Synonyms
cAMP-GEFI; cAMP-GEFII; cAMP-regulated guanine nucleotide exchange factor; Exchange factor directly activated by cAMP; Exchange protein directly activated by cAMP (Epac); Exchange protein directly activated by cAMP 1 (Epac1); Exchange protein directly activated by cAMP 2 (Epac2); Rap guanine-nucleotide exchange factor (GEF); Rap guanine nucleotide exchange factor 3 (Rapgef3); Rap guanine nucleotide exchange factor 4 (Rapgef4); Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
Historical Background
Eukaryotic cells respond to a wide range of extracellular signals such as growth factors, hormones, and neurotransmitters through the generation of intracellular second messengers. One of the most studied second messenger, cyclic adenosine 3′–5′-monophosphate (cAMP), regulates many cellular events, including secretion, differentiation, migration, and apoptosis. cAMP is produced from adenosine triphosphate (ATP) by adenylyl cyclase (AC) in response to Gαs-coupled G...
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Acknowledgments
F. Lezoualc’h was supported by grants from Institut National de la Santé et de la Recherche Médicale, Fondation pour la Recherche Médicale (Programme “Equipes FRM 2016”, DEQ20160334892), Fondation de France (00066331) and Université de Toulouse.
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Conte, C., Lezoualc’h, F. (2018). Epac. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101595
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101595
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