Synonyms
Historical Background
CCL5 was initially described in 1988 and this new protein was named for its characteristics: Regulated upon Activation expressed by Normal T cells and presumably Secreted (RANTES) (Schall et al. 1988). A relatively new technology, at the time, was used to identify RANTES, subtraction cDNA libraries, which help to distinguish genes expressed in one cell and not in another. This genetic approach has since led to the uncovering of about 50 other chemokines, and in order to clarify the nomenclature of all chemokines and their receptors, a new nomenclature has been introduced, in which RANTES has been renamed CCL5 (Zlotnik and Yoshie 2000). CCL5 was first discovered in T cell-specific cDNA, and this initial report on CCL5 placed further attention on a new family of chemotactic proteins that proved to be important in influencing a series of biologic and pathological processes (Levy 2009).
Collectively, chemokines are defined as small (8–14 kDa) proteins...
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Appay V, Rowland-Jones SL. RANTES: a versatile and controversial chemokine. Trends Immunol. 2001;22(2):83–7.
Barrios CS, Castillo L, Giam C, Wu L, Beilke MA. Inhibition of HIV type 1 replication by human T lymphotropic virus types 1 and 2 tax proteins in vitro. AIDS Res Hum Retrovir. 2013;29(7):1061–7.
Bianchi R, Kastrisianaki E, Giambanco I, Donato R. S100B protein stimulates microglia migration via RAGE-dependent up-regulation of chemokine expression and release. J Biol Chem. 2011;286(9):7214–26.
Carrington M, Dean M, Martin MP, O’Brien SJ. Genetics of HIV-1 infection: chemokine receptor CCR5 polymorphism and its consequences. Hum Mol Genet. 1999;8(10):1939–45.
Cheng JF, Jack R. CCR1 antagonists. Mol Divers. 2008;12(1):17–23.
Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science. 1995;270(5243):1811–5.
Conti P, DiGioacchino M. MCP-1 and RANTES are mediators of acute and chronic inflammation. Allergy Asthma Proc. 2001;22(3):133–7.
Doodes PD, Cao Y, Hamel KM, Wang Y, Rodeghero RL, Kobezda T, et al. CCR5 is involved in resolution of inflammation in proteoglycan-induced arthritis. Arthritis Rheum. 2009;60(10):2945–53.
Graziano FM, Cook EB, Stahl JL. Cytokines, chemokines, RANTES, and eotaxin. Allergy Asthma Proc. 1999;20(3):141–6.
Horuk R. Chemokine receptors. Cytokine Growth Factor Rev. 2001;12(4):313–35.
Ishida T, Ueda R. CCR4 as a novel molecular target for immunotherapy of cancer. Cancer Sci. 2006;97(11):1139–46.
Levy JA. The unexpected pleiotropic activities of RANTES. J Immunol. 2009;182(7):3945–6.
Maurer M, von Stebut E. Macrophage inflammatory protein-1. Int J Biochem Cell Biol. 2004;36(10):1882–6.
Menten P, Wuyts A, Van Damme J. Macrophage inflammatory protein-1. Cytokine Growth Factor Rev. 2002;13(6):455–81.
Neote K, DiGregorio D, Mak JY, Horuk R, Schall TJ. Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. Cell. 1993;72(3):415–25.
Power CA, Meyer A, Nemeth K, Bacon KB, Hoogewerf AJ, Proudfoot AE, et al. Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line. J Biol Chem. 1995;270(33):19495–500.
Proudfoot AE, Power CA, Hoogewerf AJ, Montjovent MO, Borlat F, Offord RE, et al. Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist. J Biol Chem. 1996;271(5):2599–603.
Ramírez-Martínez G, Cruz-Lagunas A, Jiménez-Alvarez L, Espinosa E, Ortíz-Quintero B, Santos-Mendoza T, et al. Seasonal and pandemic influenza H1N1 viruses induce differential expression of SOCS-1 and RIG-I genes and cytokine/chemokine production in macrophages. Cytokines. 2013;62(1):151–9.
Repeke CE, Ferreira Jr SB, Claudino M, Silveira EM, de Assis GF, Avila-Campos MJ, et al. Evidences of the cooperative role of the chemokines CCL3, CCL4 and CCL5 and its receptors CCR1+ and CCR5+ in RANKL+ cell migration throughout experimental periodontitis in mice. Bone. 2010;46(4):1122–30.
Samson M, Labbe O, Mollereau C, Vassart G, Parmentier M. Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochemistry. 1996;35(11):3362–7.
Schall TJ, Jongstra J, Dyer BJ, Jorgensen J, Clayberger C, Davis MM, et al. A human T cell-specific molecule is a member of a new gene family. J Immunol. 1988;141(3):1018–25.
Wells TN, Proudfoot AE, Power CA. Chemokine receptors and their role in leukocyte activation. Immunol Lett. 1999;65(1–2):35–40.
Zhang Q, Qin J, Zhong L, Gong L, Zhang B, Zhang Y, et al. CCL5-mediated Th2 immune polarization promotes metastasis in luminal breast cancer. Cancer Res. 2015;75(20):4312–21.
Zlotnik A, Yoshie O. Chemokines: a new classification system and their role in immunity. Immunity. 2000;12(2):121–7.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this entry
Cite this entry
Repeke, C.E., Garlet, T.P., Vieira, A.E., Broll, D., Cunha, F.Q., Garlet, G.P. (2018). CCL5. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_580
Download citation
DOI: https://doi.org/10.1007/978-3-319-67199-4_580
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-67198-7
Online ISBN: 978-3-319-67199-4
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences