Skip to main content

MLK3

  • Reference work entry
  • First Online:
Book cover Encyclopedia of Signaling Molecules

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 4,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 4,499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Chadee DN. Involvement of mixed lineage kinase 3 in cancer. Can J Physiol Pharmacol. 2013;91:268–74.

    Article  CAS  PubMed  Google Scholar 

  • Chen J, Miller EM, Gallo KA. MLK3 is critical for breast cancer cell migration and promotes a malignant phenotype in mammary epithelial cells. Oncogene. 2010;29:4399–411.

    Article  CAS  PubMed  Google Scholar 

  • Chen J, Gallo KA. MLK3 regulates paxillin phosphorylation in chemokine-mediated breast cancer cell migration and invasion to drive metastasis. Cancer Res. 2012;72:4130–40.

    Article  CAS  PubMed  Google Scholar 

  • Craige SM, Reif MM, Kant S. Mixed-lineage kinases (MLKs) in inflammation, metabolism, and other disease states. Biochim Biophs Acta – Mol Basis Dis. 2016;1862:1581–6.

    Article  CAS  Google Scholar 

  • Dhanasekaran DN, Kashef K, Lee CM, Xu H, Reddy EP. Scaffold proteins of MAP-kinase modules. Oncogene. 2007;26:3185–202.

    Article  CAS  PubMed  Google Scholar 

  • Eggert D, Dash PK, Gorantla S, Dou H, Schifitto G, Maggirwar SB, Dewhurst S, Poluektova L, Gelbard HA, Gendelman HE. Neuroprotective activities of CEP-1347 in models of neuroAIDS. J Immunol. 2010;184:746–56.

    Article  CAS  PubMed  Google Scholar 

  • Falsig J, Pörzgen P, Lotharius J, Leist M. Specific modulation of astrocyte inflammation by inhibition of mixed lineage kinases with CEP-1347. J Immunol. 2004;173:2762–70.

    Article  CAS  PubMed  Google Scholar 

  • Gallo KA, Johnson GL. Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol. 2002;3:663–72.

    Article  CAS  PubMed  Google Scholar 

  • Handley ME, Rasaiyaah J, Chain BM, Katz DR. Mixed lineage kinases (MLKs): a role in dendritic cells, inflammation and immunity? Int J Exp Pathol. 2007;88:111–26.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kyriakis JM. The integration of signaling by multiprotein complexes containing Raf kinases. Biochim Biophys Acta. 2007;1773:1238–47.

    Article  CAS  PubMed  Google Scholar 

  • Marker DF, Tremblay ME, Puccini JM, Barbieri J, Gantz Marker MA, Loweth CJ, Muly EC, Lu SM, Goodfellow VS, Dewhurst S, Gelbard HA. The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders. J Neurosci. 2013;33:9998–10010.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Mishra R, Barthwal MK, Sondarva G, Rana B, Wong L, Chatterjee M, Woodgett JR, Rana A. Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3. J Biol Chem. 2007;282:30393–405.

    Article  PubMed  CAS  Google Scholar 

  • Parkinson Study Group PRECEPT Investigators. Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease. Neurology. 2007;69:1480–90.

    Article  CAS  Google Scholar 

  • Rattanasinchai C, Gallo KA. MLK3 signaling in cancer invasion. Cancers. 2016;8(5):51. Review.

    Article  CAS  PubMed Central  Google Scholar 

  • Shintani Y, Fukumoto Y, Chaika N, Svoboda R, Wheelock MJ, Johnson KR. Collagen I-mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1. J Cell Biol. 2008;180:1277–89.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Swenson-Fields KI, Sandquist JC, Rossol-Allison J, Blat IC, Wennerberg K, Burridge K, Means AR. MLK3 limits activated Galphaq signaling to Rho by binding to p63RhoGEF. Mol Cell. 2008;32:43–56.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Velho S, Pinto A, Licasto D, Oliveira MJ, Sousa F, Stupka E, Seruca R. Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation. BMC Cancer. 2014;14:182.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wang LH, Besirli CG, Johnson Jr EM. Mixed-lineage kinases: a target for the prevention of neurodegeneration. Annu Rev Pharmacol Toxicol. 2004;44:451–74.

    Article  CAS  PubMed  Google Scholar 

  • Zhang Q-G, Wang R, Hana D, Dong Y, Branna DW. Role of Rac1 GTPase in JNK signaling and delayed neuronal cell death following global cerebral ischemia. Brain Res. 2009;1265:138–47.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Zhang G, Guo D, Dash PK, Arainga M, Wiederin JL, Haverland NA, Knibbe-Hollinger J, Martinez-Skinner A, Ciborowski P, Goodfellow VS, Wysocki TA, Wysocki BJ, Poluektova LY, Liu XM, McMillan JM, Gorantla S, Gelbard HA, Gendelman HE. The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy. Nanomedicine. 2016;12:109–22.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kathleen A. Gallo .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Rattanasinchai, C., Chen, J., Gallo, K.A. (2018). MLK3. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_247

Download citation

Publish with us

Policies and ethics