Abstract
Immunosenescence is the multifactorial age-associated immune deterioration that leads to increased susceptibility to infections and decreased responses to vaccines. The mechanisms of immunosenescence remain incompletely understood but include the well-described hallmarks of aging, such as accumulation of damaged cellular proteins and inefficient autophagy, mitochondrial dysfunction leading to accumulation of reactive oxygen species and oxidative damage, and genomic instability – telomere shortening and DNA damage. Recent studies have shown that noncoding RNAs are important regulators of cellular mechanisms underlying numerous biological processes, and they play a fundamental role in regulating mechanisms of cellular aging. Here, we will review a role for ncRNAs in cellular aging pathways relevant to immune responses and dysregulation, cellular stress responses, and areas of active investigation that may increase our understanding of immunosenescence.
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Acknowledgments
This work was supported in part by the National Natural Science Foundation of China (No. 81370464) and the National Institutes of Health (HHS N272201100019C, U19AI089992). The authors regret omission of many important articles due to space limitations and thank many colleagues for insightful discussions. We thank Ms. Anna Malawista for valuable assistance.
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Wang, W., Qian, F., Montgomery, R.R. (2018). Age-Related Changes in Immune Regulation by Noncoding RNAs. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook of Immunosenescence. Springer, Cham. https://doi.org/10.1007/978-3-319-64597-1_109-1
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