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BUBR1

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 164 Accesses

Synonyms

Bub1A; BUB1beta; hBUBR1; MAD3L; MVA1; SSK1

Related Molecules

APC; BUB1; CDC25; PP2A.

Historical Background

The BUB1B gene encodes the protein budding uninhibited by benzimidazole-related 1 (BUBR1), a vital mitotic pseudokinase of the Spindle Assembly Checkpoint (SAC). This signaling pathway is responsible for delaying anaphase onset until all chromosome are properly attached to microtubules originating from opposing poles of the mitotic spindle, and prevents errors in chromosome segregation, which can lead to aneuploidy and chromosome instability, a pathogenic state with the potential to drive oncogenesis (Holland and Cleveland 2009; Kops et al. 2005).

Human BUBR1 was discovered through sequence-database searches in a study that aimed to identify the relationship between chromosomal instability, the SAC, and neoplasia (Cahill et al. 1998). BUBR1 is considered to be the human homolog of yeast Mitotic Arrest Deficient (MAD) 3 protein, although it was first thought to be the...

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Authors and Affiliations

  1. Programme in Cellular and Molecular Biology, Faculty of Medicine, Université Laval, Ferdinand Vander pavillion, 1050 Ave de ca medicine, Québec, QC, G1V 0A6, Canada

    Luciano Gama Braga

  2. Axe of Reproduction, Mother and Youth Health, Centre de recherche du Centre Hospitalier Universitairé de Quebec, Québec, QC, G1V 4G2, Canada

    Sabine Elowe

  3. The Department of Pediatrics, Faculty of Medicine, Université Laval, Québec City, QC, G1V 4G2, Canada

    Sabine Elowe

Authors
  1. Luciano Gama Braga
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  2. Sabine Elowe
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Correspondence to Sabine Elowe .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Braga, L.G., Elowe, S. (2018). BUBR1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101975

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