Synonyms
Historical Background
Ras superfamily small GTP (guanosine triphosphate)-binding proteins function as molecular switches, responding to extra- and intracellular stimuli to control the activity of diverse signaling cascades. To date, over 150 different small GTPases have been identified and are classified into six distinct subfamilies – Ras (Rat sarcoma), Rho (Ras homolog gene family), Rab (Ras-related GTP- binding protein), ARF (ADP- ribosylation factor), Ran (Ras-related nuclear protein), and RGK (Rad/Gem/Kir family) – based upon both sequence homology and the regulation of common cellular functions (Colicelli 2004). Rin (Ras-like protein in neurons), along with Rit (Ras-like protein in many tissues) and Drosophila Ric (Ras-related protein which interacted with calmodulin), comprise the Rit subfamily of Ras-related small GTPases (Lee et al. 1996). Rin is expressed exclusively within neurons, including RGCs (retinal ganglion cells)...
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Acknowledgments
This work was supported by Public Health Service grant NS045103 from the National Institute of Neurological Disorders and Stroke and 14-1 from the Kentucky Spinal Cord and Head Injury Research Trust.
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Rudolph, J.L., Andres, D.A., Cai, W. (2018). Rin (Ras-Like Protein in Neurons). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_122
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DOI: https://doi.org/10.1007/978-3-319-67199-4_122
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