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Encyclopedia of Signaling Molecules pp 109–116Cite as

ACSL4

  • Reference work entry
  • First Online:

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Synonyms

ACS4; Acyl-CoA synthetase long-chain family member 4; FACL4; LACS4; MRX63; MRX68

Historical Background

The acyl-CoA synthetases (ACS) are enzymes that catalyze the production of acyl-CoA from fatty acids. The length of the carbon chain of the fatty acid species defines the substrate specificity for the different ACS.

The presence of an ACS specific for arachidonate had been shown by enzymatic characterizations in 1985 (Laposata et al. 1985), and later the primary structure, enzymatic properties, and tissue expression of this newly identified ACS enzyme, designated ACS4 (later named ACSL4), were described by Kang et al. (1997). It belongs to the large family of mammalian long-chain acyl-CoA synthetases (ACSL), which activate fatty acids with chain lengths of 12–20 carbon atoms. The human and mouse genes for the ACSLs are termed ACSL1,3-6 and Acsl1,3-6, respectively. Each isoform has a substrate preference, subcellular localization, and tissue distribution and has been...

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Authors and Affiliations

  1. Instituto de Investigaciones Biomédicas (INBIOMED) UBA-CONICET; Departamento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina

    Paula M. Maloberti, Ana F. Castillo, Ulises Orlando & Ernesto J. Podesta

Authors
  1. Paula M. Maloberti
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  2. Ana F. Castillo
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  3. Ulises Orlando
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  4. Ernesto J. Podesta
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Corresponding authors

Correspondence to Paula M. Maloberti or Ana F. Castillo .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Maloberti, P.M., Castillo, A.F., Orlando, U., Podesta, E.J. (2018). ACSL4. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101897

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