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MALT1(Mucosa-Associated Lymphoid Tissue Translocation Gene 1)

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References

  • Akagi T, Motegi M, Tamura A, Suzuki R, Hosokawa Y, Suzuki H, Ota H, Nakamura S, Morishima Y, Taniwaki M, Seto M. A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue. Oncogene. 1999;18(42):5785–94.

    Article  CAS  PubMed  Google Scholar 

  • Coornaert B, Baens M, Heyninck K, Bekaert T, Haegman M, Staal J, Sun L, Chen ZJ, Marynen P, Beyaert R. T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. Nat Immunol. 2008;9(3):263–71.

    Article  PubMed  CAS  Google Scholar 

  • Dierlamm J, Baens M, Wlodarska I, Stefanova-Ouzounova M, Hernandez JM, Hossfeld DK, De Wolf-Peeters C, Hagemeijer A, Van den Berghe H, Marynen P. The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas. Blood. 1999;93(11):3601–9.

    CAS  PubMed  Google Scholar 

  • Duwel M, Welteke V, Oeckinghaus A, Baens M, Kloo B, Ferch U, Darnay BG, Ruland J, Marynen P, Krappmann D. A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains. J Immunol. 2009;182(12):7718–28.

    Article  PubMed  CAS  Google Scholar 

  • Duwel M, Hadian K, Krappmann D. Ubiquitin conjugation and deconjugation in NF-kappaB signaling. Subcell Biochem. 2010;54:88–99.

    Article  PubMed  Google Scholar 

  • Ferch U, ZumBuschenfelde CM, Gewies A, Wegener E, Rauser S, Peschel C, Krappmann D, Ruland J. MALT1 directs B cell receptor-induced canonical nuclear factor-kappaB signaling selectively to the c-Rel subunit. Nat Immunol. 2007;8(9):984–91.

    Article  CAS  PubMed  Google Scholar 

  • Ferch U, Kloo B, Gewies A, Pfander V, Duwel M, Peschel C, Krappmann D, Ruland J. Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells. J Exp Med. 2009;206(11):2313–20.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gross O, Gewies A, Finger K, Schafer M, Sparwasser T, Peschel C, Forster I, Ruland J. Card9 controls a non-TLR signaling pathway for innate anti-fungal immunity. Nature. 2006;442(7103):651–6.

    Article  CAS  PubMed  Google Scholar 

  • Gross O, Grupp C, Steinberg C, Zimmermann S, Strasser D, Hannesschlager N, Reindl W, Jonsson H, Huo H, Littman DR, Peschel C, Yokoyama WM, Krug A, Ruland J. Multiple ITAM-coupled NK-cell receptors engage the Bcl10/Malt1 complex via Carma1 for NF-kappaB and MAPK activation to selectively control cytokine production. Blood. 2008;112(6):2421–8.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hailfinger S, Nogai H, Pelzer C, Jaworski M, Cabalzar K, Charton JE, Guzzardi M, Decaillet C, Grau M, Dorken B, Lenz P, Lenz G, Thome M. Malt1-dependent RelB cleavage promotes canonical NF-{kappa}B activation in lymphocytes and lymphoma cell lines. Proc Natl Acad Sci USA. 2012;108(35):14596–601.

    Article  Google Scholar 

  • Hara H, Saito T. CARD9 versus CARMA1 in innate and adaptive immunity. Trends Immunol. 2009;30(5):234–42.

    Article  PubMed  CAS  Google Scholar 

  • Jost PJ, Weiss S, Ferch U, Gross O, Mak TW, Peschel C, Ruland J. Bcl10/Malt1 signaling is essential for TCR-induced NF-kappaB activation in thymocytes but dispensable for positive or negative selection. J Immunol. 2007;178(2):953–60.

    Article  CAS  PubMed  Google Scholar 

  • Kawadler H, Gantz MA, Riley JL, Yang X. The paracaspase MALT1 controls caspase-8 activation during lymphocyte proliferation. Mol Cell. 2008;31(3):415–21.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Klemm S, Ruland J. Inflammatory signal transduction from the Fc epsilon RI to NF-kappa B. Immunobiology. 2006;10:815–20.

    Article  CAS  Google Scholar 

  • Klemm S, Gutermuth J, Hultner L, Sparwasser T, Behrendt H, Peschel C, Mak TW, Jakob T, Ruland J. The Bcl10-Malt1 complex segregates Fc epsilon RI-mediated nuclear factor kappa B activation and cytokine production from mast cell degranulation. J Exp Med. 2006;203(2):337–47.

