Synonyms
Historical Background
Integrin α1 subunit forms a heterodimer with integrin β1 subunit and acts as a cellular collagen receptor. α1β1 is one of the first integrins found, and it was originally described as T lymphocyte very late activation antigen-1 (VLA-1). Today the human integrin family is known to contain 24 α/β heterodimers that mediate adhesion to extracellular matrix (ECM), plasma proteins, or counter receptors on other cells. The cytoplasmic domains of integrin α and β subunits are connected to cytoskeletal filaments and also to multiple cellular signaling pathways (Hynes 2004).
Structure
Integrins are single-pass type I membrane glycoproteins. Integrin α1 subunit contains short intracellular domain, transmembrane anchor, and an extracellular part, composed of α1I, β-propeller, thigh, calf-1, and calf-2 domains (Fig. 1). Thus, α1 belongs to a subgroup of integrins that contain an αI domain (inserted domain that is often...
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References
Arnaout MA, Goodman SL, Xiong JP. Structure and mechanics of integrin-based cell adhesion. Curr Opin Cell Biol. 2007;19:495–507.
Ben-Horin S, Bank I. The role of very late antigen-1 in immune-mediated inflammation. Clin Immunol. 2004;113:119–29.
Eble JA. Matrix biology meets toxinology. Matrix Biol. 2010;29:239–47.
Gardner H. Integrin α1β1. Adv Exp Med Biol. 2014;819:21–39.
Heino J. The collagen family members as cell adhesion proteins. Bioessays. 2007;29:1001–10.
Heino J. Cellular signaling by collagen-binding integrins. Adv Exp Med Biol. 2014;819:143–55.
Herr AB, Farndale RW. Structural insights into the interactions between platelet receptors and fibrillar collagen. J Biol Chem. 2009;284:19781–5.
Hynes RO. The emergence of integrins: a personal and historical perspective. Matrix Biol. 2004;23:333–40.
Ivaska J, Heino J. Cooperation between integrins and growth factor receptors in signaling and endocytosis. Annu Rev Cell Dev Biol. 2011;27:291–320.
Johnson MS, Lu N, Denessiouk K, Heino J, Gullberg D. Integrins during evolution: evolutionary trees and model organisms. Biochim Biophys Acta. 1788;2009:779–89.
Legate KR, Fässler R. Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails. J Cell Sci. 2009;122:187–98.
Leitinger B. Transmembrane collagen receptors. Annu Rev Cell Dev Biol. 2011;27:265–90.
Luo BH, Carman CV, Springer TA. Structural basis of integrin regulation and signaling. Annu Rev Immunol. 2007;25:619–47.
Pozzi A, Voziyan PA, Hudson BG, Zent R. Regulation of matrix synthesis, remodeling and accumulation in glomerulosclerosis. Curr Pharm Des. 2009;15:1318–33.
Zeltz C, Gullberg D. The integrin-collagen connection-a glue for tissue repair? J Cell Sci. 2016;129:653–64.
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Heino, J. (2018). Integrin α1 (ITGA1). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_556
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DOI: https://doi.org/10.1007/978-3-319-67199-4_556
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