Abstract
The radionuclide diagnostics unit, described in the article, detects pathological changes of organs and systems of a person. The device is a portable detector of gamma rays that allows to diagnose superficial malignancies using radiopharmaceuticals injected into the body. The gamma probe uses crystal LaBr3:Ce as a scintillator and silicon photomultiplier SiPM as a photodetector. The focus of this paper is the improvement of the amplifier, which originally produced misshapen pulses unsuitable for energy discrimination. Using LTSPICE, a free circuit-modelling program, we performed extensive simulation of both the SiPM and the amplifier. From this work, we determined that high input impedance and unnecessarily high gain were the source of the distortion. Another amplifier better suited to the SiPM parameters was simulated and then prototyped.
The original version of this chapter was revised: For detailed information please see correction chapter. The correction to this chapter is available at https://doi.org/10.1007/978-3-319-63940-6_51
Change history
12 October 2018
A correction has been published.
References
Cancer. Fact sheet N°297. World Health Organization (2015). http://www.who.int/mediacentre/factsheets/fs297/en. Accessed Feb 2015
Blokhin, N.N., Peterson, B.B.: Clinical oncology, M. (1979)
Stewart, B., Wild, C.P. (eds.): World Cancer Report 2014. IARC Nonserial Publication, 630 p. (2014)
De Martel, C., Ferlay, J., Franceschi, S., et al.: Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncology 13, 607–615 (2012)
Zubovsky, G.A.: Gammascintigraph, M. (1978)
Zedgenidze, G.A. (ed.): Clinical Radiology, vol. 4, Moscow (1985)
Gamma Probes. IntraMedical Imaging (2014). http://www.gammaprobe.com/products/gamma-probes
Wengenmair, H., Kopp, J.: Gamma probes for sentinel lymph node localization: quality criteria, minimal requirements and quality of commercially available systems (2005). http://www.klinikum-augsburg.de/index.php/fuseaction/download/lrn_file/gammaprobes.pdf
Da Costa, F.E., Rela, P.R., de Oliveira, I.B., Pereira, M.C.C., Hamada, M.M.: Surgical gamma probe with TlBr semiconductor for identification of sentinel lymph node. In: IEEE Nuclear Science Symposium Conference Record, pp. 2890–2894 (2005)
Wei, L., Chen, F., Zhang, X., Li, D., Yao, Z., Deng, L., Xiao, G.: 99mTc-dextran lymphoscintigraphy can detect sentinel lymph node in breast cancer patients. Exp. Therap. Med. 9(1), 112–116 (2015)
Bogliolo, S., Marchiole, P., Sala, P., Giardina, E., Villa, G., Fulcheri, E., Menada, M.V.: Sentinel node mapping with radiotracer alone in vulvar cancer: a five year single-centre experience and literature review. Eur. J. Gynaecol. Oncol. 36(1), 10–15 (2015)
Endo, K., Ueno, T., Tsuji, A., Kondo, S., Wakisaka, N., Murono, S., Yoshizaki, T.: Sentinel node biopsy and tumor-targeted chemotherapy for oral squamous cell carcinoma. Oto-Rhino-Laryngol. Tokyo 56(5), 329–331 (2014)
Matheoud, R., Giorgione, R., Valzano, S., Sacchetti, G., Colombo, E., Brambilla, M.: Minimum acceptable sensitivity of intraoperative gamma probes used for sentinel lymph node detection in melanoma patients. Physica Med. 30(7), 822–826 (2014)
Grigorenko, A., Panfilov, L., Smirnov, A., Starikovskiy, A., Rubin, D., Shulga, E., Sychev, N., Nikolaeva, A.: The existing gamma-probes review for searching functional increase and complex improvement possibilities. Biosci. Biotechnol. Res. Asia 12, 197–200 (2015)
Lebedev, G.N., Yagnyukova, A.K., Tolstaya, A.M., Bulychev, I.G.: Gamma-probe based on scintillation crystal and silicon photomultipliers for cancer detection. Int. J. Tomogr. Simul. 29(3), 92–103 (2016)
Romanova, S.: Nuclear medicine: status and prospects. Remedium (6), 8–20 (2013)
Georgiou, M.: Evaluation of an imaging gamma probe based on R8900U-00-C12 PSPMT. In: IEEE Nuclear Science Symposium and Medical Imaging Conference, pp. 4020–4023 (2011)
Seifert, S., van Dam, H.T., Huizenga, J., Vinke, R., Dendooven, P., Lohner, H., Schaart, D.R.: Simulation of silicon photomultiplier signals. IEEE Trans. Nucl. Sci. 56(6), 3726–3733 (2009)
Wangerin, K.A., Wang, G.-C., Kim, C., Danon, Y.: Passive electrical model of silicon photomultipliers. In: IEEE Nuclear Science Symposium Conference Record, pp. 4906–4913 (2008)
Yagnyukova, A., Mikhaylov, D., Khabibullin, T., Grigorenko, A., Leonid, P.: Gamma-probe for revealing cancerous cells. Stud. Ethno-Med. (2015)
Christillin, P.: Nuclear Compton scattering. J. Phys. G: Nucl. Phys. 12(9), 837–851 (1986)
Compton scattering. http://en.academic.ru/dic.nsf/enwiki/35148
Acknowledgments
This work was supported by Competitiveness Growth Program of the Federal Autonomous Educational Institution of Higher Professional Education National Research Nuclear University MEPhI (Moscow Engineering Physics Institute).
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Khabibullin, T., Starikovskiy, A., Tolstaya, A. (2018). Gamma-Probe for Locating the Source of Ionizing Radiation. In: Samsonovich, A., Klimov, V. (eds) Biologically Inspired Cognitive Architectures (BICA) for Young Scientists. BICA 2017. Advances in Intelligent Systems and Computing, vol 636. Springer, Cham. https://doi.org/10.1007/978-3-319-63940-6_37
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DOI: https://doi.org/10.1007/978-3-319-63940-6_37
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