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Phosphatidylinositol 5-Phosphate 4-Kinase

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

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Synonyms

PI5P4K; PI5P4K2; PIP kinase; PIP4K; PIP4K2; PIP5K2; PIPKII; PIPkin; PtdIns(5)P 4-kinase; PtdInsP kinase type II; Type II PIP kinase; Type II PIPK

Historical Background

Phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) is an enzyme activity capable of converting a monophosphorylated lipid substrate into a bisphosphorylated product, a reaction that is fundamental in the maintenance of the cellular phosphoinositide (PI) cycle. PI5P4K catalyzes the addition of a phosphate group to position D-4 of the inositol head-group of PtdIns5P (Figs. 1 and 2). Downstream effects of signaling molecules generated by the PI cycle are diverse and include vesicle trafficking, ion channel activity, cytoskeletal dynamics, cell differentiation, proliferation, and apoptosis (Di Paolo and De Camilli 2006; Balla 2016; Viaud et al. 2016).

Phosphatidylinositol 5-Phosphate 4-Kinase, Fig. 1
figure 1769 figure 1769

Molecular structure of PtdIns (1[stearoyl], 2[arachidonoyl]-diacyl-sn-glycero-3-phospho-[1-d-myo-inositol])....

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Authors and Affiliations

  1. Alzheimer’s Research UK Cambridge Drug Discovery Institute, Cambridge Biomedical Campus, University of Cambridge, Island Research Building, Hills Road, CB2 0AH, Cambridge, UK

    Jonathan H. Clarke

  2. Department of Pharmacology, University of Cambridge, Tennis Court Road, CB2 1PD, Cambridge, UK

    Robin F. Irvine

Authors
  1. Jonathan H. Clarke
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  2. Robin F. Irvine
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Correspondence to Jonathan H. Clarke .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Clarke, J.H., Irvine, R.F. (2018). Phosphatidylinositol 5-Phosphate 4-Kinase. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_418

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