Skip to main content

Rap GEF Family

  • Reference work entry
  • First Online:
Book cover Encyclopedia of Signaling Molecules
  • 91 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 4,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 4,499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Banerjee U, Cheng X. Exchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: structure, function and therapeutics. Gene. 2015;570(2):157–67.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bithell A, Hsu T, Kandanearatchi A, Landau S, Everall IP, Tsuang MT, et al. Expression of the Rap1 guanine nucleotide exchange factor, MR-GEF, is altered in individuals with bipolar disorder. PLoS One. 2010;5(4):e10392.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Borland G, Smith BO, Yarwood SJ. EPAC proteins transduce diverse cellular actions of cAMP. Br J Pharmacol. 2009;158(1):70–86.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Cox AD, Fesik SW, Kimmelman AC, Luo J, Der CJ. Drugging the undruggable RAS: mission possible? Nat Rev Drug Discov. 2014;13(11):828–51.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gloerich M, Bos JL. Regulating Rap small G-proteins in time and space. Trends Cell Biol. 2011;21(10):615–23.

    Article  PubMed  CAS  Google Scholar 

  • Hamel B, Monaghan-Benson E, Rojas RJ, Temple BR, Marston DJ, Burridge K, et al. SmgGDS is a guanine nucleotide exchange factor that specifically activates RhoA and RhoC. J Biol Chem. 2011;286(14):12141–8.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hobbs GA, Der CJ, Rossman KL. RAS isoforms and mutations in cancer at a glance. J Cell Sci. 2016;129(7):1287–92.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hong KW, Jin HS, Lim JE, Ryu HJ, Go MJ, Lee JY, et al. RAPGEF1 gene variants associated with type 2 diabetes in the Korean population. Diabetes Res Clin Pract. 2009;84(2):117–22.

    Article  PubMed  CAS  Google Scholar 

  • Li Y, Asuri S, Rebhun JF, Castro AF, Paranavitana NC, Quilliam LA. The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane. J Biol Chem. 2006;281(5):2506–14.

    Article  PubMed  CAS  Google Scholar 

  • Maeta K, Edamatsu H, Nishihara K, Ikutomo J, Bilasy SE, Kataoka T. Crucial role of Rapgef2 and Rapgef6, a family of guanine nucleotide exchange factors for Rap1 small GTPase, in formation of apical surface adherens junctions and neural progenitor development in the mouse cerebral cortex. eNeuro. 2016;3(3):1–17.

    Article  Google Scholar 

  • Quilliam LA, Rebhun JF, Castro AF. A growing number of guanine nucleotide exchange factors is responsible for activation of ras family GTPases. Prog Nucleic Acid Res Mol Biol. 2002;71:391–444.

    Article  PubMed  CAS  Google Scholar 

  • Sakurai A, Fukuhara S, Yamagishi A, Sako K, Kamioka Y, Masuda M, et al. MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion. Mol Biol Cell. 2006;17(2):966–76.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Satyanarayana A, Gudmundsson KO, Chen X, Coppola V, Tessarollo L, Keller JR, et al. RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis. Blood. 2010;116(16):2921–31.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Severson EA, Lee WY, Capaldo CT, Nusrat A, Parkos CA. Junctional adhesion molecule A interacts with Afadin and PDZ-GEF2 to activate Rap1A, regulate beta1 integrin levels, and enhance cell migration. Mol Biol Cell. 2009;20(7):1916–25.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Suh PG, Park JI, Manzoli L, Cocco L, Peak JC, Katan M, et al. Multiple roles of phosphoinositide-specific phospholipase C isozymes. BMB Rep. 2008;41(6):415–34.

    Article  PubMed  CAS  Google Scholar 

  • Wang H, Singh SR, Zheng Z, Oh SW, Chen X, Edwards K, et al. Rap-GEF signaling controls stem cell anchoring to their niche through regulating DE-cadherin-mediated cell adhesion in the Drosophila testis. Dev Cell. 2006;10(1):117–26.

    Article  PubMed  CAS  Google Scholar 

  • Wennerberg K, Rossman KL, Der CJ. The Ras superfamily at a glance. J Cell Sci. 2005;118(Pt 5):843–6.

    Article  PubMed  CAS  Google Scholar 

  • Williams CL. A new signaling paradigm to control the prenylation and trafficking of small GTPases. Cell Cycle. 2013;12(18):2933–4.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Yaman E, Gasper R, Koerner C, Wittinghofer A, Tazebay UH. RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange. FEBS J. 2009;276(16):4607–16.

    Article  PubMed  CAS  Google Scholar 

  • Yoshikawa Y, Satoh T, Tamura T, Wei P, Bilasy SE, Edamatsu H, et al. The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes. Mol Biol Cell. 2007;18(8):2949–59.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Lawrence A. Quilliam .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Quilliam, L.A. (2018). Rap GEF Family. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_274

Download citation

Publish with us

Policies and ethics