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References
Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett. 2003;554(3):381–8.
Gong Z, Yoshimura M, Aizawa S. G protein-coupled receptor 120 signaling regulates ghrelin secretion in vivo and in vitro. Am J Physiol Endocrinol Metab. 2014;306(1):E28–35.
Hirasawa A, Tsumaya K, Awaji T, Katsuma S, Adachi T, et al. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat Med. 2005;11:90–4.
Hudson BD, Shimpukade B, Mackenzie AE, Butcher AJ, Pediani JD, et al. The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism. Mol Pharmacol. 2013;84:710–25.
Ichimura A, Hirasawa A, Godefroy OP, et al. Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature. 2012;483:350–4.
Kazakos K. Incretin effect: GLP-1, GIP, DPP4. Diabetes Res Clin Pract. 2011;93:S32–6.
Kroeze WK, Sheffler DJ, Roth BL. G-protein-coupled receptors at a glance. J Cell Sci. 2003;116:4867–9.
Marzuillo P, Grandone A, Conte M, Capuano F, Cirillo G, et al. Novel association between a nonsynonymous variant (R270H) of the G-protein-coupled receptor 120 and liver injury in children and adolescents with obesity. J Pediatr Gastroenterol Nutr. 2014;59:472–5.
Miyauchi S, Hirasawa A, Iga T, Liu N, Itsubo C, et al. Distribution and regulation of protein expression of the free fatty acid receptor GPR120. Naunyn Schmiedeberg's Arch Pharmacol. 2009;379:427–34.
Mobraten K, Haug TM, Kleiveland CR, et al. Omega-3 and omega-6 PUFAs induce the same GPR120-mediated signalling events, but with different kinetics and intensity in Caco-2 cells. Lipids Health Dis. 2013;12:101.
Oh DY, Talukdar S, Bae EJ, et al. GPR120 is an ω-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell. 2010;142:687–98.
Oh DY, Walenta E, Akiyama TE, et al. A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. Nat Med. 2014;20:942–7.
Ozdener MH, Subramaniam S, Sundaresan S, Sery O, Hashimoto T, et al. CD36- and GPR120-mediated Ca2+signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice. Gastroenterology. 2014;146:995–1005.
Raptis DA, Limani P, Jang JH, Ungethum U, Tschuor C, et al. GPR120 on Kupffer cells mediates hepatoprotective effects of ω3-fatty acids. J Hepatol. 2014;60:625–32.
Talukdar S, Olefsky JM, Osborn O. Targeting GPR120 and other fatty acid sensing GPCRs ameliorates insulin resistance and inflammatory diseases. Trends Pharmacol Sci. 2011;32(9):543–50.
Tanaka T, Katsuma S, Adachi T, Koshimizu TA, Hirasawa A, Tsujimoto G. Free fatty acids induce cholecystokinin secretion through GPR120. Naunyn Schmiedeberg's Arch Pharmacol. 2008;377:523–7.
Taneera J, Lang S, Sharma A, Fadista J, Zhou Y, et al. A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets. Cell Metab. 2012;16:122–34.
Watterson KR, Hudson BD, Ulven T, Milligan G. Treatment of type 2 diabetes by free fatty acid receptor agonists. Front Endocrinol. 2014;5:137.
Yan Y, Jiang W, Spinetti T, Tardivel A, et al. Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity. 2013;38(6):1154–63.
Zhang D, So WY, Wang Y, Wu SY, Cheng Q, Leung PS. Insulinotropic effects of GPR120 agonists are altered in obese non-diabetic and diabetic states. Clin Sci. 2016;131:247–60.
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Wang, Y., Leung, P.S. (2018). GPR120. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101625
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101625
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