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AMP-Activated Protein Kinase (AMPK)

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Encyclopedia of Signaling Molecules

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Synonyms

Adenosine monophosphate-activated protein kinase; AMPK (AMP-activated protein kinase); HMG-CoA reductase kinase (3-hydroxy-3-methylglutaryl-coenzyme A reductase); STK29

Historical Background

AMPK (5′ adenosine monophosphate-activated protein kinase) (EC; 2.7.11.31) is a cellular energy sensor that is activated by increased intracellular levels of AMP or ADP produced as a result of unrestrained ATP hydrolysis, thus representing scarcity of cellular ATP. AMPK, therefore, allows adaptation to low energy conditions to preserve the cellular energy homeostasis and in response increases catabolism to generate more ATP. Besides acting as a sensor for intracellular metabolic stress signals, due to nutritional insufficiency and hypoxia, AMPK also gets activated by an array of physiological stimulations, including calcium concentration via calmodulin kinase (CAMKKβ), action of various hormones, and cytokines. In brief, once activated by sensing the falling energy (ATP) status, it...

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Authors and Affiliations

  1. National Center for Applied Human Genetics, School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India

    Gopinath Prakasam, Mohammad Askandar Iqbal, Rajnish Kumar Singh & Rameshwar N. K. Bamezai

  2. Department of Biotechnology, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi, 110025, India

    Mohammad Askandar Iqbal

  3. Department of Microbiology and Tumor Virology Program of the Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Rajnish Kumar Singh

Authors
  1. Gopinath Prakasam
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  2. Mohammad Askandar Iqbal
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  3. Rajnish Kumar Singh
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  4. Rameshwar N. K. Bamezai
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Corresponding author

Correspondence to Rameshwar N. K. Bamezai .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Prakasam, G., Iqbal, M.A., Singh, R.K., Bamezai, R.N.K. (2018). AMP-Activated Protein Kinase (AMPK). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101894

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