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RSK (p90 Ribosomal S6 Kinase)

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 142 Accesses

Synonyms

90 kDa ribosomal S6 kinase; p90RSK

Historical Background

The p90 ribosomal S6 kinase (RSK) family comprises four mammalian Ser/Thr kinases (RSK1-4) (Romeo et al. 2012). The first RSK family member was identified as a kinase activity in maturating Xenopus laevis oocytes that phosphorylated the 40S ribosomal subunit protein S6 (rpS6) (Erikson and Maller 1985, 1986). Although the p70 ribosomal S6 kinases 1 and 2 (S6K1 and S6K2) were later shown to be the predominant S6 kinases operating in somatic cells (Blenis et al. 1991; Chung et al. 1992), RSK1 and RSK2 were found to phosphorylate rpS6 in response to ERK1/ERK2 pathway activation (Cohen et al. 2005; Roux et al. 2007). Interestingly, whereas S6K1/S6K2 phosphorylate all sites on rpS6 (Ser235, Ser236, Ser240, and Ser244), RSK1 and RSK2 were shown to specifically phosphorylate Ser235 and Ser236 (Roux et al. 2007). It should be noted, however, that the molecular mechanism(s) underlying the diverse effects of rpS6 phosphorylation...

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Authors and Affiliations

  1. Institute for Research in Immunology and Cancer (IRIC), Department of Pathology and Cell Biology, Faculty of Medicine, Université de Montréal, Station Centre-Ville, Montreal, Box 6128, Montreal, QC, H3C 3J7, Canada

    Philippe P. Roux

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  1. Philippe P. Roux
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Correspondence to Philippe P. Roux .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Roux, P.P. (2018). RSK (p90 Ribosomal S6 Kinase). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_382

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