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Effect of Intrinsic and Extrinsic Lipids on T-Cell Signaling

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Abstract

T-cell activation is dependent on activating and inhibitory signals, and cell fate is influenced by the interplay between these different signaling pathways. Because proximal events are relayed through the membrane via specific membrane microdomains called rafts, the lipid composition of the plasma membrane critically influences signal transduction and thus cellular functions. Rafts are highly motile domains, enriched in cholesterol compared to the rest of the membrane. Their specific lipid composition makes these domains very sensitive to external changes such as variations in the cholesterol and saturated and unsaturated fatty acid content of the immediate environment. Immune cells, and in particular T cells, depend on membrane raft integrity for initiating signaling, so dysregulation of the processes involved in the maintenance of an adequate lipid environment is likely to be a significant modulator of immune functions. In this chapter, we will review the modulation of TcR-dependent signaling events by lipids in in vitro and in vivo models focusing on the involvement of membrane rafts. Clinical cases such as autoimmune diseases, aging, and Alzheimer’s disease will be used to illustrate recent findings in this field.

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Acknowledgments

This work was supported by grants from Canadian Institutes of Health Research (CIHR) (No. 106634), the Société des médecins de l’Université de Sherbrooke, and the Research Center on Aging of the CIUSSS-CHUS, Sherbrooke.

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Authors and Affiliations

  1. Singapore Immunology Network (SIgN), Agency for Science Technology and Research (A-Star), Singapore, Singapore

    Anis Larbi

  2. Section of medicine and therapeutics, Western Infirmary, University of Glasgow, Glasgow, UK

    Emilie Combet Aspray

  3. Department of Internal Medicine II, Center for Medical Research University of Tübingen, Tübingen, Germany

    Graham Pawelec

  4. Health Sciences North Research Institute, Sudbury, ON, Canada

    Graham Pawelec

  5. Research Center on Aging, Graduate Program in Immunology, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC, Canada

    Abdelouahed Khalil & Tamas Fulop

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  3. Graham Pawelec
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  4. Abdelouahed Khalil
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  5. Tamas Fulop
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Correspondence to Anis Larbi .

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Editors and Affiliations

  1. Division of Geriatrics Research Center on Aging, University of Sherbrooke Dept. of Medicine, Sherbrooke, QC, Canada

    Tamas Fulop

  2. Dept of Experimental Pathology, University of Bologna, Bologna, Italy

    Claudio Franceschi

  3. Institute for Health and Life Sciences, Tokyo, Japan

    Katsuiku Hirokawa

  4. Center for Medical Research, University of Tübingen, Tübingen, Germany

    Graham Pawelec

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Larbi, A., Combet Aspray, E., Pawelec, G., Khalil, A., Fulop, T. (2018). Effect of Intrinsic and Extrinsic Lipids on T-Cell Signaling. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook of Immunosenescence. Springer, Cham. https://doi.org/10.1007/978-3-319-64597-1_69-1

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  • DOI: https://doi.org/10.1007/978-3-319-64597-1_69-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-64597-1

  • Online ISBN: 978-3-319-64597-1

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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