Skip to main content

Primary and Secondary Environmental Control Measures for Allergic Diseases

  • Living reference work entry
  • First Online:
Allergy and Asthma

Abstract

Atopic diseases, such as allergic rhinitis, asthma, atopic dermatitis, and food allergy, prevalence continues increasing worldwide. They are characterized by the production of IgE to diverse allergens. Atopic diseases represent an important health and economic burden in our population. The development of atopic diseases is a consequence of the interactions of multiple factors, including genetic predisposition, environment, infections, microflora, diet, and use of different medications. Great effort has been placed in the development of diverse strategies to prevent these atopic diseases. Primary prevention is focused in the development of measures to avoid sensitization. The goal of secondary prevention is to avoid the development of symptoms once sensitization is present. However, due to pathogenesis complexity of these diseases diverse results have been reported. In this chapter, the effectiveness of different primary and secondary interventions and control measures of common allergens will be discussed in detail.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  • Adamson AS. The economics burden of atopic dermatitis. In: Erica Fortson SRF, Strowd LC, editors. Management of atopic dermatitis. Cham: Springer; 2017. p. 79–92.

    Chapter  Google Scholar 

  • Akinbami LJ, Simon AE, Schoendorf KC. Trends in allergy prevalence among children aged 0-17 years by asthma status, United States, 2001–2013. J Asthma. 2016;53:356–62.

    Article  PubMed  PubMed Central  Google Scholar 

  • Allen KJ, Koplin JJ, Ponsonby AL, Gurrin LC, Wake M, Vuillermin P, Martin P, Matheson M, Lowe A, Robinson M, Tey D, Osborne NJ, Dang T, Tina Tan HT, Thiele L, Anderson D, Czech H, Sanjeevan J, Zurzolo G, Dwyer T, Tang ML, Hill D, Dharmage SC. Vitamin D insufficiency is associated with challenge-proven food allergy in infants. J Allergy Clin Immunol. 2013;131:1109–16, 1116 E1-6

    Article  CAS  PubMed  Google Scholar 

  • Anderson HR, Poloniecki JD, Strachan DP, Beasley R, Bjorksten B, Asher MI, Group, I. P. S. Immunization and symptoms of atopic disease in children: results from the international study of asthma and allergies in childhood. Am J Public Health. 2001;91:1126–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • APPA. The 2017–2018 APPA national pet owners survey debut [online]. Greenwich. 2018. Available: www.americanpetproducts.org. Accessed 25 Feb 2018.

  • Appel AG. Performance of gel and paste bait products for german cockroach (Dictyoptera: Blattellidae) control: laboratory and field studies. J Econ Entomol. 1992;85:1176–83.

    Article  CAS  PubMed  Google Scholar 

  • Arbes SJ Jr, Cohn RD, Yin M, Muilenberg ML, Friedman W, Zeldin DC. Dog allergen (Can F 1) and cat allergen (Fel D 1) in US homes: Results from the National Survey of Lead and Allergens in Housing. J Allergy Clin Immunol. 2004;114:111–7.

    Article  PubMed  Google Scholar 

  • Arlian LG, Neal JS, Morgan MS, Rapp CM, Clobes AL. Distribution and removal of cat, dog and mite allergens on smooth surfaces in homes with and without pets. Ann Allergy Asthma Immunol. 2001a;87:296–302.

    Article  CAS  PubMed  Google Scholar 

  • Arlian LG, Neal JS, Morgan MS, Vyszenski-Moher DL, Rapp CM, Alexander AK. Reducing relative humidity is a practical way to control dust mites and their allergens in homes in temperate climates. J Allergy Clin Immunol. 2001b;107:99–104.

    Article  CAS  PubMed  Google Scholar 

  • Arlian LG, Vyszenski-Moher DL, Morgan MS. Mite and mite allergen removal during machine washing of laundry. J Allergy Clin Immunol. 2003;111:1269–73.

    Article  PubMed  Google Scholar 

  • Arroyave WD, Rabito FA, Carlson JC, Friedman EE, Stinebaugh SJ. Impermeable dust mite covers in the primary and tertiary prevention of allergic disease: a meta-analysis. Ann Allergy Asthma Immunol. 2014;112:237–48.

    Article  PubMed  Google Scholar 

  • Arruda LK, Chapman MD. The role of cockroach allergens in asthma. Curr Opin Pulm Med. 2001;7:14–9.

    Article  CAS  PubMed  Google Scholar 

  • Arruda LK, Vailes LD, Ferriani VP, Santos AB, Pomes A, Chapman MD. Cockroach allergens and asthma. J Allergy Clin Immunol. 2001;107:419–28.

    Article  CAS  PubMed  Google Scholar 

  • Avershina E, Ravi A, Storro O, Oien T, Johnsen R, Rudi K. Potential association of vacuum cleaning frequency with an altered gut microbiota in pregnant women and their 2-year-old children. Microbiome. 2015;3:65.

    Article  PubMed  PubMed Central  Google Scholar 

  • Avershina E, Cabrera Rubio R, Lundgard K, Perez Martinez G, Collado MC, Storro O, Oien T, Dotterud CK, Johnsen R, Rudi K. Effect of probiotics in prevention of atopic dermatitis is dependent on the intrinsic microbiota at early infancy. J Allergy Clin Immunol. 2017;139:1399–402. E8

    Article  PubMed  Google Scholar 

  • Avner DB, Perzanowski MS, Platts-Mills TA, Woodfolk JA. Evaluation of different techniques for washing cats: quantitation of allergen removed from the cat and the effect on airborne Fel D 1. J Allergy Clin Immunol. 1997;100:307–12.

    Article  CAS  PubMed  Google Scholar 

  • Banerjee S, Resch Y, Chen KW, Swoboda I, Focke-Tejkl M, Blatt K, Novak N, Wickman M, Van Hage M, Ferrara R, Mari A, Purohit A, Pauli G, Sibanda EN, Ndlovu P, Thomas WR, Krzyzanek V, Tacke S, Malkus U, Valent P, Valenta R, Vrtala S. Der P 11 is a major allergen for house dust mite-allergic patients suffering from atopic dermatitis. J Invest Dermatol. 2015;135:102–9.

    Article  CAS  PubMed  Google Scholar 

  • Barnes CS, Dowling P, Van Osdol T, Portnoy J. Comparison of indoor fungal spore levels before and after professional home remediation. Ann Allergy Asthma Immunol. 2007;98:262–8.

    Article  PubMed  Google Scholar 

  • Barnes CS, Horner WE, Kennedy K, Grimes C, Miller JD, Environmental Allergens W. Home assessment and remediation. J Allergy Clin Immunol Pract. 2016;4:423–31. E15

    Article  PubMed  Google Scholar 

  • Barry HC. Mite-impermeable covers decrease hospital visits in kids with asthma. Am Fam Physician. 2017;96, Online.

    Google Scholar 

  • Bellach J, Schwarz V, Ahrens B, Trendelenburg V, Aksunger O, Kalb B, Niggemann B, Keil T, Beyer K. Randomized placebo-controlled trial of hen’s egg consumption for primary prevention in infants. J Allergy Clin Immunol. 2017;139:1591–9. E2

    Article  CAS  PubMed  Google Scholar 

  • Bergmann RL, Diepgen TL, Kuss O, Bergmann KE, Kujat J, Dudenhausen JW, Wahn U, Group, M. A.-S. Breastfeeding duration is a risk factor for atopic eczema. Clin Exp Allergy. 2002;32:205–9.

    Article  PubMed  Google Scholar 

  • Bisgaard H, Stokholm J, Chawes BL, Vissing NH, Bjarnadottir E, Schoos AM, Wolsk HM, Pedersen TM, Vinding RK, Thorsteinsdottir S, Folsgaard NV, Fink NR, Thorsen J, Pedersen AG, Waage J, Rasmussen MA, Stark KD, Olsen SF, Bonnelykke K. Fish oil-derived fatty acids in pregnancy and wheeze and asthma in offspring. N Engl J Med. 2016;375:2530–9.

    Article  CAS  PubMed  Google Scholar 

  • Bousquet PJ, Chinn S, Janson C, Kogevinas M, Burney P, Jarvis D, European Community Respiratory Health Survey, I. Geographical variation in the prevalence of positive skin tests to environmental aeroallergens in the European Community Respiratory Health Survey I. Allergy. 2007;62:301–9.

    Article  PubMed  Google Scholar 

  • Boyce JA, Assa’ad A, Burks AW, Jones SM, Sampson HA, Wood RA, Plaut M, Cooper SF, Fenton MJ, Arshad SH, Bahna SL, Beck LA, Byrd-Bredbenner C, Camargo CA Jr, Eichenfield L, Furuta GT, Hanifin JM, Jones C, Kraft M, Levy BD, Lieberman P, Luccioli S, Mccall KM, Schneider LC, Simon RA, Simons FE, Teach SJ, Yawn BP, Schwaninger JM, Panel NI-SE. Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-sponsored expert panel report. J Allergy Clin Immunol. 2010;126:1105–18.

    Article  PubMed  PubMed Central  Google Scholar 

  • Bremmer SF, Simpson EL. Dust mite avoidance for the primary prevention of atopic dermatitis: a systematic review and meta-analysis. Pediatr Allergy Immunol. 2015;26:646–54.

    Article  PubMed  Google Scholar 

  • Breuer K, Heratizadeh A, Wulf A, Baumann U, Constien A, Tetau D, Kapp A, Werfel T. Late eczematous reactions to food in children with atopic dermatitis. Clin Exp Allergy. 2004;34:817–24.

    Article  CAS  PubMed  Google Scholar 

  • Bridgman SL, Kozyrskyj AL, Scott JA, Becker AB, Azad MB. Gut microbiota and allergic disease in children. Ann Allergy Asthma Immunol. 2016;116:99–105.

    Article  PubMed  Google Scholar 

  • Broughton S, Sylvester KP, Fox G, Zuckerman M, Smith M, Milner AD, Rafferty GF, Greenough A. Lung function in prematurely born infants after viral lower respiratory tract infections. Pediatr Infect Dis J. 2007;26:1019–24.

    Article  PubMed  Google Scholar 

  • Brown KW, Minegishi T, Allen JG, Mccarthy JF, Spengler JD, Macintosh DL. Reducing patients’ exposures to asthma and allergy triggers in their homes: an evaluation of effectiveness of grades of forced air ventilation filters. J Asthma. 2014;51:585–94.

    Article  PubMed  PubMed Central  Google Scholar 

  • Bustos GJ, Bustos D, Bustos GJ, Romero O. Prevention of asthma with ketotifen in preasthmatic children: a three-year follow-up study. Clin Exp Allergy. 1995;25:568–73.

    Article  CAS  PubMed  Google Scholar 

  • Butt A, Rashid D, Lockey RF. Do hypoallergenic cats and dogs exist? Ann Allergy Asthma Immunol. 2012;108:74–6.

    Article  PubMed  Google Scholar 

  • Byeon JH, Ri S, Amarsaikhan O, Kim E, Ahn SH, Choi IS, Kim HJ, Seo S, Yoon W, Yoo Y. Association between sensitization to mold and impaired pulmonary function in children with asthma. Allergy Asthma Immunol Res. 2017;9:509–16.

    Article  PubMed  PubMed Central  Google Scholar 

  • Carlson JC, Rabito FA, Werthmann D, Fox M. The distribution and movement of American cockroaches in urban niches of New Orleans. Clin Pediatr (Phila). 2017;56:1008–12.

    Article  Google Scholar 

  • CDC. Most recent asthma data [online]. Available: https://www.cdc.gov/asthma/most_recent_data.htm. Accessed 24 Feb 2018.

  • Chang TS, Lemanske RF Jr, Guilbert TW, Gern JE, Coen MH, Evans MD, Gangnon RE, David Page C, Jackson DJ. Evaluation of the modified asthma predictive index in high-risk preschool children. J Allergy Clin Immunol Pract. 2013;1:152–6.

    Article  PubMed  Google Scholar 

  • Chan-Yeung M, Manfreda J, Dimich-Ward H, Ferguson A, Watson W, Becker A. A randomized controlled study on the effectiveness of a multifaceted intervention program in the primary prevention of asthma in high-risk infants. Arch Pediatr Adolesc Med. 2000;154:657–63.

    Article  CAS  PubMed  Google Scholar 

  • Chapman MD, Pomes A, Breiteneder H, Ferreira F. Nomenclature and structural biology of allergens. J Allergy Clin Immunol. 2007;119:414–20.

    Article  CAS  PubMed  Google Scholar 

  • Chatzi L, Apostolaki G, Bibakis I, Skypala I, Bibaki-Liakou V, Tzanakis N, Kogevinas M, Cullinan P. Protective effect of fruits, vegetables and the mediterranean diet on asthma and allergies among children in Crete. Thorax. 2007;62:677–83.

    Article  PubMed  PubMed Central  Google Scholar 

  • Chawes BL, Bonnelykke K, Stokholm J, Vissing NH, Bjarnadottir E, Schoos AM, Wolsk HM, Pedersen TM, Vinding RK, Thorsteinsdottir S, Arianto L, Hallas HW, Heickendorff L, Brix S, Rasmussen MA, Bisgaard H. Effect of vitamin D3 supplementation during pregnancy on risk of persistent wheeze in the offspring: a randomized clinical trial. JAMA. 2016;315:353–61.

    Article  CAS  PubMed  Google Scholar 

  • Cheng HM, Kim S, Park GH, Chang SE, Bang S, Won CH, Lee MW, Choi JH, Moon KC. Low vitamin D levels are associated with atopic dermatitis, but not allergic rhinitis, asthma, or ige sensitization, in the adult korean population. J Allergy Clin Immunol. 2014;133:1048–55.

    Article  CAS  PubMed  Google Scholar 

  • Choi SY, Lee IY, Sohn JH, Lee YW, Shin YS, Yong TS, Hong CS, Park JW. Optimal conditions for the removal of house dust mite, dog dander, and pollen allergens using mechanical laundry. Ann Allergy Asthma Immunol. 2008;100:583–8.

    Article  PubMed  Google Scholar 

  • Christensen S, Jaffar Z, Cole E, Porter V, Ferrini M, Postma B, Pinkerton KE, Yang M, Kim YJ, Montrose L, Roberts K, Holian A, Cho YH. Prenatal environmental tobacco smoke exposure increases allergic asthma risk with methylation changes in mice. Environ Mol Mutagen. 2017;58:423–33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Codispoti CD, Levin L, Lemasters GK, Ryan P, Reponen T, Villareal M, Burkle J, Stanforth S, Lockey JE, Khurana Hershey GK, Bernstein DI. Breast-feeding, aeroallergen sensitization, and environmental exposures during infancy are determinants of childhood allergic rhinitis. J Allergy Clin Immunol. 2010;125:1054–60. E1

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Colloff MJ, Taylor C, Merrett TG. The use of domestic steam cleaning for the control of house dust mites. Clin Exp Allergy. 1995;25:1061–6.

    Article  CAS  PubMed  Google Scholar 

  • Cuello-Garcia CA, Brozek JL, Fiocchi A, Pawankar R, Yepes-Nunez JJ, Terracciano L, Gandhi S, Agarwal A, Zhang Y, Schunemann HJ. Probiotics for the prevention of allergy: a systematic review and meta-analysis of randomized controlled trials. J Allergy Clin Immunol. 2015;136:952–61.

    Article  PubMed  Google Scholar 

  • Cuello-Garcia C, Fiocchi A, Pawankar R, Yepes-Nunez JJ, Morgano GP, Zhang Y, Agarwal A, Gandhi S, Terracciano L, Schunemann HJ, Brozek JL. Prebiotics for the prevention of allergies: a systematic review and meta-analysis of randomized controlled trials. Clin Exp Allergy. 2017;47:1468–77.

    Article  CAS  PubMed  Google Scholar 

  • Custovic A, Taggart SC, Kennaugh JH, Woodcock A. Portable dehumidifiers in the control of house dust mites and mite allergens. Clin Exp Allergy. 1995;25:312–6.

    Article  CAS  PubMed  Google Scholar 

  • Custovic A, Green R, Fletcher A, Smith A, Pickering CA, Chapman MD, Woodcock A. Aerodynamic properties of the major dog allergen Can F 1: distribution in homes, concentration, and particle size of allergen in the air. Am J Respir Crit Care Med. 1997;155:94–8.

    Article  CAS  PubMed  Google Scholar 

  • Custovic A, Hallam CL, Simpson BM, Craven M, Simpson A, Woodcock A. Decreased prevalence of sensitization to cats with high exposure to cat allergen. J Allergy Clin Immunol. 2001;108:537–9.

    Article  CAS  PubMed  Google Scholar 

  • Czarnowicki T, Malajian D, Khattri S, Correa Da Rosa J, Dutt R, Finney R, Dhingra N, Xiangyu P, Xu H, Estrada YD, Zheng X, Gilleaudeau P, Sullivan-Whalen M, Suarez-Farinas M, Shemer A, Krueger JG, Guttman-Yassky E. Petrolatum: barrier repair and antimicrobial responses underlying this “inert” moisturizer. J Allergy Clin Immunol. 2016;137:1091–102. E7

    Article  CAS  PubMed  Google Scholar 

  • De Batlle J, Garcia-Aymerich J, Barraza-Villarreal A, Anto JM, Romieu I. Mediterranean diet is associated with reduced asthma and rhinitis in Mexican children. Allergy. 2008;63:1310–6.

    Article  PubMed  Google Scholar 

  • De Blay F, Chapman MD, Platts-Mills TA. Airborne cat allergen (Fel D I). Environmental control with the cat in situ. Am Rev Respir Dis. 1991;143:1334–9.

    Article  PubMed  Google Scholar 

  • De Lucca SD, Taylor DJ, O’meara TJ, Jones AS, Tovey ER. Measurement and characterization of cockroach allergens detected during normal domestic activity. J Allergy Clin Immunol. 1999;104:672–80.

    Article  PubMed  Google Scholar 

  • De Silva D, Geromi M, Halken S, Host A, Panesar SS, Muraro A, Werfel T, Hoffmann-Sommergruber K, Roberts G, Cardona V, Dubois AE, Poulsen LK, Van Ree R, Vlieg-Boerstra B, Agache I, Grimshaw K, O’mahony L, Venter C, Arshad SH, Sheikh A, Allergy EF, Anaphylaxis Guidelines, G. Primary prevention of food allergy in children and adults: systematic review. Allergy. 2014;69:581–9.

    Article  PubMed  Google Scholar 

  • De Weger LA, Hiemstra PS. The effect of climate change on pollen allergy in the Netherlands. Ned Tijdschr Geneeskd. 2009;153:A1410.

    PubMed  Google Scholar 

  • Des Roches A, Paradis L, Menardo JL, Bouges S, Daures JP, Bousquet J. Immunotherapy with a standardized Dermatophagoides pteronyssinus extract. VI. Specific immunotherapy prevents the onset of new sensitizations in children. J Allergy Clin Immunol. 1997;99:450–3.

    Article  CAS  PubMed  Google Scholar 

  • Dimango E, Serebrisky D, Narula S, Shim C, Keating C, Sheares B, Perzanowski M, Miller R, Dimango A, Andrews H, Merle D, Liu X, Calatroni A, Kattan M. Individualized household allergen intervention lowers allergen level but not asthma medication use: a randomized controlled trial. J Allergy Clin Immunol Pract. 2016;4:671–9. E4

    Article  PubMed  PubMed Central  Google Scholar 

  • Du Toit G, Roberts G, Sayre PH, Bahnson HT, Radulovic S, Santos AF, Brough HA, Phippard D, Basting M, Feeney M, Turcanu V, Sever ML, Gomez Lorenzo M, Plaut M, Lack G, Team LS. Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med. 2015;372:803–13.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Du Toit G, Tsakok T, Lack S, Lack G. Prevention of food allergy. J Allergy Clin Immunol. 2016;137:998–1010.

    Article  PubMed  CAS  Google Scholar 

  • Dumez ME, Herman J, Campizi V, Galleni M, Jacquet A, Chevigne A. Orchestration of an uncommon maturation cascade of the house dust mite protease allergen quartet. Front Immunol. 2014;5:138.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Eggleston PA, Rosenstreich D, Lynn H, Gergen P, Baker D, Kattan M, Mortimer KM, Mitchell H, Ownby D, Slavin R, Malveaux F. Relationship of indoor allergen exposure to skin test sensitivity in inner-city children with asthma. J Allergy Clin Immunol. 1998;102:563–70.

    Article  CAS  PubMed  Google Scholar 

  • Ek WE, Karlsson T, Hernandes CA, Rask-Andersen M, Johansson A. Breast-feeding and risk of asthma, hay fever, and eczema. J Allergy Clin Immunol. 2018;141(3):1157–59.

    Article  PubMed  Google Scholar 

  • El-Ghitany EM, Abd El-Salam MM. Environmental intervention for house dust mite control in childhood bronchial asthma. Environ Health Prev Med. 2012;17:377–84.

    Article  PubMed  PubMed Central  Google Scholar 

  • Enberg RN, Shamie SM, Mccullough J, Ownby DR. Ubiquitous presence of cat allergen in cat-free buildings: probable dispersal from human clothing. Ann Allergy. 1993;70:471–4.

    CAS  PubMed  Google Scholar 

  • Eng PA, Reinhold M, Gnehm HP. Long-term efficacy of preseasonal grass pollen immunotherapy in children. Allergy. 2002;57:306–12.

    Article  CAS  PubMed  Google Scholar 

  • Farooqi IS, Hopkin JM. Early childhood infection and atopic disorder. Thorax. 1998;53:927–32.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Feichtner CR, Arlian LG, Morgan MS, Vyszenski-Moher DL. Home freezers kill house dust mites. J Allergy Clin Immunol. 2018;141:451–4.

    Article  PubMed  Google Scholar 

  • Feng M, Yang Z, Pan L, Lai X, Xian M, Huang X, Chen Y, Schroder PC, Roponen M, Schaub B, Wong GW, Li J. Associations of early life exposures and environmental factors with asthma among children in rural and urban areas of Guangdong, China. Chest. 2016;149:1030–41.

    Article  PubMed  Google Scholar 

  • Filep S, Tsay A, Vailes L, Gadermaier G, Ferreira F, Matsui E, King EM, Chapman MD. A multi-allergen standard for the calibration of immunoassays: create principles applied to eight purified allergens. Allergy. 2012;67:235–41.

    Article  CAS  PubMed  Google Scholar 

  • Fogarty A, Lewis S, Weiss S, Britton J. Dietary vitamin E, IgE concentrations, and atopy. Lancet. 2000;356:1573–4.

    Article  CAS  PubMed  Google Scholar 

  • Foolad N, Brezinski EA, Chase EP, Armstrong AW. Effect of nutrient supplementation on atopic dermatitis in children: a systematic review of probiotics, prebiotics, formula, and fatty acids. JAMA Dermatol. 2013;149:350–5.

    Article  CAS  PubMed  Google Scholar 

  • Francis H, Fletcher G, Anthony C, Pickering C, Oldham L, Hadley E, Custovic A, Niven R. Clinical effects of air filters in homes of asthmatic adults sensitized and exposed to pet allergens. Clin Exp Allergy. 2003;33:101–5.

    Article  CAS  PubMed  Google Scholar 

  • Fujimura T, Aki T, Isobe T, Matsuoka A, Hayashi T, Ono K, Kawamoto S. Der F 35: an Md-2-like house dust mite allergen that cross-reacts with Der F 2 and Pso O 2. Allergy. 2017;72:1728–36.

    Article  CAS  PubMed  Google Scholar 

  • Gabriel MF, Postigo I, Tomaz CT, Martinez J. Alternaria alternata allergens: markers of exposure, phylogeny and risk of fungi-induced respiratory allergy. Environ Int. 2016;89–90:71–80.

    Article  PubMed  Google Scholar 

  • Gale CR, Robinson SM, Harvey NC, Javaid MK, Jiang B, Martyn CN, Godfrey KM, Cooper C, Princess Anne Hospital Study, G. Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr. 2008;62:68–77.

    Article  CAS  PubMed  Google Scholar 

  • Gdalevich M, Mimouni D, David M, Mimouni M. Breast-feeding and the onset of atopic dermatitis in childhood: a systematic review and meta-analysis of prospective studies. J Am Acad Dermatol. 2001;45:520–7.

    Article  CAS  PubMed  Google Scholar 

  • Gehring U, De Jongste JC, Kerkhof M, Oldewening M, Postma D, Van Strien RT, Wijga AH, Willers SM, Wolse A, Gerritsen J, Smit HA, Brunekreef B. The 8-year follow-up of the PIAMA intervention study assessing the effect of mite-impermeable mattress covers. Allergy. 2012;67:248–56.

    Article  CAS  PubMed  Google Scholar 

  • Gergen PJ, Mitchell HE, Calatroni A, Sever ML, Cohn RD, Salo PM, Thorne PS, Zeldin DC. Sensitization and exposure to pets: the effect on asthma morbidity In the US population. J Allergy Clin Immunol Pract. 2018;6:101–7. E2

    Article  PubMed  Google Scholar 

  • Gilliland FD, Li YF, Peters JM. Effects of maternal smoking during pregnancy and environmental tobacco smoke on asthma and wheezing in children. Am J Respir Crit Care Med. 2001;163:429–36.

    Article  CAS  PubMed  Google Scholar 

  • Goldring ST, Griffiths CJ, Martineau AR, Robinson S, Yu C, Poulton S, Kirkby JC, Stocks J, Hooper R, Shaheen SO, Warner JO, Boyle RJ. Prenatal vitamin D supplementation and child respiratory health: a randomised controlled trial. Plos One. 2013;8:E66627.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gore RB, Durrell B, Bishop S, Curbishley L, Woodcock A, Custovic A. High-efficiency vacuum cleaners increase personal mite allergen exposure, but only slightly. Allergy. 2006;61:119–23.

    Article  CAS  PubMed  Google Scholar 

  • Gotzsche PC, Johansen HK. House dust mite control measures for asthma. Cochrane Database Syst Rev. 2008;2:CD001187.

    Google Scholar 

  • Grabenhenrich LB, Gough H, Reich A, Eckers N, Zepp F, Nitsche O, Forster J, Schuster A, Schramm D, Bauer CP, Hoffmann U, Beschorner J, Wagner P, Bergmann R, Bergmann K, Matricardi PM, Wahn U, Lau S, Keil T. Early-life determinants of asthma from birth to age 20 years: a German birth cohort study. J Allergy Clin Immunol. 2014;133:979–88.

    Article  PubMed  Google Scholar 

  • Green R, Simpson A, Custovic A, Faragher B, Chapman M, Woodcock A. The effect of air filtration on airborne dog allergen. Allergy. 1999;54:484–8.

    Article  CAS  PubMed  Google Scholar 

  • Grote M, Valenta R, Reichelt R. Abortive pollen germination: a mechanism of allergen release in birch, alder, and hazel revealed by immunogold electron microscopy. J Allergy Clin Immunol. 2003;111:1017–23.

    Article  PubMed  Google Scholar 

  • Gruzieva O, Bellander T, Eneroth K, Kull I, Melen E, Nordling E, Van Hage M, Wickman M, Moskalenko V, Hulchiy O, Pershagen G. Traffic-related air pollution and development of allergic sensitization in children during the first 8 years of life. J Allergy Clin Immunol. 2012;129:240–6.

    Article  CAS  PubMed  Google Scholar 

  • Guilbert TW, Morgan WJ, Krawiec M, Lemanske RF Jr, Sorkness C, Szefler SJ, Larsen G, Spahn JD, Zeiger RS, Heldt G, Strunk RC, Bacharier LB, Bloomberg GR, Chinchilli VM, Boehmer SJ, Mauger EA, Mauger DT, Taussig LM, Martinez FD, Prevention Of Early Asthma In Kids Study, C. A. R. & Education, N. The prevention of early asthma in kids study: design, rationale and methods for the childhood asthma research and education network. Control Clin Trials. 2004;25:286–310.

    Article  PubMed  Google Scholar 

  • Gunaratne AW, Makrides M, Collins CT. Maternal prenatal and/or postnatal N-3 long chain polyunsaturated fatty acids (LCPUFA) supplementation for preventing allergies in early childhood. Cochrane Database Syst Rev. 2015;7:CD010085.

    Google Scholar 

  • Hansen S, Strom M, Maslova E, Dahl R, Hoffmann HJ, Rytter D, Bech BH, Henriksen TB, Granstrom C, Halldorsson TI, Chavarro JE, Linneberg A, Olsen SF. Fish oil supplementation during pregnancy and allergic respiratory disease in the adult offspring. J Allergy Clin Immunol. 2017;139:104–11. E4

    Article  CAS  PubMed  Google Scholar 

  • Hegarty JM, Rouhbakhsh S, Warner JA, Warner JO. A comparison of the effect of conventional and filter vacuum cleaners on airborne house dust mite allergen. Respir Med. 1995;89:279–84.

    Article  CAS  PubMed  Google Scholar 

  • Hesselmar B, Aberg N, Aberg B, Eriksson B, Bjorksten B. Does early exposure to cat or dog protect against later allergy development? Clin Exp Allergy. 1999;29:611–7.

    Article  CAS  PubMed  Google Scholar 

  • Hodson T, Custovic A, Simpson A, Chapman M, Woodcock A, Green R. Washing the dog reduces dog allergen levels, but the dog needs to be washed twice a week. J Allergy Clin Immunol. 1999;103:581–5.

    Article  CAS  PubMed  Google Scholar 

  • Holowacz S, Blondeau C, Guinobert I, Guilbot A, Hidalgo S, Bisson JF. Lactobacillus salivarius LA307 and Lactobacillus rhamnosus LA305 attenuate skin inflammation in mice. Benef Microbes. 2018;9:299–309.

    Article  CAS  PubMed  Google Scholar 

  • Holt PG, Sly PD. Environmental microbial exposure and protection against asthma. N Engl J Med. 2015;373:2576–8.

    Article  CAS  PubMed  Google Scholar 

  • Horak F Jr, Matthews S, Ihorst G, Arshad SH, Frischer T, Kuehr J, Schwieger A, Forster J, Group, S. S. Effect of mite-impermeable mattress encasings and an educational package on the development of allergies in a multinational randomized, controlled birth-cohort study – 24 months results of the study of prevention of allergy in children in Europe. Clin Exp Allergy. 2004;34:1220–5.

    Article  PubMed  Google Scholar 

  • Horimukai K, Morita K, Narita M, Kondo M, Kitazawa H, Nozaki M, Shigematsu Y, Yoshida K, Niizeki H, Motomura K, Sago H, Takimoto T, Inoue E, Kamemura N, Kido H, Hisatsune J, Sugai M, Murota H, Katayama I, Sasaki T, Amagai M, Morita H, Matsuda A, Matsumoto K, Saito H, Ohya Y. Application of moisturizer to neonates prevents development of atopic dermatitis. J Allergy Clin Immunol. 2014;134:824–30. E6

    Article  PubMed  Google Scholar 

  • Hussain M, Borcard L, Walsh KP, Pena Rodriguez M, Mueller C, Kim BS, Kubo M, Artis D, Noti M. Basophil-derived IL-4 promotes epicutaneous antigen sensitization concomitant with the development of food allergy. J Allergy Clin Immunol. 2018;141:223–34. E5

    Article  CAS  PubMed  Google Scholar 

  • Hypponen E, Sovio U, Wjst M, Patel S, Pekkanen J, Hartikainen AL, Jarvelinb MR. Infant vitamin D supplementation and allergic conditions in adulthood: northern Finland birth cohort 1966. Ann N Y Acad Sci. 2004;1037:84–95.

    Article  CAS  PubMed  Google Scholar 

  • Ichikawa S, Takai T, Yashiki T, Takahashi S, Okumura K, Ogawa H, Kohda D, Hatanaka H. Lipopolysaccharide binding of the mite allergen Der F 2. Genes Cells. 2009;14:1055–65.

    Article  CAS  PubMed  Google Scholar 

  • Iikura Y, Naspitz CK, Mikawa H, Talaricoficho S, Baba M, Sole D, Nishima S. Prevention Of Asthma By Ketotifen In Infants With Atopic Dermatitis. Ann Allergy. 1992;68:233–6.

    CAS  PubMed  Google Scholar 

  • Illi S, Depner M, Genuneit J, Horak E, Loss G, Strunz-Lehner C, Buchele G, Boznanski A, Danielewicz H, Cullinan P, Heederik D, Braun-Fahrlander C, Von Mutius E, Group, G. S. Protection from childhood asthma and allergy in alpine farm environments-the GABRIEL advanced studies. J Allergy Clin Immunol. 2012;129:1470–7. E6

    Article  PubMed  Google Scholar 

  • Jacobsen L, Niggemann B, Dreborg S, Ferdousi HA, Halken S, Host A, Koivikko A, Norberg LA, Valovirta E, Wahn U, Moller C. Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10-year follow-up on the PAT study. Allergy. 2007;62:943–8.

    Article  CAS  PubMed  Google Scholar 

  • Jeong KY, Lee IY, Lee J, Ree HI, Hong CS, Yong TS. Effectiveness of education for control of house dust mites and cockroaches in Seoul, Korea. Korean J Parasitol. 2006;44:73–9.

    Article  PubMed  PubMed Central  Google Scholar 

  • Johansson EK, Bergstrom A, Kull I, Lind T, Soderhall C, Van Hage M, Wickman M, Ballardini N, Wahlgren CF. IgE sensitization in relation to preschool eczema and filaggrin Mutation. J Allergy Clin Immunol. 2017;140:1572–9. E5

    Article  CAS  PubMed  Google Scholar 

  • Johnston JD, Tuttle SC, Nelson MC, Bradshaw RK, Hoybjerg TG, Johnson JB, Kruman BA, Orton TS, Cook RB, Eggett DL, Weber KS. Evaporative cooler use influences temporal indoor relative humidity but not dust mite allergen levels in homes in a semi-arid climate. Plos One. 2016;11:E0147105.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Jones AP, Palmer D, Zhang G, Prescott SL. Cord blood 25-hydroxyvitamin D3 and allergic disease during infancy. Pediatrics. 2012;130:E1128–35.

    Article  PubMed  Google Scholar 

  • Joubert BR, Felix JF, Yousefi P, Bakulski KM, Just AC, Breton C, Reese SE, Markunas CA, Richmond RC, Xu CJ, Kupers LK, Oh SS, Hoyo C, Gruzieva O, Soderhall C, Salas LA, Baiz N, Zhang H, Lepeule J, Ruiz C, Ligthart S, Wang T, Taylor JA, Duijts L, Sharp GC, Jankipersadsing SA, Nilsen RM, Vaez A, Fallin MD, Hu D, Litonjua AA, Fuemmeler BF, Huen K, Kere J, Kull I, Munthe-Kaas MC, Gehring U, Bustamante M, Saurel-Coubizolles MJ, Quraishi BM, Ren J, Tost J, Gonzalez JR, Peters MJ, Haberg SE, Xu Z, Van Meurs JB, Gaunt TR, Kerkhof M, Corpeleijn E, Feinberg AP, Eng C, Baccarelli AA, Benjamin Neelon SE, Bradman A, Merid SK, Bergstrom A, Herceg Z, Hernandez-Vargas H, Brunekreef B, Pinart M, Heude B, Ewart S, Yao J, Lemonnier N, Franco OH, Wu MC, Hofman A, Mcardle W, Van Der Vlies P, Falahi F, Gillman MW, Barcellos LF, Kumar A, Wickman M, Guerra S, Charles MA, Holloway J, Auffray C, Tiemeier HW, Smith GD, Postma D, Hivert MF, Eskenazi B, Vrijheid M, Arshad H, Anto JM, Dehghan A, Karmaus W, Annesi-Maesano I, Sunyer J, Ghantous A, Pershagen G, Holland N, Murphy SK, Demeo DL, Burchard EG, Ladd-Acosta C, Snieder H, Nystad W, Et A. DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis. Am J Hum Genet. 2016;98:680–96.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Katz Y, Rajuan N, Goldberg MR, Eisenberg E, Heyman E, Cohen A, Leshno M. Early exposure to cow’s milk protein is protective against IgE-mediated cow’s milk protein allergy. J Allergy Clin Immunol. 2010;126:77–82. E1

    Article  CAS  PubMed  Google Scholar 

  • Kelleher MM, Dunn-Galvin A, Gray C, Murray DM, Kiely M, Kenny L, Mclean WHI, Irvine AD, Hourihane JO. Skin barrier impairment at birth predicts food allergy at 2 years of age. J Allergy Clin Immunol. 2016;137:1111–6. E8

    Article  CAS  PubMed  Google Scholar 

  • Kercsmar CM, Dearborn DG, Schluchter M, Xue L, Kirchner HL, Sobolewski J, Greenberg SJ, Vesper SJ, Allan T. Reduction in asthma morbidity in children as a result of home remediation aimed at moisture sources. Environ Health Perspect. 2006;114:1574–80.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kespohl S, Raulf M. Mould allergens: where do we stand with molecular allergy diagnostics?: Part 13 of the series molecular allergology. Allergo J Int. 2014;23:120–5.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kidon MI, Chiang WC, Liew WK, Ong TC, Tiong YS, Wong KN, Angus AC, Ong ST, Gao YF, Reginald K, Bi XZ, Shang HS, Chew FT. Mite component-specific IgE repertoire and phenotypes of allergic disease in childhood: the tropical perspective. Pediatr Allergy Immunol. 2011;22:202–10.

    Article  PubMed  Google Scholar 

  • Knox RB. Grass pollen, thunderstorms and asthma. Clin Exp Allergy. 1993;23:354–9.

    Article  CAS  PubMed  Google Scholar 

  • Koplin JJ, Osborne NJ, Wake M, Martin PE, Gurrin LC, Robinson MN, Tey D, Slaa M, Thiele L, Miles L, Anderson D, Tan T, Dang TD, Hill DJ, Lowe AJ, Matheson MC, Ponsonby AL, Tang ML, Dharmage SC, Allen KJ. Can early introduction of egg prevent egg allergy in infants? A population-based study. J Allergy Clin Immunol. 2010;126:807–13.

    Article  PubMed  Google Scholar 

  • Krieger J, Jacobs DE, Ashley PJ, Baeder A, Chew GL, Dearborn D, Hynes HP, Miller JD, Morley R, Rabito F, Zeldin DC. Housing interventions and control of asthma-related indoor biologic agents: a review of the evidence. J Public Health Manag Pract. 2010;16:S11–20.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kull I, Bohme M, Wahlgren CF, Nordvall L, Pershagen G, Wickman M. Breast-feeding reduces the risk for childhood eczema. J Allergy Clin Immunol. 2005;116:657–61.

    Article  PubMed  Google Scholar 

  • Kull I, Melen E, Alm J, Hallberg J, Svartengren M, Van Hage M, Pershagen G, Wickman M, Bergstrom A. Breast-feeding in relation to asthma, lung function, and sensitization in young schoolchildren. J Allergy Clin Immunol. 2010;125:1013–9.

    Article  PubMed  Google Scholar 

  • Lake IR, Jones NR, Agnew M, Goodess CM, Giorgi F, Hamaoui-Laguel L, Semenov MA, Solomon F, Storkey J, Vautard R, Epstein MM. Climate change and future pollen allergy in Europe. Environ Health Perspect. 2017;125:385–91.

    Article  PubMed  Google Scholar 

  • Langan SM, Flohr C, Williams HC. The role of furry pets in eczema: a systematic review. Arch Dermatol. 2007;143:1570–7.

    Article  PubMed  Google Scholar 

  • Lannero E, Wickman M, Van Hage M, Bergstrom A, Pershagen G, Nordvall L. Exposure to environmental tobacco smoke and sensitisation in children. Thorax. 2008;63:172–6.

    Article  CAS  PubMed  Google Scholar 

  • Lee MF, Chen YH, Chiang CH, Lin SJ, Song PP. Analysis of 10 environmental allergen components of the American cockroach in Taiwan. Ann Allergy Asthma Immunol. 2016;117:535–41. E1

    Article  CAS  PubMed  Google Scholar 

  • Leynaert B, Neukirch C, Liard R, Bousquet J, Neukirch F. Quality of life in allergic rhinitis and asthma. A population-based study of young adults. Am J Respir Crit Care Med. 2000;162:1391–6.

    Article  CAS  PubMed  Google Scholar 

  • Lin J, Huang N, Wang H, Fu Q, Wang E, Li P, Yang L, Luo X, Liu X, Liu Z. Identification of a novel cofilin-related molecule (Der F 31) as an allergen from Dermatophagoides farinae. Immunobiology. 2018;223:246–51.

    Article  CAS  PubMed  Google Scholar 

  • Lira AA, De Oliveira MG, De Oliveira LM, Duarte AJ, Sato MN, Victor JR. Maternal immunization with ovalbumin or Dermatophagoides pteronyssinus has opposing effects on fcgammariib expression on offspring B cells. Allergy Asthma Clin Immunol. 2014;10:47.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Litonjua AA, Carey VJ, Laranjo N, Harshfield BJ, Mcelrath TF, O’Connor GT, Sandel M, Iverson RE Jr, Lee-Paritz A, Strunk RC, Bacharier LB, Macones GA, Zeiger RS, Schatz M, Hollis BW, Hornsby E, Hawrylowicz C, Wu AC, Weiss ST. Effect of prenatal supplementation with vitamin D on asthma or recurrent wheezing in offspring by age 3 years: the VDAART randomized clinical trial. JAMA. 2016;315:362–70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lodge CJ, Tan DJ, Lau MX, Dai X, Tham R, Lowe AJ, Bowatte G, Allen KJ, Dharmage SC. Breastfeeding and asthma and allergies: a systematic review and meta-analysis. Acta Paediatr. 2015;104:38–53.

    Article  CAS  PubMed  Google Scholar 

  • Lodrup Carlsen KC, Jaakkola JJ, Nafstad P, Carlsen KH. In utero exposure to cigarette smoking influences lung function at birth. Eur Respir J. 1997;10:1774–9.

    Article  CAS  PubMed  Google Scholar 

  • Lowe AJ, Su JC, Allen KJ, Abramson MJ, Cranswick N, Robertson CF, Forster D, Varigos G, Hamilton S, Kennedy R, Axelrad C, Tang MLK, Dharmage SC. A randomized trial of a barrier lipid replacement strategy for the prevention of atopic dermatitis and allergic sensitization: the PEBBLES pilot study. Br J Dermatol. 2018;178:E19–21.

    Article  CAS  PubMed  Google Scholar 

  • Lynch SV, Wood RA, Boushey H, Bacharier LB, Bloomberg GR, Kattan M, O’connor GT, Sandel MT, Calatroni A, Matsui E, Johnson CC, Lynn H, Visness CM, Jaffee KF, Gergen PJ, Gold DR, Wright RJ, Fujimura K, Rauch M, Busse WW, Gern JE. Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children. J Allergy Clin Immunol. 2014;134:593–601. E12

    Article  PubMed  PubMed Central  Google Scholar 

  • Maas T, Kaper J, Sheikh A, Knottnerus JA, Wesseling G, Dompeling E, Muris JW, Van Schayck CP. Mono and multifaceted inhalant and/or food allergen reduction interventions for preventing asthma in children at high risk of developing asthma. Cochrane Database Syst Rev. 2009;3:CD006480.

    Google Scholar 

  • Majani G, Baiardini I, Giardini A, Senna GE, Minale P, D’ulisse S, Ciprandi G, Canonica GW. Health-related quality of life assessment in young adults with seasonal allergic rhinitis. Allergy. 2001;56:313–7.

    Article  CAS  PubMed  Google Scholar 

  • Mandhane PJ, Sears MR, Poulton R, Greene JM, Lou WY, Taylor DR, Hancox RJ. Cats and dogs and the risk of atopy in childhood and adulthood. J Allergy Clin Immunol. 2009;124:745–50. E4

    Article  PubMed  Google Scholar 

  • Martignon G, Oryszczyn MP, Annesi-Maesano I. Does childhood immunization against infectious diseases protect from the development of atopic disease? Pediatr Allergy Immunol. 2005;16:193–200.

    Article  PubMed  Google Scholar 

  • Martineau AR, Cates CJ, Urashima M, Jensen M, Griffiths AP, Nurmatov U, Sheikh A, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev. 2016;9:CD011511.

    PubMed  Google Scholar 

  • Marx BP, Sloan DM. The effects of trauma history, gender, and race on alcohol use and posttraumatic stress symptoms in a college student sample. Addict Behav. 2003;28:1631–47.

    Article  PubMed  Google Scholar 

  • Masaki K, Fukunaga K, Matsusaka M, Kabata H, Tanosaki T, Mochimaru T, Kamatani T, Ohtsuka K, Baba R, Ueda S, Suzuki Y, Sakamaki F, Oyamada Y, Inoue T, Oguma T, Sayama K, Koh H, Nakamura M, Umeda A, Kamei K, Izuhara K, Asano K, Betsuyaku T. Characteristics of severe asthma with fungal sensitization. Ann Allergy Asthma Immunol. 2017;119:253–7.

    Article  PubMed  Google Scholar 

  • Maslova E, Hansen S, Jensen CB, Thorne-Lyman AL, Strom M, Olsen SF. Vitamin D intake in mid-pregnancy and child allergic disease – a prospective study in 44,825 Danish mother-child pairs. BMC Pregnancy Childbirth. 2013;13:199.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Matheson MC, Erbas B, Balasuriya A, Jenkins MA, Wharton CL, Tang ML, Abramson MJ, Walters EH, Hopper JL, Dharmage SC. Breast-feeding and atopic disease: a cohort study from childhood to middle age. J Allergy Clin Immunol. 2007;120:1051–7.

    Article  PubMed  Google Scholar 

  • Matricardi PM. Allergen-specific immunoprophylaxis: toward secondary prevention of allergic rhinitis? Pediatr Allergy Immunol. 2014;25:15–8.

    Article  PubMed  Google Scholar 

  • Matsui EC, Perzanowski M, Peng RD, Wise RA, Balcer-Whaley S, Newman M, Cunningham A, Divjan A, Bollinger ME, Zhai S, Chew G, Miller RL, Phipatanakul W. Effect of an integrated pest management intervention on asthma symptoms among mouse-sensitized children and adolescents with asthma: a randomized clinical trial. JAMA. 2017;317:1027–36.

    Article  PubMed  PubMed Central  Google Scholar 

  • Mcdonald E, Cook D, Newman T, Griffith L, Cox G, Guyatt G. Effect of air filtration systems on asthma: a systematic review of randomized trials. Chest. 2002;122:1535–42.

    Article  PubMed  Google Scholar 

  • Meltzer EO, Blaiss MS, Derebery MJ, Mahr TA, Gordon BR, Sheth KK, Simmons AL, Wingertzahn MA, Boyle JM. Burden of allergic rhinitis: results from the pediatric allergies in america survey. J Allergy Clin Immunol. 2009;124:S43–70.

    Article  PubMed  Google Scholar 

  • Milner JD, Stein DM, Mccarter R, Moon RY. Early infant multivitamin supplementation is associated with increased risk for food allergy and asthma. Pediatrics. 2004;114:27–32.

    Article  PubMed  Google Scholar 

  • Mimouni Bloch A, Mimouni D, Mimouni M, Gdalevich M. Does breastfeeding protect against allergic rhinitis during childhood? A meta-analysis of prospective studies. Acta Paediatr. 2002;91:275–9.

    Article  CAS  PubMed  Google Scholar 

  • Miyake Y, Miyamoto S, Ohya Y, Sasaki S, Matsunaga I, Yoshida T, Hirota Y, Oda H, Osaka M, Child Health Study G. Association of active and passive smoking with allergic disorders in pregnant Japanese women: baseline data from the Osaka Maternal and Child Health Study. Ann Allergy Asthma Immunol. 2005;94:644–51.

    Article  PubMed  Google Scholar 

  • Moreno A, Pineda F, Alcover J, Rodriguez D, Palacios R, Martinez-Naves E. Orthologous allergens and diagnostic utility of major allergen Alt A 1. Allergy Asthma Immunol Res. 2016;8:428–37.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Moro G, Arslanoglu S, Stahl B, Jelinek J, Wahn U, Boehm G. A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age. Arch Dis Child. 2006;91:814–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Murray CS, Woodcock A, Langley SJ, Morris J, Custovic A, Team IS. Secondary prevention of asthma by the use of inhaled fluticasone propionate in wheezy infants (IFWIN): double-blind, randomised, controlled study. Lancet. 2006;368:754–62.

    Article  CAS  PubMed  Google Scholar 

  • Murray CS, Foden P, Sumner H, Shepley E, Custovic A, Simpson A. Preventing severe asthma exacerbations in children. A randomized trial of mite-impermeable bedcovers. Am J Respir Crit Care Med. 2017;196:150–8.

    Article  CAS  PubMed  Google Scholar 

  • Nasirian H. Infestation of cockroaches (Insecta: Blattaria) in the human dwelling environments: a systematic review and meta-analysis. Acta Trop. 2017;167:86–98.

    Article  PubMed  Google Scholar 

  • Natsume O, Kabashima S, Nakazato J, Yamamoto-Hanada K, Narita M, Kondo M, Saito M, Kishino A, Takimoto T, Inoue E, Tang J, Kido H, Wong GW, Matsumoto K, Saito H, Ohya Y, Team PS. Two-step egg introduction for prevention of egg allergy in high-risk infants with eczema (PETIT): a randomised, double-blind, placebo-controlled trial. Lancet. 2017;389:276–86.

    Article  PubMed  Google Scholar 

  • Neeland MR, Koplin JJ, Dang TD, Dharmage SC, Tang ML, Prescott SL, Saffery R, Martino DJ, Allen KJ. Early life innate immune signatures of persistent food allergy. J Allergy Clin Immunol. 2018;142(3):857–64.

    Article  PubMed  CAS  Google Scholar 

  • Netting MJ, Campbell DE, Koplin JJ, Beck KM, Mcwilliam V, Dharmage SC, Tang MLK, Ponsonby AL, Prescott SL, Vale S, Loh RKS, Makrides M, Allen KJ, Centre For, F., Allergy Research, T. A. S. O. C. I., Allergy, T. N. A. S. & The Australian Infant Feeding Summit Consensus, G. An Australian consensus on infant feeding guidelines to prevent food allergy: outcomes from the Australian Infant Feeding Summit. J Allergy Clin Immunol Pract. 2017;5:1617–24.

    Article  PubMed  Google Scholar 

  • Nicholas CE, Wegienka GR, Havstad SL, Zoratti EM, Ownby DR, Johnson CC. Dog allergen levels in homes with hypoallergenic compared with nonhypoallergenic dogs. Am J Rhinol Allergy. 2011;25:252–6.

    Article  PubMed  PubMed Central  Google Scholar 

  • Nwaru BI, Takkinen HM, Niemela O, Kaila M, Erkkola M, Ahonen S, Haapala AM, Kenward MG, Pekkanen J, Lahesmaa R, Kere J, Simell O, Veijola R, Ilonen J, Hyoty H, Knip M, Virtanen SM. Timing of infant feeding in relation to childhood asthma and allergic diseases. J Allergy Clin Immunol. 2013;131:78–86.

    Article  PubMed  Google Scholar 

  • O’Connor GT, Lynch SV, Bloomberg GR, Kattan M, Wood RA, Gergen PJ, Jaffee KF, Calatroni A, Bacharier LB, Beigelman A, Sandel MT, Johnson CC, Faruqi A, Santee C, Fujimura KE, Fadrosh D, Boushey H, Visness CM, Gern JE. Early-life home environment and risk of asthma among inner-city children. J Allergy Clin Immunol. 2018;141(4):1468–75.

    Article  PubMed  Google Scholar 

  • Oddy WH. Breastfeeding and asthma in children: findings from a West Australian study. Breastfeed Rev. 2000;8:5–11.

    CAS  PubMed  Google Scholar 

  • Olesen AB, Juul S, Thestrup-Pedersen K. Atopic dermatitis is increased following vaccination for measles, mumps and rubella or measles infection. Acta Derm Venereol. 2003;83:445–50.

    Article  PubMed  Google Scholar 

  • Ong KH, Lewis RD, Dixit A, Macdonald M, Yang M, Qian Z. Inactivation of dust mites, dust mite allergen, and mold from carpet. J Occup Environ Hyg. 2014;11:519–27.

    Article  CAS  PubMed  Google Scholar 

  • Onizawa Y, Noguchi E, Okada M, Sumazaki R, Hayashi D. The association of the delayed introduction of cow’s milk with IgE-mediated cow’s milk allergies. J Allergy Clin Immunol Pract. 2016;4:481–8. E2

    Article  PubMed  Google Scholar 

  • Oribe Y, Miyazaki Y. Effects of relative humidity on the population growth of house-dust mites. J Physiol Anthropol Appl Human Sci. 2000;19:201–3.

    Article  CAS  PubMed  Google Scholar 

  • Osborn DA, Sinn J. Soy formula for prevention of allergy and food intolerance in infants. Cochrane Database Syst Rev. 2006;4:CD003741.

    Google Scholar 

  • Osborn DA, Sinn JK. Probiotics in infants for prevention of allergic disease and food hypersensitivity. Cochrane Database Syst Rev. 2007;4:CD006475.

    Google Scholar 

  • Ouwehand AC, Isolauri E, He F, Hashimoto H, Benno Y, Salminen S. Differences in Bifidobacterium flora composition in allergic and healthy infants. J Allergy Clin Immunol. 2001;108:144–5.

    Article  CAS  PubMed  Google Scholar 

  • Ownby DR, Johnson CC, Peterson EL. Exposure to dogs and cats in the first year of life and risk of allergic sensitization at 6 to 7 years of age. JAMA. 2002;288:963–72.

    Article  PubMed  Google Scholar 

  • Pajno GB, Barberio G, De Luca F, Morabito L, Parmiani S. Prevention of new sensitizations in asthmatic children monosensitized to house dust mite by specific immunotherapy. A six-year follow-up study. Clin Exp Allergy. 2001;31:1392–7.

    Article  CAS  PubMed  Google Scholar 

  • Palmer DJ, Sullivan TR, Gold MS, Prescott SL, Makrides M. Randomized controlled trial of early regular egg intake to prevent egg allergy. J Allergy Clin Immunol. 2017;139:1600–7. E2

    Article  CAS  PubMed  Google Scholar 

  • Patchett K, Lewis S, Crane J, Fitzharris P. Cat allergen (Fel D 1) levels on school children’s clothing and in primary school classrooms in Wellington, New Zealand. J Allergy Clin Immunol. 1997;100:755–9.

    Article  CAS  PubMed  Google Scholar 

  • Perkin MR, Logan K, Marrs T, Radulovic S, Craven J, Flohr C, Lack G, Team EATS. Enquiring about tolerance (EAT) study: feasibility of an early allergenic food introduction regimen. J Allergy Clin Immunol. 2016a;137:1477–86. E8

    Article  PubMed  PubMed Central  Google Scholar 

  • Perkin MR, Logan K, Tseng A, Raji B, Ayis S, Peacock J, Brough H, Marrs T, Radulovic S, Craven J, Flohr C, Lack G, Team, E. A. T. S. Randomized trial of introduction of allergenic foods in breast-fed infants. N Engl J Med. 2016b;374:1733–43.

    Article  CAS  PubMed  Google Scholar 

  • Peroni DG, Ress M, Pigozzi R, Del Giudice MM, Bodini A, Piacentini GL. Efficacy in allergen control and air permeability of different materials used for bed encasement. Allergy. 2004;59:969–72.

    Article  CAS  PubMed  Google Scholar 

  • Perzanowski MS, Ronmark E, Platts-Mills TA, Lundback B. Effect of cat and dog ownership on sensitization and development of asthma among preteenage children. Am J Respir Crit Care Med. 2002;166:696–702.

    Article  PubMed  Google Scholar 

  • Pesonen M, Kallio MJ, Ranki A, Siimes MA. Prolonged exclusive breastfeeding is associated with increased atopic dermatitis: a prospective follow-up study of unselected healthy newborns from birth to age 20 years. Clin Exp Allergy. 2006;36:1011–8.

    Article  CAS  PubMed  Google Scholar 

  • Peters JL, Suglia SF, Platts-Mills TA, Hosen J, Gold DR, Wright RJ. Relationships among prenatal aeroallergen exposure and maternal and cord blood IgE: project access. J Allergy Clin Immunol. 2009;123:1041–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Phipatanakul W, Eggleston PA, Wright EC, Wood RA, National Coooperative Inner-City Asthma, S. Mouse allergen. II. The relationship of mouse allergen exposure to mouse sensitization and asthma morbidity in inner-city children with asthma. J Allergy Clin Immunol. 2000;106:1075–80.

    Article  CAS  PubMed  Google Scholar 

  • Pineiro-Hermida S, Alfaro-Arnedo E, Gregory JA, Torrens R, Ruiz-Martinez C, Adner M, Lopez IP, Pichel JG. Characterization of the acute inflammatory profile and resolution of airway inflammation after Igf1r-gene targeting in a murine model of HDM-induced asthma. Plos One. 2017;12:E0190159.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Platts-Mills TA. Allergen avoidance in the treatment of asthma: problems with the meta-analyses. J Allergy Clin Immunol. 2008;122:694–6.

    Article  PubMed  Google Scholar 

  • Platts-Mills TA, Sporik RB, Wheatley LM, Heymann PW. Is there a dose-response relationship between exposure to indoor allergens and symptoms of asthma? J Allergy Clin Immunol. 1995;96:435–40.

    Article  CAS  PubMed  Google Scholar 

  • Pongracic JA, Visness CM, Gruchalla RS, Evans R 3rd, Mitchell HE. Effect of mouse allergen and rodent environmental intervention on asthma in inner-city children. Ann Allergy Asthma Immunol. 2008;101:35–41.

    Article  PubMed  Google Scholar 

  • Popplewell EJ, Innes VA, Lloyd-Hughes S, Jenkins EL, Khdir K, Bryant TN, Warner JO, Warner JA. The effect of high-efficiency and standard vacuum-cleaners on mite, cat and dog allergen levels and clinical progress. Pediatr Allergy Immunol. 2000;11:142–8.

    Article  CAS  PubMed  Google Scholar 

  • Portnoy J, Kennedy K, Sublett J, Phipatanakul W, Matsui E, Barnes C, Grimes C, Miller JD, Seltzer JM, Williams PB, Bernstein JA, Bernstein DI, Blessing-Moore J, Cox L, Khan DA, Lang DM, Nicklas RA, Oppenheimer J. Environmental assessment and exposure control: a practice parameter – furry animals. Ann Allergy Asthma Immunol. 2012;108(223):E1–15.

    Google Scholar 

  • Portnoy J, Chew GL, Phipatanakul W, Williams PB, Grimes C, Kennedy K, Matsui EC, Miller JD, Bernstein D, Blessing-Moore J, Cox L, Khan D, Lang D, Nicklas R, Oppenheimer J, Randolph C, Schuller D, Spector S, Tilles SA, Wallace D, Seltzer J, Sublett J, Joint Task Force On Practice, P. Environmental assessment and exposure reduction of cockroaches: a practice parameter. J Allergy Clin Immunol. 2013;132:802–8. E1-25

    Article  PubMed  Google Scholar 

  • Purvis DJ, Thompson JM, Clark PM, Robinson E, Black PN, Wild CJ, Mitchell EA. Risk factors for atopic dermatitis in New Zealand children at 3.5 years of age. Br J Dermatol. 2005;152:742–9.

    Article  CAS  PubMed  Google Scholar 

  • Qiu S, Fan X, Yang Y, Dong P, Zhou W, Xu Y, Zhou Y, Guo F, Zheng Y, Yang JQ. Schistosoma japonicum infection downregulates house dust mite-induced allergic airway inflammation in mice. Plos One. 2017;12:E0179565.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Rabito FA, Carlson JC, He H, Werthmann D, Schal C. A single intervention for cockroach control reduces cockroach exposure and asthma morbidity in children. J Allergy Clin Immunol. 2017;140:565–70.

    Article  PubMed  Google Scholar 

  • Ray NF, Baraniuk JN, Thamer M, Rinehart CS, Gergen PJ, Kaliner M, Josephs S, Pung YH. Direct expenditures for the treatment of allergic rhinoconjunctivitis in 1996, including the contributions of related airway illnesses. J Allergy Clin Immunol. 1999;103:401–7.

    Article  CAS  PubMed  Google Scholar 

  • Rebmann H, Weber AK, Focke I, Rusche A, Lau S, Ehnert B, Wahn U. Does benzyl benzoate prevent colonization of new mattresses by mites? A prospective study. Allergy. 1996;51:876–82.

    CAS  PubMed  Google Scholar 

  • Reininger R, Varga EM, Zach M, Balic N, Lindemeier AD, Swoboda I, Gronlund H, Van Hage M, Rumpold H, Valenta R, Spitzauer S. Detection of an allergen in dog dander that cross-reacts with the major cat allergen, Fel D 1. Clin Exp Allergy. 2007;37:116–24.

    Article  CAS  PubMed  Google Scholar 

  • Richgels PK, Yamani A, Chougnet CA, Lewkowich IP. Maternal house dust mite exposure during pregnancy enhances severity of house dust mite-induced asthma in murine offspring. J Allergy Clin Immunol. 2017;140:1404–15. E9

    Article  PubMed  PubMed Central  Google Scholar 

  • Roduit C, Frei R, Depner M, Schaub B, Loss G, Genuneit J, Pfefferle P, Hyvarinen A, Karvonen AM, Riedler J, Dalphin JC, Pekkanen J, Von Mutius E, Braun-Fahrlander C, Lauener R, Group, P. S. Increased food diversity in the first year of life is inversely associated with allergic diseases. J Allergy Clin Immunol. 2014;133:1056–64.

    Article  PubMed  Google Scholar 

  • Rosenstreich DL, Eggleston P, Kattan M, Baker D, Slavin RG, Gergen P, Mitchell H, Mcniff-Mortimer K, Lynn H, Ownby D, Malveaux F. The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma. N Engl J Med. 1997;336:1356–63.

    Article  CAS  PubMed  Google Scholar 

  • Ross MP, Ferguson M, Street D, Klontz K, Schroeder T, Luccioli S. Analysis of food-allergic and anaphylactic events in the national electronic injury surveillance system. J Allergy Clin Immunol. 2008;121:166–71.

    Article  PubMed  Google Scholar 

  • Saarinen UM, Kajosaari M. Breastfeeding as prophylaxis against atopic disease: prospective follow-up study until 17 years old. Lancet. 1995;346:1065–9.

    Article  CAS  PubMed  Google Scholar 

  • Salo PM, Calatroni A, Gergen PJ, Hoppin JA, Sever ML, Jaramillo R, Arbes SJ Jr, Zeldin DC. Allergy-related outcomes in relation to serum IgE: results from the National Health and Nutrition Examination Survey 2005-2006. J Allergy Clin Immunol. 2011;127:1226–35. E7

    Article  PubMed  PubMed Central  Google Scholar 

  • Salo PM, Wilkerson J, Rose KM, Cohn RD, Calatroni A, Mitchell HE, Sever ML, Gergen PJ, Thorne PS, Zeldin DC. Bedroom allergen exposures in us households. J Allergy Clin Immunol. 2018;141(5):1870–79.

    Article  PubMed  CAS  Google Scholar 

  • Sampson HA, Aceves S, Bock SA, James J, Jones S, Lang D, Nadeau K, Nowak-Wegrzyn A, Oppenheimer J, Perry TT, Randolph C, Sicherer SH, Simon RA, Vickery BP, Wood R, Joint Task Force On Practice P, Bernstein D, Blessing-Moore J, Khan D, Lang D, Nicklas R, Oppenheimer J, Portnoy J, Randolph C, Schuller D, Spector S, Tilles SA, Wallace D, Practice Parameter W, Sampson HA, Aceves S, Bock SA, James J, Jones S, Lang D, Nadeau K, Nowak-Wegrzyn A, Oppenheimer J, Perry TT, Randolph C, Sicherer SH, Simon RA, Vickery BP, Wood R. Food allergy: a practice parameter update-2014. J Allergy Clin Immunol. 2014;134:1016–25. E43

    Article  PubMed  Google Scholar 

  • Sauni R, Verbeek JH, Uitti J, Jauhiainen M, Kreiss K, Sigsgaard T. Remediating buildings damaged by dampness and mould for preventing or reducing respiratory tract symptoms, infections and asthma. Cochrane Database Syst Rev. 2015;2:CD007897.

    Google Scholar 

  • Savage J, Sicherer S, Wood R. The natural history of food allergy. J Allergy Clin Immunol Pract. 2016;4:196–203. Quiz 204

    Article  PubMed  Google Scholar 

  • Sbihi H, Allen RW, Becker A, Brook JR, Mandhane P, Scott JA, Sears MR, Subbarao P, Takaro TK, Turvey SE, Brauer M. Perinatal exposure to traffic-related air pollution and atopy at 1 year of age in a multi-center Canadian birth cohort study. Environ Health Perspect. 2015;123:902–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schindler T, Sinn JK, Osborn DA. Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy. Cochrane Database Syst Rev. 2016;10:CD010112.

    PubMed  Google Scholar 

  • Schram-Bijkerk D, Doekes G, Boeve M, Douwes J, Riedler J, Ublagger E, Von Mutius E, Budde J, Pershagen G, Van Hage M, Wickman M, Braun-Fahrlander C, Waser M, Brunekreef B, Group, P. S. Nonlinear relations between house dust mite allergen levels and mite sensitization in farm and nonfarm children. Allergy. 2006;61:640–7.

    Article  CAS  PubMed  Google Scholar 

  • Sears MR, Greene JM, Willan AR, Taylor DR, Flannery EM, Cowan JO, Herbison GP, Poulton R. Long-term relation between breastfeeding and development of atopy and asthma in children and young adults: a longitudinal study. Lancet. 2002;360:901–7.

    Article  PubMed  Google Scholar 

  • Sedaghat AR, Matsui EC, Baxi SN, Bollinger ME, Miller R, Perzanowski M, Phipatanakul W. Mouse sensitivity is an independent risk factor for rhinitis in children with asthma. J Allergy Clin Immunol Pract. 2016;4:82–8. E1

    Article  PubMed  Google Scholar 

  • Settipane RA. Demographics and epidemiology of allergic and nonallergic rhinitis. Allergy Asthma Proc. 2001;22:185–9.

    CAS  PubMed  Google Scholar 

  • Sever ML, Arbes SJ Jr, Gore JC, Santangelo RG, Vaughn B, Mitchell H, Schal C, Zeldin DC. Cockroach allergen reduction by cockroach control alone in low-income urban homes: a randomized control trial. J Allergy Clin Immunol. 2007;120:849–55.

    Article  PubMed  PubMed Central  Google Scholar 

  • Shakib F, Schulz O, Sewell H. A mite subversive: cleavage of CD23 and CD25 by Der P 1 enhances allergenicity. Immunol Today. 1998;19:313–6.

    Article  CAS  PubMed  Google Scholar 

  • Sheikh A, Hurwitz B, Shehata Y. House dust mite avoidance measures for perennial allergic rhinitis. Cochrane Database Syst Rev. 2007;1:CD001563.

    Google Scholar 

  • Sheikh A, Hurwitz B, Nurmatov U, Van Schayck CP. House dust mite avoidance measures for perennial allergic rhinitis. Cochrane Database Syst Rev. 2010;7:CD001563.

    Google Scholar 

  • Shirai T, Matsui T, Suzuki K, Chida K. Effect of pet removal on pet allergic asthma. Chest. 2005;127:1565–71.

    Article  PubMed  Google Scholar 

  • Silvers KM, Frampton CM, Wickens K, Pattemore PK, Ingham T, Fishwick D, Crane J, Town GI, Epton MJ, New Zealand, A. & Allergy Cohort Study, G. Breastfeeding protects against current asthma up to 6 years of age. J Pediatr. 2012;160:991–6. E1

    Article  PubMed  Google Scholar 

  • Simpson EL, Chalmers JR, Hanifin JM, Thomas KS, Cork MJ, Mclean WH, Brown SJ, Chen Z, Chen Y, Williams HC. Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention. J Allergy Clin Immunol. 2014;134:818–23.

    Article  PubMed  PubMed Central  Google Scholar 

  • Singh K, Axelrod S, Bielory L. The epidemiology of ocular and nasal allergy in the United States, 1988–1994. J Allergy Clin Immunol. 2010;126:778–83. E6

    Article  PubMed  Google Scholar 

  • Small BM. Creating mold-free buildings: a key to avoiding health effects of indoor molds. Arch Environ Health. 2003;58:523–7.

    Article  PubMed  Google Scholar 

  • Stillerman A, Nachtsheim C, Li W, Albrecht M, Waldman J. Efficacy of a novel air filtration pillow for avoidance of perennial allergens in symptomatic adults. Ann Allergy Asthma Immunol. 2010;104:440–9.

    Article  PubMed  Google Scholar 

  • Sulser C, Schulz G, Wagner P, Sommerfeld C, Keil T, Reich A, Wahn U, Lau S. Can the use of HEPA cleaners in homes of asthmatic children and adolescents sensitized to cat and dog allergens decrease bronchial hyperresponsiveness and allergen contents in solid dust? Int Arch Allergy Immunol. 2009;148:23–30.

    Article  CAS  PubMed  Google Scholar 

  • Tanaka A, Fujiwara A, Uchida Y, Yamaguchi M, Ohta S, Homma T, Watanabe Y, Yamamoto M, Suzuki S, Yokoe T, Sagara H. Evaluation of the association between sensitization to common inhalant fungi and poor asthma control. Ann Allergy Asthma Immunol. 2016;117:163–8. E1

    Article  PubMed  Google Scholar 

  • Thygarajan A, Burks AW. American Academy of Pediatrics recommendations on the effects of early nutritional interventions on the development of atopic disease. Curr Opin Pediatr. 2008;20:698–702.

    Article  PubMed  PubMed Central  Google Scholar 

  • Togias A, Cooper SF, Acebal ML, Assa’ad A, Baker JR Jr, Beck LA, Block J, Byrd-Bredbenner C, Chan ES, Eichenfield LF, Fleischer DM, Fuchs GJ 3rd, Furuta GT, Greenhawt MJ, Gupta RS, Habich M, Jones SM, Keaton K, Muraro A, Plaut M, Rosenwasser LJ, Rotrosen D, Sampson HA, Schneider LC, Sicherer SH, Sidbury R, Spergel J, Stukus DR, Venter C, Boyce JA. Addendum guidelines for the prevention of peanut allergy in the United States: report of the National Institute of Allergy and Infectious Diseases-Sponsored Expert Panel. J Allergy Clin Immunol. 2017;139:29–44.

    Article  PubMed  PubMed Central  Google Scholar 

  • Tran MM, Lefebvre DL, Dharma C, Dai D, Lou WYW, Subbarao P, Becker AB, Mandhane PJ, Turvey SE, Sears MR, Canadian Healthy Infant Longitudinal Development Study, I. Predicting the atopic march: results from the canadian healthy infant longitudinal development study. J Allergy Clin Immunol. 2018;141:601–7. E8

    Article  PubMed  Google Scholar 

  • Tsurikisawa N, Saito A, Oshikata C, Yasueda H, Akiyama K. Effective allergen avoidance for reducing exposure to house dust mite allergens and improving disease management in adult atopic asthmatics. J Asthma. 2016;53:843–53.

    Article  CAS  PubMed  Google Scholar 

  • Turturice BA, Ranjan R, Nguyen B, Hughes LM, Andropolis KE, Gold DR, Litonjua AA, Oken E, Perkins DL, Finn PW. Perinatal bacterial exposure contributes to IL-13 aeroallergen response. Am J Respir Cell Mol Biol. 2017;57:419–27.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Valovirta E, Petersen TH, Piotrowska T, Laursen MK, Andersen JS, Sorensen HF, Klink R, Investigators GAP. Results from the 5-year SQ grass sublingual immunotherapy tablet asthma prevention (GAP) trial in children with grass pollen allergy. J Allergy Clin Immunol. 2018;141:529–38. E13

    Article  CAS  PubMed  Google Scholar 

  • Van Boven FE. Effectiveness of mite-impermeable covers: a hypothesis-generating meta-analysis. Clin Exp Allergy. 2014;44:1473–83.

    Article  PubMed  Google Scholar 

  • Van Schayck OC, Maas T, Kaper J, Knottnerus AJ, Sheikh A. Is there any role for allergen avoidance in the primary prevention of childhood asthma? J Allergy Clin Immunol. 2007;119:1323–8.

    Article  PubMed  CAS  Google Scholar 

  • Vaughan JW, Woodfolk JA, Platts-Mills TA. Assessment of vacuum cleaners and vacuum cleaner bags recommended for allergic subjects. J Allergy Clin Immunol. 1999;104:1079–83.

