Skip to main content
SpringerLink
Log in

PTPe (RPTPe and Cyt-PTPe)

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 70 Accesses

Synonyms

cyt-PTPe; PTP Epsilon; PTPe; PTPeC; PTPeM; RPTPe; tm-PTPe

Historical Background

Phosphorylation of tyrosine residues in proteins is one of the better-studied molecular mechanisms for regulating protein structure and function and with it – the function of cells and organisms. Tyrosine phosphorylation is a reversible process that is controlled by the opposing activities of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). The numbers of PTKs and PTPs are similar and small relative to the numbers of their potential substrates; there are 81 and 85 genes that yield active, protein-specific PTPs and PTKs, respectively (Alonso et al. 2004). As a result, individual PTPs and PTKs each target multiple substrates and fulfill distinct roles in different physiological systems. Although PTPs were first described in molecular terms in 1988, about a decade after PTKs, both protein superfamilies are now recognized as critical regulators of protein phosphorylation and...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 4,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 4,499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Aga-Mizrachi S, Brutman-Barazani T, Jacob AI, Bak A, Elson A, Sampson SR. Cytosolic protein tyrosine phosphatase-epsilon is a negative regulator of insulin signaling in skeletal muscle. Endocrinology. 2008;149(2):605–14.

    Article  CAS  PubMed  Google Scholar 

  • Akimoto M, Mishra K, Lim KT, Tani N, Hisanaga SI, Katagiri T, et al. Protein tyrosine phosphatase epsilon is a negative regulator of FcepsilonRI-mediated mast cell responses. Scand J Immunol. 2009;69(5):401–11.

    Article  CAS  PubMed  Google Scholar 

  • Alonso A, Sasin J, Bottini N, Friedberg I, Osterman A, Godzik A, et al. Protein tyrosine phosphatases in the human genome. Cell. 2004;117(6):699–711.

    Article  CAS  PubMed  Google Scholar 

  • Andersen JN, Elson A, Lammers R, Romer J, Clausen JT, Moller KB, et al. Comparative study of protein tyrosine phosphatase-epsilon isoforms: membrane localization confers specificity in cellular signalling. Biochem J. 2001a;354(Pt 3):581–90.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Andersen JN, Mortensen OH, Peters GH, Drake PG, Iversen LF, Olsen OH, et al. Structural and evolutionary relationships among protein tyrosine phosphatase domains. Mol Cell Biol. 2001b;21(21):7117–36.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Berman-Golan D, Elson A. Neu-mediated phosphorylation of protein tyrosine phosphatase epsilon is critical for activation of Src in mammary tumor cells. Oncogene. 2007;26(49):7028–37.

    Article  CAS  PubMed  Google Scholar 

  • De Franceschi L, Biondani A, Carta F, Turrini F, Laudanna C, Deana R, et al. PTPepsilon has a critical role in signaling transduction pathways and phosphoprotein network topology in red cells. Proteomics. 2008;8(22):4695–708.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • den Hertog J, Ostman A, Bohmer FD. Protein tyrosine phosphatases: regulatory mechanisms. FEBS J. 2008;275(5):831–47.

    Article  CAS  Google Scholar 

  • Elson A. Protein tyrosine phosphatase epsilon increases the risk of mammary hyperplasia and mammary tumors in transgenic mice. Oncogene. 1999;18(52):7535–42.

    Article  CAS  PubMed  Google Scholar 

  • Elson A, Leder P. Identification of a cytoplasmic, phorbol ester-inducible isoform of protein tyrosine phosphatase epsilon. Proc Natl Acad Sci USA. 1995a;92(26):12235–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Elson A, Leder P. Protein-tyrosine phosphatase epsilon. An isoform specifically expressed in mouse mammary tumors initiated by v-Ha-ras OR neu. J Biol Chem. 1995b;270(44):26116–22.

    Article  CAS  PubMed  Google Scholar 

  • Gil-Henn H, Elson A. Tyrosine phosphatase-epsilon activates Src and supports the transformed phenotype of Neu-induced mammary tumor cells. J Biol Chem. 2003;278(18):15579–86.

    Article  CAS  PubMed  Google Scholar 

  • Gil-Henn H, Volohonsky G, Toledano-Katchalski H, Gandre S, Elson A. Generation of novel cytoplasmic forms of protein tyrosine phosphatase epsilon by proteolytic processing and translational control. Oncogene. 2000;19(38):4375–84.

    Article  CAS  PubMed  Google Scholar 

  • Gil-Henn H, Volohonsky G, Elson A. Regulation of protein-tyrosine phosphatases alpha and epsilon by calpain-mediated proteolytic cleavage. J Biol Chem. 2001;276(34):31772–9.

    Article  CAS  PubMed  Google Scholar 

  • Granot-Attas S, Luxenburg C, Finkelshtein E, Elson A. PTP epsilon regulates integrin-mediated podosome stability in osteoclasts by activating src. Mol Biol Cell. 2009;20(20):4324–34.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hendriks WJ, Elson A, Harroch S, Stoker AW. Protein tyrosine phosphatases: functional inferences from mouse models and human diseases. FEBS J. 2008;275(5):816–30.

