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Encyclopedia of Signaling Molecules pp 4069–4077Cite as

Platelet-Activating Factor Acetylhydrolase (Pafah)

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Synonyms

Lipoprotein-associated phospholipase A2 (Lp-PLA2); Phospholipase A2 group 7 (PLA2G7); Phospholipase A2 group 8 (PLA2G8)

Historical Background

Platelet activating factor-acetylhydrolases (PAF-AH) (EC 3.1.1.47) are essentially phospholipase A2 isoenzymes (Group VII and VIII) catalyzing the hydrolysis of short chain acyl group at the second position of phospholipids. An important bioactive lipid that led to the discovery of PAF-AH is platelet-activating factor (PAF), a potent proinflammatory lipid, whose discovery in the early 1970s was a breakthrough that opened a new dimension to the role of phospholipids, until then they were only considered as structural constituents of biological membranes/lipoproteins or at the most precursor for the biologically active phosphoinositides and eicosanoids (Hanahan 1986; Prescott et al. 2000). In 1970, Henson and colleagues (Henson 1970) first proposed the presence of a fluid phase mediator released by sensitized rabbit leukocytes capable of...

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Authors and Affiliations

  1. Department of Studies in Biochemistry, University of Mysore, Manasagangothri, Mysuru, 570 006, India

    Gopal Kedihithlu Marathe, Shancy Petsel Jacob, Mosale Seetharam Sumanth, Chikkamenahalli Lakshminarayana Lakshmikanth, Kandahalli Venkataranganayaka Abhilash & Vyala Hanumanthareddy Chaithra

Authors
  1. Gopal Kedihithlu Marathe
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  2. Shancy Petsel Jacob
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  3. Mosale Seetharam Sumanth
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  4. Chikkamenahalli Lakshminarayana Lakshmikanth
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  5. Kandahalli Venkataranganayaka Abhilash
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  6. Vyala Hanumanthareddy Chaithra
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Corresponding author

Correspondence to Gopal Kedihithlu Marathe .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Marathe, G.K., Jacob, S.P., Sumanth, M.S., Lakshmikanth, C.L., Abhilash, K.V., Chaithra, V.H. (2018). Platelet-Activating Factor Acetylhydrolase (Pafah). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101737

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