Synonyms
Historical Background
Calreticulin was discovered in the early 1970s as a high affinity calcium-binding protein (HACBP) of the sarcoplasmic reticulum (Ostwald and MacLennan 1974). Later, based on N-terminal amino acid sequence analysis and molecular cloning of cDNA encoding calreticulin, it was realized that the protein was identical to calregulin, CRP55, CaBP3, ERp60, and calsequestrin-like protein (Michalak et al. 2009). The name “calreticulin” is now universally accepted to reflect the protein’s Ca2+binding capacity and localization in the sarcoplasmic/endoplasmic reticulum (ER). Calreticulin is a ubiquitous protein that is present in all eukaryotic cells except for erythrocytes, as these cells lack ER. There is reduced abundance of calreticulin in differentiated tissues (heart and brain), while highly...
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References
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Dudek, E., Michalak, M. (2018). Calreticulin. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101570
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101570
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