

    Daniel D. Billadeau

Authors
  1. Joshua T. Piotrowski
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  2. Daniel D. Billadeau
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Corresponding author

Correspondence to Joshua T. Piotrowski .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Piotrowski, J.T., Billadeau, D.D. (2018). WASH. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_631

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