    Article  PubMed  PubMed Central  Google Scholar 

  • Klemm S, Zimmermann S, Peschel C, Mak TW, Ruland J. Bcl10 and Malt1 control lysophosphatidic acid-induced NF-kappaB activation and cytokine production. Proc Natl Acad Sci USA. 2007;104(1):134–8.

    Article  CAS  PubMed  Google Scholar 

  • Mocsai A, Ruland J, Tybulewicz VL. The SYK tyrosine kinase: a crucial player in diverse biological functions. Nat Rev Immunol. 2010;10(6):387–402.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Oeckinghaus A, Wegener E, Welteke V, Ferch U, Arslan SC, Ruland J, Scheidereit C, Krappmann D. Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation. EMBO J. 2007;26(22):4634–45.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Rebeaud F, Hailfinger S, Posevitz-Fejfar A, Tapernoux M, Moser R, Rueda D, Gaide O, Guzzardi M, Iancu EM, Rufer N, Fasel N, Thome M. The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nat Immunol. 2008;9(3):272–81.

    Article  CAS  PubMed  Google Scholar 

  • Rosebeck S, Madden L, Jin X, Gu S, Apel IJ, Appert A, Hamoudi RA, Noels H, Sagaert X, Van Loo P, Baens M, MQ D, Lucas PC, McAllister-Lucas LM. Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation. Science. 2012;331(6016):468–72.

    Article  CAS  Google Scholar 

  • Ruefli-Brasse AA, French DM, Dixit VM. Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase. Science. 2003;302(5650):1581–4.

    Article  PubMed  CAS  Google Scholar 

  • Ruland J, Duncan GS, Elia A, del Barco Barrantes I, Nguyen L, Plyte S, Millar DG, Bouchard D, Wakeham A, Ohashi PS, Mak TW. Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Cell. 2001;104(1):33–42.

    Article  PubMed  CAS  Google Scholar 

  • Ruland J, Duncan GS, Wakeham A, Mak TW. Differential requirement for Malt1 in T and B cell antigen receptor signaling. Immunity. 2003;19(5):749–58.

    Article  PubMed  CAS  Google Scholar 

  • Schoenen H, Bodendorfer B, Hitchens K, Manzanero S, Werninghaus K, Nimmerjahn F, Agger EM, Stenger S, Andersen P, Ruland J, Brown GD, Wells C, Lang R. Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate. J Immunol. 2010;184(6):2756–60.

    Article  PubMed  CAS  Google Scholar 

  • Staal J, Driege Y, Bekaert T, Demeyer A, Muyllaert D, Van Damme P, Gevaert K, Beyaert R. T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1. EMBO J. 2012;30(9):1742–52.

    Article  CAS  Google Scholar 

  • Sun L, Deng L, Ea CK, Xia ZP, Chen ZJ. The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol Cell. 2004;14(3):289–301.

    Article  CAS  PubMed  Google Scholar 

  • Thome M, Charton JE, Pelzer C, Hailfinger S. Antigen receptor signaling to NF-kappaB via CARMA1, BCL10, and MALT1. Cold Spring Harb Perspect Biol. 2010;2(9):a003004.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Tusche MW, Ward LA, Vu F, McCarthy D, Quintela-Fandino M, Ruland J, Gommerman JL, Mak TW. Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets. J Exp Med. 2009;206(12):2671–83.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Uren AG, O’Rourke K, Aravind LA, Pisabarro MT, Seshagiri S, Koonin EV, Dixit VM. Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. Mol Cell. 2000;6(4):961–7.

    CAS  PubMed  Google Scholar 

  • Xue L, Morris SW, Orihuela C, Tuomanen E, Cui X, Wen R, Wang D. Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells. Nat Immunol. 2003;4(9):857–65.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

We thank Frank Oliver Gorka for thoughtfully reading and discussing the manuscript.

Author information

Authors and Affiliations

  1. Laboratory for Signaling in the Immune System, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany

    Andreas Gewies & Jürgen Ruland

  2. Third Medical Department, Institute for Molecular Immunology, Technical University of Munich, Klinikum rechts der Isar, Klinikum rechts der Isar, Ismaninger St. 22, Munich, 81675, Germany

    Jürgen Ruland

Authors
  1. Andreas Gewies
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  2. Jürgen Ruland
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Corresponding author

Correspondence to Andreas Gewies .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Gewies, A., Ruland, J. (2018). MALT1(Mucosa-Associated Lymphoid Tissue Translocation Gene 1). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_234

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