Historical Background
The thyrotropin receptor (TSHR) is a seven-transmembrane protein that belongs to the family of G-protein-coupled receptors (GPCR). The receptor is located on the surface of thyroid follicular cells, and its activation leads to thyroid hormone production and growth and proliferation of thyrocytes.
The primary activator of the TSHR is the thyroid-stimulating hormone (TSH) or thyrotropin, although the receptor may also be activated by stimulating antibodies as occurs in autoimmune hyperthyroidism, known as Graves’ disease. The TSHR is expressed in many non-thyroidal tissues and may be involved in the systemic manifestations of thyroid disease, such as thyroid-associated ophthalmopathy, pretibial myxedema, and metabolic bone disease.
Structurally, the TSHR can be...
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El-Kaissi, S. (2018). Thyrotropin Receptor. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101925
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101925
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