    Article  CAS  PubMed  Google Scholar 

  • Krueger NX, Streuli M, Saito H. Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. EMBO J. 1990;9:3241–52.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Muja N, Lovas G, Romm E, Machleder D, Ranjan M, Gallo V, et al. Expression of a catalytically inactive transmembrane protein tyrosine phosphatase epsilon (tm-PTP epsilon) delays optic nerve myelination. Glia. 2004;48(4):278–97.

    Article  PubMed  Google Scholar 

  • Nakagawa Y, Yamada N, Shimizu H, Shiota M, Tamura M, Kim-Mitsuyama S, et al. Tyrosine phosphatase epsilonM stimulates migration and survival of porcine aortic endothelial cells by activating c-Src. Biochem Biophys Res Commun. 2004;325(1):314–9.

    Article  CAS  PubMed  Google Scholar 

  • Nakagawa Y, Aoki N, Aoyama K, Shimizu H, Shimano H, Yamada N, et al. Receptor-type protein tyrosine phosphatase epsilon (PTPepsilonM) is a negative regulator of insulin signaling in primary hepatocytes and liver. Zool Sci. 2005;22(2):169–75.

    Article  CAS  Google Scholar 

  • Nakamura K, Mizuno Y, Kikuchi K. Molecular cloning of a novel cytoplasmic protein tyrosine phosphatase PTP epsilon. Biochem Biophys Res Commun. 1996;218:726–32.

    Article  CAS  PubMed  Google Scholar 

  • Peretz A, Gil-Henn H, Sobko A, Shinder V, Attali B, Elson A. Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon. EMBO J. 2000;19:4036–45.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Rousso-Noori L, Knobler H, Levy-Apter E, Kuperman Y, Neufeld-Cohen A, Keshet Y, et al. Protein tyrosine phosphatase epsilon affects body weight by downregulating leptin signaling in a phosphorylation-dependent manner. Cell Metab. 2011;13(5):562–72.

    Article  CAS  PubMed  Google Scholar 

  • Sines T, Granot-Attas S, Weisman-Welcher S, Elson A. Association of tyrosine phosphatase epsilon with microtubules inhibits phosphatase activity and is regulated by the epidermal growth factor receptor. Mol Cell Biol. 2007;27(20):7102–12.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Sully V, Pownall S, Vincan E, Bassal S, Borowski AH, Hart PH, et al. Functional abnormalities in protein tyrosine phosphatase epsilon-deficient macrophages. Biochem Biophys Res Commun. 2001;286:184–8.

    Article  CAS  PubMed  Google Scholar 

  • Tanuma N, Nakamura K, Kikuchi K. Distinct promoters control transmembrane and cytosolic protein tyrosine phosphatase epsilon expression during macrophage differentiation. Eur J Biochem. 1999;259:46–54.

    Article  CAS  PubMed  Google Scholar 

  • Tanuma N, Shima H, Nakamura K, Kikuchi K. Protein tyrosine phosphatase epsilonC selectively inhibits interleukin-6- and interleukin- 10-induced JAK-STAT signaling. Blood. 2001;98:3030–4.

    Article  CAS  PubMed  Google Scholar 

  • Tanuma N, Shima H, Shimada S, Kikuchi K. Reduced tumorigenicity of murine leukemia cells expressing protein-tyrosine phosphatase, PTPepsilon C. Oncogene. 2003;22(12):1758–62.

    Article  CAS  PubMed  Google Scholar 

  • Thompson LJ, Jiang J, Madamanchi N, Runge MS, Patterson C. PTP-epsilon, a tyrosine phosphatase expressed in endothelium, negatively regulates endothelial cell proliferation. Am J Physiol Heart Circ Physiol. 2001;281:H396–403.

    Article  CAS  PubMed  Google Scholar 

  • Toledano-Katchalski H, Tiran Z, Sines T, Shani G, Granot-Attas S, den Hertog J, et al. Dimerization in vivo and inhibition of the nonreceptor form of protein tyrosine phosphatase epsilon. Mol Cell Biol. 2003;23(15):5460–71.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Tonks NK. Protein tyrosine phosphatases: from genes, to function, to disease. Nat Rev Mol Cell Biol. 2006;7(11):833–46.

    Article  CAS  PubMed  Google Scholar 

  • Wabakken T, Hauge H, Funderud S, Aasheim HC. Characterization, expression and functional aspects of a novel protein tyrosine phosphatase epsilon isoform. Scand J Immunol. 2002;56(3):276–85.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular Genetics, Arnold R. Meyer Institute of Biological Sciences, The Weizmann Institute of Science, Rehovot, 76100, Israel

    Ari Elson & Liat Rousso-Noori

Authors
  1. Ari Elson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Liat Rousso-Noori
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ari Elson .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Elson, A., Rousso-Noori, L. (2018). PTPe (RPTPe and Cyt-PTPe). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_525

Download citation

Publish with us

Policies and ethics

Search

Navigation