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B Lymphocyte Antigen CD19

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  • First Online:
Encyclopedia of Signaling Molecules

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Synonyms

B4; CD19 molecule; CVID3

Historical Background

CD19 was first identified as biomarker of normal and neoplastic B lymphocytes as B4 antigen with the use of anti-B4 monoclonal antibody against CD19 (Anderson et al. 1984). Anti-B4 antibody in turn was encoded from cDNA clones of human tonsillar cDNA library, by selectively hybridizing with RNA from CD19+ cell lines. Both human and mouse CD19 molecules are highly homologous with a conserved cytoplasmic domain with no homology with other known proteins and an immunoglobulin-like extracellular domain, which gave CD19 molecule the status of a member of Ig superfamily (Tedder and Isaacs 1989).

Introduction

The CD19 molecule is a 95 KDa cell surface protein of B lymphocytes and follicular dendritic cells (FDC). It is considered as a biomarker of B cell because of its continued expression throughout B cell differentiation stages starting from late pro-B cell stage until terminally differentiated plasma cells (Nadler et al. 1983;...

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Authors and Affiliations

  1. Nanomaterial Therapeutics and Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan 31, Mahatma Gandhi Marg, 80, 226001, Lucknow, Uttar Pradesh, India

    Rashmi Kumar

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  1. Rashmi Kumar
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Correspondence to Rashmi Kumar .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Kumar, R. (2018). B Lymphocyte Antigen CD19. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101837

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