Carolina Camelo and Catarina Peneda contributed equally to this work.
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References
Bartolini F, Bhamidipati A, Thomas S, Schwahn U, Lewis SA, Cowan NJ. Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C. J Biol Chem. 2002;277:14629–34. https://doi.org/10.1074/jbc.M200128200.
Carranza G, Castano R, Fanarraga ML, Villegas JC, Gonçalves J, Soares H, et al. Autoinhibition of TBCB regulates EB1-mediated microtubule dynamics. Cell Mol Life Sci. 2013;70:357–71. https://doi.org/10.1007/s00018-012-1114-2.
Downing KH, Nogales E. Tubulin structure: insights into microtubule properties and functions. Curr Opin Struct Biol. 1998;8:785–91.
Fischer RS, Fowler VM. Thematic minireview series: the state of the cytoskeleton in 2015. J Biol Chem. 2015;290:17133–6. https://doi.org/10.1074/jbc.R115.663716.
Fletcher DA, Mullins RD. Cell mechanics and the cytoskeleton. Nature. 2010;463:485–92. https://doi.org/10.1038/nature08908.
Garcia-Mayoral MF, Castano R, Fanarraga ML, Zabala JC, Rico M, Bruix M. The solution structure of the N-terminal domain of human tubulin binding cofactor C reveals a platform for tubulin interaction. PloS one. 2011;6:e25912. https://doi.org/10.1371/journal.pone.0025912.
Gonçalves J, Nolasco S, Nascimento R, Lopez Fanarraga M, Zabala JC, Soares H. TBCCD1, a new centrosomal protein, is required for centrosome and Golgi apparatus positioning. EMBO Rep. 2010a;11:194–200. https://doi.org/10.1038/embor.2010.5.
Gonçalves J, Tavares A, Carvalhal S, Soares H. Revisiting the tubulin folding pathway: new roles in centrosomes and cilia. Biomol Concepts. 2010b;1:423–34. https://doi.org/10.1515/bmc.2010.033.
Grayson C, Bartolini F, Chapple JP, Willison KR, Bhamidipati A, Lewis SA, et al. Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3. Hum Mol Genet. 2002;11:3065–74.
Hage-Sleiman R, Herveau S, Matera EL, Laurier JF, Dumontet C. Tubulin binding cofactor C (TBCC) suppresses tumor growth and enhances chemosensitivity in human breast cancer cells. BMC Cancer. 2010;10:135. https://doi.org/10.1186/1471-2407-10-135.
Hage-Sleiman R, Herveau S, Matera EL, Laurier JF, Dumontet C. Silencing of tubulin binding cofactor C modifies microtubule dynamics and cell cycle distribution and enhances sensitivity to gemcitabine in breast cancer cells. Mol Cancer Ther. 2011;10:303–12. https://doi.org/10.1158/1535-7163.MCT-10-0568.
Kirik V, Mathur J, Grini PE, Klinkhammer I, Adler K, Bechtold N, et al. Functional analysis of the tubulin-folding cofactor C in Arabidopsis thaliana. Curr Biol. 2002;12:1519–23.
Kollman JM, Merdes A, Mourey L, Agard DA. Microtubule nucleation by gamma-tubulin complexes. Nat Rev Mol Cell Biol. 2011;12:709–21. https://doi.org/10.1038/nrm3209.
Luders J. The amorphous pericentriolar cloud takes shape. Nat Cell Biol. 2012;14:1126–8. https://doi.org/10.1038/ncb2617.
Mori R, Toda T. The dual role of fission yeast Tbc1/cofactor C orchestrates microtubule homeostasis in tubulin folding and acts as a GAP for GTPase Alp41/Arl2. Mol Biol Cell. 2013;24:1713–24. S1-8. https://doi.org/10.1091/mbc.E12-11-0792.
Nogales E. Structural insight into microtubule function. Annu Rev Biophys Biomol Struct. 2001;30:397–420. https://doi.org/10.1146/annurev.biophys.30.1.397.
Schwahn U, Lenzner S, Dong J, Feil S, Hinzmann B, van Duijnhoven G, et al. Positional cloning of the gene for X-linked retinitis pigmentosa 2. Nat Genet. 1998;19:327–32. https://doi.org/10.1038/1214.
Serna M, Zabala JC. Tubulin folding and degradation. Chichester: eLS Wiley; 2016. https://doi.org/10.1002/9780470015902.a0026333.
Steinborn K, Maulbetsch C, Priester B, Trautmann S, Pacher T, Geiges B, et al. The Arabidopsis PILZ group genes encode tubulin-folding cofactor orthologs required for cell division but not cell growth. Genes Dev. 2002;16:959–71. https://doi.org/10.1101/gad.221702.
Tian G, Huang Y, Rommelaere H, Vandekerckhove J, Ampe C, Cowan NJ. Pathway leading to correctly folded beta-tubulin. Cell. 1996;86:287–96.
Tian G, Bhamidipati A, Cowan NJ, Lewis SA. Tubulin folding cofactors as GTPase-activating proteins. GTP hydrolysis and the assembly of the alpha/beta-tubulin heterodimer. J Biol Chem. 1999;274:24054–8.
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Camelo, C., Peneda, C., Carmona, B., Soares, H. (2018). TBCC. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101508
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