Historical Background
Chemokines are small chemotactic cytokines that promote directional cell movement and originally were shown to regulate inflammation. By now the superfamily of chemokines and their receptors consists of 50 chemokines and 19 receptors (Zlotnik et al. 2006). Chemokines are classified into four groups CC, CXC, C, and CX3C, based on the position of the conserved cysteines in the amino-terminal domain. They bind to G-coupled protein receptors, with one ligand usually binding to more than one receptor and with the receptors exhibiting high affinity for more than one ligand (Rollins 1997). The chemokine superfamily is characterized, besides the low molecular mass (8–10 kDa) and the four conserved cysteines, by the ability of its members to bind heparin. The major chemokine clusters are the CC and the CXC, with the first originally identified as chemoattractant for monocytes and the latter for neutrophils. The CC and...
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Bonapace L, Coissieux MM, Wyckoff J, et al. Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis. Nature. 2014;515:130–3.
Bottazzi B, Colotta F, Sica A, Nobili N, Mantovani A. A chemoattractant expressed in human sarcoma cells (tumor-derived chemotactic factor, TDCF) is identical to monocyte chemoattractant protein-1/monocyte chemotactic and activating factor (MCP-1/MCAF). Int J Cancer. 1990;45:795–7.
Cho YB, Lee WY, Choi SJ, et al. CC chemokine ligand 7 expression in liver metastasis of colorectal cancer. Oncol Rep. 2012;28:689–94.
Das S, Sarrou E, Podgrabinska S, et al. Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses. J Exp Med. 2013;210:1509–28.
Dimitrijevic OB, Stamatovic SM, Keep RF, Andjelkovic AV. Absence of the chemokine receptor CCR2 protects against cerebral ischemia/reperfusion injury in mice. Stroke. 2007;38:1345–53.
Farmaki E, Chatzistamou I, Kaza V, Kiaris H. A CCL8 gradient drives breast cancer cell dissemination. Oncogene. 2016;35:6309–18.
Fujimoto H, Sangai T, Ishii G, et al. Stromal MCP-1 in mammary tumors induces tumor-associated macrophage infiltration and contributes to tumor progression. Int J Cancer. 2009;125:1276–84.
Halvorsen EC, Hamilton MJ, Young A, et al. Maraviroc decreases CCL8-mediated migration of CCR5(+) regulatory T cells and reduces metastatic tumor growth in the lungs. Oncoimmunology. 2016;5:e1150398.
Heidegger I, Hofer J, Luger M, et al. Is Eotaxin-1 a serum and urinary biomarker for prostate cancer detection and recurrence? Prostate. 2015;75:1904–9.
Islam SA, Chang DS, Colvin RA, et al. Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells. Nat Immunol. 2011;12:167–77.
Jose PJ, Griffiths-Johnson DA, Collins PD, et al. Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. J Exp Med. 1994;179:881–7.
Kalayci O, Sonna LA, Woodruff PG, Camargo Jr CA, Luster AD, Lilly CM. Monocyte chemotactic protein-4 (MCP-4; CCL-13): a biomarker of asthma. J Asthma. 2004;41:27–33.
Lu X, Kang Y. Chemokine (C-C motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone. J Biol Chem. 2009;284:29087–96.
Maddaluno M, Di Lauro M, Di Pascale A, et al. Monocyte chemotactic protein-3 induces human coronary smooth muscle cell proliferation. Atherosclerosis. 2011;217:113–9.
McCully ML, Moser B. The human cutaneous chemokine system. Front Immunol. 2011;2:33.
Nomiyama H, Mera A, Ohneda O, Miura R, Suda T, Yoshie O. Organization of the chemokine genes in the human and mouse major clusters of CC and CXC chemokines: diversification between the two species. Genes Immun. 2001;2:110–3.
Proost P, Wuyts A, Van Damme J. Human monocyte chemotactic proteins-2 and -3: structural and functional comparison with MCP-1. J Leukoc Biol. 1996;59:67–74.
