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Encyclopedia of Signaling Molecules pp 951–962Cite as

CD72

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Synonyms

CD72 antigen; Ly-19; Ly-32; Ly-m19; Lyb-2

Historical Background

B lymphocytes express several surface molecules other than the B cell receptors (BCR) that function as markers of differentiation as well as molecules that can fine tune BCR signaling. Current research has identified a function for most antigens that were previously classified as markers of lymphocyte differentiation. CD72 is one such molecule that was originally discovered as a marker of B cell differentiation using conventional serological and classical genetic techniques. Subsequently generation of monoclonal antibodies helped its definition as a molecule that can affect B cell growth and differentiation on its own or in the context of BCR signaling. Initially Sato and Boyse described an activity in sera from C3H.I mice immunized with 1.29 ascites tumor cells that reacted only with a subset of spleen cells after it was absorbed to remove an unknown reactivity. Subsequently the cell type in the spleen recognized...

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Author information

Authors and Affiliations

  1. Department of Microbiology and Immunology, University of Arizona, Tucson, AZ, 85721, USA

    Hsin-Jung Wu

  2. Division of Hematology, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, Ohio State University, Columbus, OH, 43210, USA

    Natarajan Muthusamy

  3. Department of Microbiology, Immunology and Molecular Genetics, Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA

    Subbarao Bondada

Authors
  1. Hsin-Jung Wu
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  2. Natarajan Muthusamy
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  3. Subbarao Bondada
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Corresponding author

Correspondence to Hsin-Jung Wu .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Wu, HJ., Muthusamy, N., Bondada, S. (2018). CD72. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_461

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