Synonyms
Historical Background
The discovery of ICAM-5 was made by K. Mori and colleagues in 1987. Mice were immunized with the synaptic fractions of olfactory bulb neurons and a series of monoclonal antibodies was generated. One of the antibodies showed immunoreactivity exclusively with the telencephalon (Mori et al. 1987). The target molecule was named telencephalin. Further analysis with this antibody showed a somatodendritic distribution, specific to neuronal membranes. The expression was found to be developmentally regulated.
By affinity chromatography, telencephalin was characterized as a 500 kDa glycoprotein consisting of four monomers. In subsequent studies, the target cDNA was generated and considerable homology to the intercellular adhesion molecule, ICAM, family found (Yoshihara et al. 1994). Telencephalin was included as the fifth and so far the youngest member of the family. Consistent with the nomenclature, it was renamed ICAM-5 (Gahmberg 1997...
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Annaert WG, Esselens C, Baert V, Boeve C, Snellings G, Cupers P, et al. Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins. Neuron. 2001;32(4):579–89.
Conant K, Lonskaya I, Szklarczyk A, Krall C, Steiner J, Maguire-Zeiss K, et al. Methamphetamine-associated cleavage of the synaptic adhesion molecule intercellular adhesion molecule-5. J Neurochem. 2011;118(4):521–32.
Conant K, Wang Y, Szklarczyk A, Dudak A, Mattson MP, Lim ST. Matrix metalloproteinase-dependent shedding of intercellular adhesion molecule-5 occurs with long-term potentiation. Neuroscience. 2010;166(2):508–21.
Furutani Y, Kawasaki M, Matsuno H, Mitsui S, Mori K, Yoshihara Y. Vitronectin induces phosphorylation of ezrin/radixin/moesin actin-binding proteins through binding to its novel neuronal receptor telencephalin. J Biol Chem. 2012;287(46):39041–9.
Gahmberg CG. Leukocyte adhesion: CD11/CD18 integrins and intercellular adhesion molecules. Curr Opin Cell Biol. 1997;9(5):643–50.
Matsuno H, Okabe S, Mishina M, Yanagida T, Mori K, Yoshihara Y. Telencephalin slows spine maturation. J Neurosci. 2006;26(6):1776–86.
Mitsui S, Saito M, Hayashi K, Mori K, Yoshihara Y. A novel phenylalanine-based targeting signal directs telencephalin to neuronal dendrites. J Neurosci. 2005;25(5):1122–31.
Mori K, Fujita SC, Watanabe Y, Obata K, Hayaishi O. Telencephalon-specific antigen identified by monoclonal antibody. Proc Natl Acad Sci U S A. 1987;84(11):3921–5.
Ning L, Paetau S, Nyman-Huttunen H, Tian L, Gahmberg CG. ICAM-5 affects spine maturation by regulation of NMDA receptor binding to α-actinin. Biol Open. 2015;4(2):125–36.
Ning L, Tian L, Smirnov S. Interactions between intercellular adhesion molecule-5 (ICAM-5) and b1 integrins regulate neuronal synapse formation. J Cell Sci. 2013;126(1):77–89.
Ohgomori T, Nanao T, Morita A, Ikekita M. Asn54-linked glycan is critical for functional folding of intercellular adhesion molecule-5. Glycoconj J. 2012;29(1):47–55.
Raemaekers T, Peric A, Baatsen P, Sannerud R, Declerck I, Baert V, et al. ARF6-mediated endosomal transport of Telencephalin affects dendritic filopodia-to-spine maturation. EMBO J. 2012;31(15):3252–69.
Recacha R, Jiménez D, Tian L, Barredo R, Gahmberg CG, Casasnovas JM. Crystal structures of an ICAM-5 ectodomain fragment show electrostatic-based homophilic adhesions. Acta Crystallogr D Biol Crystallogr. 2014;70(Pt 7):1934–43.
Tian L, Lappalainen J, Autero M, Hanninen S, Rauvala H, Gahmberg CG. Shedded neuronal ICAM-5 suppresses T-cell activation. Blood. 2008;111(7):3615–25.
Tian L, Nyman H, Kilgannon P, Yoshihara Y, Mori K, Andersson LC, et al. Intercellular adhesion molecule-5 induces dendritic outgrowth by homophilic adhesion. J Cell Biol. 2000;150(1):243–52.
Tian L, Stefanidakis M, Ning L, Van Lint P, Nyman-Huttunen H, Libert C, et al. Activation of NMDA receptors promotes dendritic spine development through MMP-mediated ICAM-5 cleavage. J Cell Biol. 2007;178(4):687–700.
Tse MCL, Lane C, Mott K, Onlamoon N, Hsiao HM, Perng GC. ICAM-5 modulates cytokine/chemokine production in the CNS during the course of herpes simplex virus type 1 infection. J Neuroimmunol. 2009;213(1–2):12–9.
Yang H, Wu D, Zhang X, Wang X, Peng Y, Hu Z. Telencephalin protects PAJU cells from amyloid beta protein-induced apoptosis by activating the ezrin/radixin/moesin protein family/phosphatidylinositol-3-kinase/protein kinase B pathway. Neural Regen Res. 2012;7(28):2189–98.
Yoshihara Y, Oka S, Nemoto Y, Watanabe Y, Nagata S, Kagamiyama H, et al. An ICAM-related neuronal glycoprotein, telencephalin, with brain segment-specific expression. Neuron. 1994;12(3):541–53.
Zhang H, Casasnovas JM, Jin M, Liu JH, Gahmberg CG, Springer TA, et al. An unusual allosteric mobility of the C-terminal helix of a high-affinity alphaL integrin I domain variant bound to ICAM-5. Mol Cell. 2008;31(3):432–7.
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Paetau, S., Gahmberg, C.G. (2018). Intercellular Adhesion Molecule-5. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101656
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101656
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