Rollins BJ, Sunday ME. Suppression of tumor formation in vivo by expression of the JE gene in malignant cells. Mol Cell Biol. 1991;11:3125–31.
Rollins BJ. Chemokines. Blood. 1997;90:909–28.
Ruffing N, Sullivan N, Sharmeen L, Sodroski J, Wu L. CCR5 has an expanded ligand-binding repertoire and is the primary receptor used by MCP-2 on activated T cells. Cell Immunol. 1998;189:160–8.
Ruhwald M, Bodmer T, Maier C, et al. Evaluating the potential of IP-10 and MCP-2 as biomarkers for the diagnosis of tuberculosis. Eur Respir J. 2008;32:1607–15.
Schenk S, Mal N, Finan A, et al. Monocyte chemotactic protein-3 is a myocardial mesenchymal stem cell homing factor. Stem Cells. 2007;25:245–51.
Schweickart VL, Epp A, Raport CJ, Gray PW. CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines. J Biol Chem. 2000;275:9550–6.
Song LY, Kim SY, Song SJ, et al. Crosstalk between CCL7 and CCR3 promotes metastasis of colon cancer cells via ERK-JNK signaling pathways. Oncotarget. 2016;7:36842–53.
Sozzani S, Zhou D, Locati M, et al. Receptors and transduction pathways for monocyte chemotactic protein-2 and monocyte chemotactic protein-3. Similarities and differences with MCP-1. J Immunol. 1994;152:3615–22.
Tian M, Chen L, Li M, et al. Expression and prognostic significance of CCL11/CCR3 in glioblastoma. Oncotarget. 2016;7:32617–27.
Ueno T, Toi M, Saji H, et al. Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer. Clin Cancer Res. 2000;6:3282–9.
Uguccioni M, Loetscher P, Forssmann U, et al. Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin. J Exp Med. 1996;183:2379–84.
Wang JM, Chertov O, Proost P, et al. Purification and identification of chemokines potentially involved in kidney-specific metastasis by a murine lymphoma variant: induction of migration and NFkappaB activation. Int J Cancer. 1998;75:900–7.
Yadav A, Saini V, Arora S. MCP-1: Chemoattractant with a role beyond immunity: a review. Clin Chim Acta. 2010;411:1570–9.
Yamaguchi A, Nozawa K, Fujishiro M, et al. CC motif chemokine ligand 13 is associated with rheumatoid arthritis pathogenesis. Mod Rheumatol. 2013;23:856–63.
Yamamoto M, Ota A, Hori T, et al. Early expression of plasma CCL8 closely correlates with survival rate of acute graft-vs.-host disease in mice. Exp Hematol. 2011;39:1101–12.
Yanaba K, Yoshizaki A, Muroi E, et al. CCL13 is a promising diagnostic marker for systemic sclerosis. Br J Dermatol. 2010;162:332–6.
Yang OO, Garcia-Zepeda EA, Walker BD, Luster AD. Monocyte chemoattractant protein-2 (CC chemokine ligand 8) inhibits replication of human immunodeficiency virus type 1 via CC chemokine receptor 5. J Infect Dis. 2002;185:1174–8.
Yeh CR, Hsu I, Song W, et al. Fibroblast ERalpha promotes bladder cancer invasion via increasing the CCL1 and IL-6 signals in the tumor microenvironment. Am J Cancer Res. 2015;5:1146–57.
Zlotnik A, Yoshie O, Nomiyama H. The chemokine and chemokine receptor superfamilies and their molecular evolution. Genome Biol. 2006;7:243.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer International Publishing AG
About this entry
Cite this entry
Farmaki, E., Chatzistamou, I., Kiaris, H. (2018). Human MCP Chemokine Cluster. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101562
Download citation
DOI: https://doi.org/10.1007/978-3-319-67199-4_101562
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-67198-7
Online ISBN: 978-3-319-67199-4
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences