Synonyms
Historical Background
In 1998 the De Camilli Lab (Yale University) isolated a novel protein able to bind the endocytic protein eps15 from rat brain extracts and accordingly named it as Eps15 interacting protein 1, Epsin-1 or just Epn1 (Fig. 1 and Chen et al. 1998). Conservation of Epn1 was evident as sequence comparison revealed homology to the mitotic phosphoprotein-90 from Xenopus laevis and to the Ent1 and Ent2 yeast proteins. The Epn1 paralog, Epn2, was also discovered by the De Camilli Lab the following year (Rosenthal et al. 1999) which along with Epn1 was found localized at the plasma membrane and to participate in clathrin-mediated endocytosis (Sen et al. 2012; Wendland 2002). While these Epn paralogs showed widespread expression with substantial enrichment in the brain, a later described third paralog named epsin-3 was found to be virtually restricted to keratinocytes, gastric parietal cells, and several carcinomas (Sen et al. 2012).
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Acknowledgments
I thank the members of the Aguilar Lab for input. I apologize to all authors whose original contributions we could not cite due to space limitations. For more complete listings, please refer to the cited reviews and references therein. The Aguilar Lab is supported by grants from the National Science Foundation MCB-1021377 and by the Center for Science of Information (CSoI), an NSF Science and Technology Center, under grant agreement CCF-0939370.
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Aguilar, R.C. (2018). Epsin. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101568
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101568
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