    Article  CAS  PubMed  Google Scholar 

  • Vervloet D, Charpin D, Haddi E, N’guyen A, Birnbaum J, Soler M, Van Der Brempt X. Medication requirements and house dust mite exposure in mite-sensitive asthmatics. Allergy. 1991;46:554–8.

    Article  CAS  PubMed  Google Scholar 

  • Von Berg A, Filipiak-Pittroff B, Kramer U, Hoffmann B, Link E, Beckmann C, Hoffmann U, Reinhardt D, Grubl A, Heinrich J, Wichmann HE, Bauer CP, Koletzko S, Berdel D, Group, G. I. S. Allergies in high-risk schoolchildren after early intervention with cow’s milk protein hydrolysates: 10-year results from the German Infant Nutritional Intervention (GINI) study. J Allergy Clin Immunol. 2013;131:1565–73.

    Article  CAS  Google Scholar 

  • Von Berg A, Filipiak-Pittroff B, Schulz H, Hoffmann U, Link E, Sussmann M, Schnappinger M, Bruske I, Standl M, Kramer U, Hoffmann B, Heinrich J, Bauer CP, Koletzko S, Berdel D, Group, G. I. S. Allergic manifestation 15 years after early intervention with hydrolyzed formulas – the GINI Study. Allergy. 2016;71:210–9.

    Article  CAS  Google Scholar 

  • Vredegoor DW, Willemse T, Chapman MD, Heederik DJ, Krop EJ. Can F 1 levels in hair and homes of different dog breeds: lack of evidence to describe any dog breed as hypoallergenic. J Allergy Clin Immunol. 2012;130:904–9. E7

    Article  CAS  PubMed  Google Scholar 

  • Wahn U. Allergic factors associated with the development of asthma and the influence of cetirizine in a double-blind, randomised, placebo-controlled trial: first results of ETAC. Early treatment of the atopic child. Pediatr Allergy Immunol. 1998;9:116–24.

    Article  Google Scholar 

  • Wan H, Winton HL, Soeller C, Tovey ER, Gruenert DC, Thompson PJ, Stewart GA, Taylor GW, Garrod DR, Cannell MB, Robinson C. Der P 1 facilitates transepithelial allergen delivery by disruption of tight junctions. J Clin Invest. 1999;104:123–33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang JY. The innate immune response in house dust mite-induced allergic inflammation. Allergy Asthma Immunol Res. 2013;5:68–74.

    Article  CAS  PubMed  Google Scholar 

  • Wang C, Bennett GW. Comparative study of integrated pest management and baiting for german cockroach management in public housing. J Econ Entomol. 2006;99:879–85.

    Article  CAS  PubMed  Google Scholar 

  • Wang H, Lin J, Zeng L, Ouyang C, Ran P, Yang P, Liu Z. Der F 31, a novel allergen from Dermatophagoides Farinae, activates epithelial cells and enhances lung-resident group 2 innate lymphoid cells. Sci Rep. 2017;7:8519.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • WAO. World Allergy Organization white book on allergy [online]. Milwaukee: World Allergy Association; 2011. Available: http://www.worldallergy.org/userfiles/file/wao-white-book-on-allergy_web.pdf. Accessed 25 Feb 2018.

  • Warner JO, Child, E. S. G. E. T. O. T. A. A double-blinded, randomized, placebo-controlled trial of cetirizine in preventing the onset of asthma in children with atopic dermatitis: 18 months’ treatment and 18 months’ posttreatment follow-up. J Allergy Clin Immunol. 2001;108:929–37.

    Article  CAS  PubMed  Google Scholar 

  • Weghofer M, Grote M, Resch Y, Casset A, Kneidinger M, Kopec J, Thomas WR, Fernandez-Caldas E, Kabesch M, Ferrara R, Mari A, Purohit A, Pauli G, Horak F, Keller W, Valent P, Valenta R, Vrtala S. Identification of Der P 23, a peritrophin-like protein, as a new major Dermatophagoides pteronyssinus allergen associated with the peritrophic matrix of mite fecal pellets. J Immunol. 2013;190:3059–67.

    Article  CAS  PubMed  Google Scholar 

  • Wei-Liang Tan J, Valerio C, Barnes EH, Turner PJ, Van Asperen PA, Kakakios AM, Campbell DE, Beating Egg Allergy Trial Study, G. A randomized trial of egg introduction from 4 months of age in infants at risk for egg allergy. J Allergy Clin Immunol. 2017;139:1621–8. E8

    Article  PubMed  Google Scholar 

  • WHO. Global surveillance, prevention and control of chronic respiratory diseases a comprehensive approach [online]. World Health Organization; 2007. Available: http://apps.who.int/iris/bitstream/10665/43776/1/9789241563468_eng.pdf

  • Winn AK, Salo PM, Klein C, Sever ML, Harris SF, Johndrow D, Crockett PW, Cohn RD, Zeldin DC. Efficacy of an in-home test kit in reducing dust mite allergen levels: results of a randomized controlled pilot study. J Asthma. 2016;53:133–8.

    Article  CAS  PubMed  Google Scholar 

  • Wjst M. Another explanation for the low allergy rate in the rural alpine foothills. Clin Mol Allergy. 2005;3:7.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wood RA. Laboratory animal allergens. Ilar J. 2001;42:12–6.

    Article  CAS  PubMed  Google Scholar 

  • Wood RA, Chapman MD, Adkinson NF Jr, Eggleston PA. The effect of cat removal on allergen content in household-dust samples. J Allergy Clin Immunol. 1989;83:730–4.

    Article  CAS  PubMed  Google Scholar 

  • Wood RA, Johnson EF, Van Natta ML, Chen PH, Eggleston PA. A placebo-controlled trial of a HEPA air cleaner in the treatment of cat allergy. Am J Respir Crit Care Med. 1998;158:115–20.

    Article  CAS  PubMed  Google Scholar 

  • Woodcock A, Forster L, Matthews E, Martin J, Letley L, Vickers M, Britton J, Strachan D, Howarth P, Altmann D, Frost C, Custovic A, Medical Research Council General Practice Research, F. Control of exposure to mite allergen and allergen-impermeable bed covers for adults with asthma. N Engl J Med. 2003;349:225–36.

    Article  PubMed  Google Scholar 

  • Woodfolk JA, Luczynska CM, De Blay F, Chapman MD, Platts-Mills TA. The effect of vacuum cleaners on the concentration and particle size distribution of airborne cat allergen. J Allergy Clin Immunol. 1993;91:829–37.

    Article  CAS  PubMed  Google Scholar 

  • Woodfolk JA, Hayden ML, Couture N, Platts-Mills TA. Chemical treatment of carpets to reduce allergen: comparison of the effects of tannic acid and other treatments on proteins derived from dust mites and cats. J Allergy Clin Immunol. 1995;96:325–33.

    Article  CAS  PubMed  Google Scholar 

  • Xepapadaki P, Manios Y, Liarigkovinos T, Grammatikaki E, Douladiris N, Kortsalioudaki C, Papadopoulos NG. Association of passive exposure of pregnant women to environmental tobacco smoke with asthma symptoms in children. Pediatr Allergy Immunol. 2009;20:423–9.

    Article  PubMed  Google Scholar 

  • Yepes-Nunez JJ, Brozek JL, Fiocchi A, Pawankar R, Cuello-Garcia C, Zhang Y, Morgano GP, Agarwal A, Gandhi S, Terracciano L, Schunemann HJ. Vitamin D supplementation in primary allergy prevention: systematic review of randomized and non-randomized studies. Allergy. 2018;73:37–49.

    Article  CAS  PubMed  Google Scholar 

  • Yin SC, Liao EC, Ye CX, Chang CY, Tsai JJ. Effect of mite allergenic components on innate immune response: synergy of protease (Group 1 & 3) and non-protease (Group 2 & 7) allergens. Immunobiology. 2018;223(6-7):443–48.

    Article  CAS  PubMed  Google Scholar 

  • Zha C, Wang C, Buckley B, Yang I, Wang D, Eiden AL, Cooper R. Pest prevalence and evaluation of community-wide integrated pest management for reducing cockroach infestations and indoor insecticide residues. J Econ Entomol. 2018;111(2):795–802.

    Article  PubMed  Google Scholar 

  • Zhang YC, Perzanowski MS, Chew GL. Sub-lethal exposure of cockroaches to boric acid pesticide contributes to increased Bla G 2 excretion. Allergy. 2005;60:965–8.

    Article  CAS  PubMed  Google Scholar 

  • Zhang X, Zhong W, Meng Q, Lin Q, Fang C, Huang X, Li C, Huang Y, Tan J. Ambient PM2.5 exposure exacerbates severity of allergic asthma in previously sensitized mice. J Asthma. 2015;52:785–94.

    Article  PubMed  Google Scholar 

  • Zhang Z, Biagini Myers JM, Brandt EB, Ryan PH, Lindsey M, Mintz-Cole RA, Reponen T, Vesper SJ, Forde F, Ruff B, Bass SA, Lemasters GK, Bernstein DI, Lockey J, Budelsky AL, Khurana Hershey GK. Beta-glucan exacerbates allergic asthma independent of fungal sensitization and promotes steroid-resistant Th2/Th17 responses. J Allergy Clin Immunol. 2017;139:54–65. E8

    Article  CAS  PubMed  Google Scholar 

  • Zhu J, Dhammi A, Van Kretschmar JB, Vargo EL, Apperson CS, Michael Roe R. Novel use of aliphatic n-methyl ketones as a fumigant and alternative to methyl bromide for insect control. Pest Manag Sci. 2018;74:648–57.

    Article  CAS  PubMed  Google Scholar 

  • Zirngibl A, Franke K, Gehring U, Von Berg A, Berdel D, Bauer CP, Reinhardt D, Wichmann HE, Heinrich J, Group, G. S. Exposure to pets and atopic dermatitis during the first two years of life. a cohort study. Pediatr Allergy Immunol. 2002;13:394–401.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sylvette Nazario .

Editor information

Editors and Affiliations

Section Editor information

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Cosme-Blanco, W., Arce-Ayala, Y., Malinow, I., Nazario, S. (2018). Primary and Secondary Environmental Control Measures for Allergic Diseases. In: Craig, T., Ledford, D. (eds) Allergy and Asthma. Springer, Cham. https://doi.org/10.1007/978-3-319-58726-4_36-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-58726-4_36-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-58726-4

  • Online ISBN: 978-3-319-58726-4

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics